Geriatric Pharmacology and Pharmacotherapy
The number of individuals aged 65 and over continues to significantly rise compared to the general population all over the world. The burden of chronic diseases increasing with age and the consequent polypharmacy constitute an important public health problem. Diseases especially affecting the cardiovascular, respiratory, central nervous, endocrine, gastrointestinal, urinary, and musculoskeletal systems and the eye are frequently encountered, as is the increasing prevalence of cancer. On the other hand, the impact of the aging organism on all of the systems in the body could alter pathophysiological processes and substantially modify the response to medications. Such differences are expected to be considered by physicians when managing pharmacotherapy in a geriatric patient.
This book titled ”Geriatric Pharmacology and Pharmacotherapy” by Türkiye Klinikleri has been prepared in two parts. The first part focuses on how the aging organism can modify drug responses (pharmacokinetic and pharmacodynamic changes) and the principles of rational drug use, drug management, prescribing cascade, adverse drug reactions, potential risks of herbal products, therapeutic drug monitoring, as well as inappropriate drug use guidelines in the elderly population. In addition, several chapters are included for scholars who are interested in geriatric research: experimental animal models, pharmacoepidemiologic and clinical drug trials, and novel drugs for the elderly. The second part of the book consists of chapters that cover organ- or system-based geriatric pharmacotherapy, considering the critical aspects of the most prevalent conditions and their medications in the elderly in light of current literature. We believe that each chapter of the book provides pharmacologists, physicians, and healthcare professionals with concise ”pill” knowledge, and we hope that it will be a useful and up-to-date resource for drug use in the elderly.
Prof. Dr. Canan ULUOĞLU
Editor
Gazi University Faculty of Medicine, Department of Medical Pharmacology, Ankara, Türkiye
Prof. Dr. Aylin ARICI
Associate Editor
Dokuz Eylül University Faculty of Medicine, Department of Clinical Pharmacology, İzmir, Türkiye
Assoc. Prof. Dr. Volkan AYDIN
İstanbul Medipol University International Faculty of Medicine, Department of Medical Pharmacology, İstanbul, Tükiye
Associate Editor
Bölümler
BÖLÜM A: Geriatrik Farmakolojinin Temelleri: Temel Prensipler ve İlaç Araştırmaları
Pharmacokinetic Changes in the Elderly
Celil İlker AŞKIN, Gökçe Sevim ÖZTÜRK FİNCAN
Aşkın Cİ, Öztürk Fincan GS. Pharmacokinetic changes in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.1-4.
Pharmacodynamic Changes in the Elderly
Fatma İŞLİ, Sevil ÖZGER İLHAN
İşli F, Özger İlhan S. Pharmacodynamic changes in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.5-8.
Basic Principles of Rational Use of Drug in the Elderly
Ahmet AKICI, Onur GÜLTEKİN, Caner VIZDIKLAR
Akıcı A, Gültekin O, Vızdıklar C. Basic principles of rational use of drug in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.9-14.
General Aspects of Drug Management in the Geriatric Patient
Nermin KARAKURT, Hacer DOĞAN VARAN
Karakurt N, Doğan Varan H. General aspects of drug management in the geriatric patient. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.15-9.
Prescribing Cascade and Deprescribing
Sibel ÜLKER GÖKSEL
Ülker Göksel S. Prescribing cascade and deprescribing. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.20-6.
Adverse Drug Reactions in the Elderly
Aygül DURDURUR ÇİN, Hakan ERGÜN
Durdurur Çin A, Ergün H. Adverse drug reactions in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.27-30.
Use and Potential Risks of Herbal Products & Supplements in the Elderly
Halit Güner ORHAN, Ş. Remzi ERDEM
Orhan HG, Erdem ŞR. Use and potential risks of herbal products & supplements in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.31-5.
Guidelines for Inappropriate Drug Use in the Elderly
Canan ULUOĞLU, Muhammed Cihan GÜVEL
Uluoğlu C, Güvel MC. Guidelines for inappropriate drug use in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.36-40.
Therapeutic Drug Monitoring in the Elderly
Zeynep Güneş ÖZÜNAL
Özünal ZG. Therapeutic drug monitoring in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.41-4.
Experimental Models of Aging
Alper OKYAR, İ. Halil KAVAKLI, Seval AKYÜREK
Okyar A, Kavaklı İH, Akyürek S. Experimental models of aging. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.45-50.
Characteristics of Clinical Drug Trials in the Elderly
Arzu Güneş GRANBERG
Granberg AG. Characteristics of clinical drug trials in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.51-4.
Novel Drugs for Geriatric Patients
Elif BARIŞ, Yeşim TUNÇOK
Barış E, Tunçok Y. Novel drugs for geriatric patients. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.55-9.
Pharmacoepidemiological Studies in Geriatric Population
Sinem Ezgi GÜLMEZ
Gülmez SE. Pharmacoepidemiological studies in geriatric population. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.60-3.
BÖLÜM B: Sistem Tabanlı Geriatrik Farmakoterapi: Kritik Notlar-Geriatrik Farmakoterapide Özel
Cardiovascular Pharmacotherapy in the Elderly
Volkan AYDIN, N. İpek KIRMIZI SÖNMEZ, Ali Serdar FAK
Aydın V, Kırmızı Sönmez Nİ, Fak AS. Cardiovascular pharmacotherapy in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.64-8.
Pharmacotherapy of Endocrine & Metabolic Disorders in the Elderly
Aylin ARICI, Abdullah Serkan YENER
Arıcı A, Yener AS. Pharmacotherapy of endocrine & metabolic disorders in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.69-72.
Psychiatric Pharmacotherapy in the Elderly
Canan ULUOĞLU, Erhan AKINCI, Gökçen PAYKAL
Uluoğlu C, Akıncı E, Paykal G. Psychiatric pharmacotherapy in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.73-7.
Pharmacotherapy of Respiratory Diseases in the Elderly
İsmail Mert VURAL, İpek Kıvılcım OĞUZÜLGEN
Vural İM, Oğuzülgen İK. Pharmacotherapy of respiratory diseases in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.78-84.
Pharmacotherapy of Gastrointestinal Disorders in the Elderly
Volkan AYDIN, Gökhan TAZEGÜL
Aydın V, Tazegül G. Pharmacotherapy of gastrointestinal disorders in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.85-90.
Pharmacotherapy of Renal and Urinary Problems in the Elderly
Arzu SAYIN ŞAKUL, Kubilay SABUNCU, Rahim HORUZ
Sayın Şakul A, Sabuncu K, Horuz R. Pharmacotherapy of renal and urinary problems in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.91-6.
Pharmacotherapy of Musculoskeletal Conditions in the Elderly
Yeşim GÖKÇE KUTSAL, Tolga Reşat AYDOS
Gökçe Kutsal Y, Aydos TR. Pharmacotherapy of musculoskeletal conditions in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.97-101.
Antimicrobial Pharmacotherapy in the Elderly
Ahmet ALTUN, Gülşah ALTUN
Altun A, Altun G. Antimicrobial pharmacotherapy in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.102-9.
Antineoplastic Pharmacotherapy in the Elderly
Hüseyin Salih SEMİZ, Mukaddes GÜMÜŞTEKİN
Semiz HS, Gümüştekin M. Antineoplastic pharmacotherapy in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.110-5.
Ocular Pharmacotherapy in the Elderly
Mehmet Orkun SEVİK, Berna TERZİOĞLU BEBİTOĞLU
Sevik MO, Terzioğlu Bebitoğlu B. Ocular pharmacotherapy in the elderly. In: Uluoğlu C, ed. Geriatric Pharmacology and Pharmacotherapy. 1st ed. Ankara: Türkiye Klinikleri; 2023. p.116-22.