Current Immunotherapy Landscape for Solid Tumors
The greatest success in cancer treatment in the last decade can undoubtedly be expressed as the discovery of T-cell targeted immunomodulators that block CTLA-4 and PD-1 or PD-L1 immune control points. ”Immune checkpoint inhibitors (ICI)”, which were first used as cancer treatment in 2011, opened a new era in the treatment of cancer patients. T cell targeted immunomodulators are now used alone or in combination with chemotherapy as first or second line treatment agents for about 50 types of cancers. These agents are approved for advanced or metastatic malignant melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cancers, urothelial carcinoma, gastric adenocarcinoma, esophageal cancer, cancer patients with abnormal DNA ratio (MSI-High), classical Hodgkin lymphoma, hepatocellular carcinoma, renal cell carcinoma and have been used in the treatment of many solid and hematological cancers. Indications for use continue to expand rapidly. In recent years, their efficacy have also been demonstrated in the adjuvant treatment of early-stage malignant melanoma, NSCLC and renal cell cancer.
In the last decade, immunotherapy has rapidly taken its place in cancer treatment guidelines with stunning and impressive results, and ICI have begun to be used in the early stages of many solid tumors, especially melanoma, renal cell carcinoma and lung cancer. Studies on new ICI agents, targeted drugs and their combinations are also continuing rapidly. The use of ICI, both in the early and advanced stages, alone or in combination with chemotherapies and targeted therapies, is increasing day by day. In this book, the optimal use of ICI, which have made dazzling developments in recent years, both in advanced and early stages, is explained in details by our professors who are experts in their fields. I hope it will be a useful and productive resource for everyone and I wish you a pleasant reading…
With my love and respect.
Prof. Dr. Mehmet Ali Nahit ŞENDUR
Editor
Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara Bilkent City Hospital, Department of Medical Oncology, Ankara, Türkiye
Bölümler
General Principles of Immunotherapy for Solid Tumors
Erkan ÖZCAN, İrfan ÇİÇİN
Özcan E, Çiçin İ. General principles of immunotherapy for solid tumors. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.1-4.
Biomarkers for Predicting Immunotherapy Efficacy
Fahrettin DUYMUŞ, Taha BAHSİ
Duymuş F, Bahsi T. Biomarkers for predicting immunotherapy efficacy. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.5-11.
Expectations of Oncologist from the Pathologist in Immunotherapy
Nalan AKYÜREK
Akyürek N. Expectations of oncologist from the pathologist in immunotherapy. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.12-7.
Immunotherapy Options for Primary Central Nervous System Tumors
Serhat SEKMEK, Didem ŞENER DEDE
Sekmek S, Şener Dede D. Immunotherapy options for primary central nervous system tumors. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.18-23.
Immunotherapy for Recurrent and Metastatic Head and Neck Cancers
Gözde KAVGACI, Sercan AKSOY
Kavgacı G, Aksoy S. Immunotherapy for recurrent and metastatic head and neck cancers. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.24-30.
Immunotherapy for Locally Advanced or Metastatic Non-Small Cell Lung Carcinoma
Orçun CAN, Gözde KAVGACI, Saadettin KILIÇKAP
Can O, Kavgacı G, Kılıçkap S. Immunotherapy for locally advanced or metastatic non-small cell lung carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.31-7.
Adjuvan or Neoadjuvan Immunotherapy for Non-Small Cell Lung Carcinoma
Yusuf İLHAN, Ali Murat TATLI
İlhan Y, Tatlı AM. Adjuvan or neoadjuvan immunotherapy for non-small cell lung carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.38- 43.
Role of Immunotherapy for Small Cell Lung Cancer
Furkan CEYLAN, Mehmet Ali Nahit ŞENDUR
Ceylan F, Şendur MAN. Role of immunotherapy for small cell lung cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.44-51.
Immunotherapy for Malign Mesothelioma and Other Thoracic Malignancies
Yakup ERGÜN
Ergün Y. Immunotherapy for malign mesothelioma and other thoracic malignancies. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.52-7.
Immunotherapy for Metastatic Breast Cancer
Berkan KARADURMUŞ, Nuri KARADURMUŞ
Karadurmuş B, Karadurmuş N. Immunotherapy for metastatic breast cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.58-64.
Adjuvant and Neoadjuvant Immunotherapy for Breast Cancer
Sabin GÖKTAŞ AYDIN, Ahmet BİLİCİ
Göktaş Aydın S, Bilici A. Adjuvant and neoadjuvant immunotherapy for breast cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.65-71.
Immune Checkpoint Inhibitors for Esophageal Cancer
Perihan PERKİN, Gökhan UÇAR
Perkin P, Uçar G. Immune checkpoint inhibitors for esophageal cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.72-6.
Immunotherapeutic Agents for Gastric Cancer
Hilal KARAKAŞ, Burak BİLGİN
Karakaş H, Bilgin B. Immunotherapeutic agents for gastric cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.77-81.
Immune Efficacy of Immunotherapeutic Agents for Hepatocellular Carcinoma
Murat BARDAKÇI, Mehmet Ali Nahit ŞENDUR
Bardakçı M, Şendur MAN. Immune efficacy of immunotherapeutic agents for hepatocellular carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.82-6.
Immunotherapy Options for Gall Bladder Cancer and Cholangiocarcinoma
Serhat SEKMEK, Burak CİVELEK
Sekmek S, Civelek B. Immunotherapy options for gall bladder cancer and cholangiocarcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.87-91.
Immunotherapy for Renal Cell Carcinoma
Hatice BÖLEK, Yüksel ÜRÜN
Bölek H, Ürün Y. Immunotherapy for renal cell carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.92-8.
Immunotherapy for Metastatic Bladder Carcinoma
Rümeysa ÇOLAK, Deniz TURAL
Çolak R, Tural D. Immunotherapy for metastatic bladder carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.99-105.
Immunotherapy for Metastatic Prostate Carcinoma
Emre YEKEDÜZ
Yekedüz E. Immunotherapy for metastatic prostate carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.106-9.
Immunotherapy for Ovarian/Fallopian Tube Cancer Patients
Elvin CHALABIYEV, Zafer ARIK
Chalabiyev E, Arık Z. Immunotherapy for ovarian/fallopian tube cancer patients. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.110-2.
Immunotherapy for Cervical Cancer
Safa Can EFİL, Muhammed Bülent AKINCI
Efil SC, Akıncı MB. Immunotherapy for cervical cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.113-8.
Immunotherapy for Endometrial Carcinoma
Pınar KUBİLAY TOLUNAY, Cengiz KARAÇİN
Kubilay Tolunay P, Karaçin C. Immunotherapy for endometrial carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.119-23.
Immunotherapy for Malign Melanoma and Other Cutaneous Malignancies
Kaan HELVACI, Umut DEMİRCİ
Helvacı K, Demirci U. Immunotherapy for malign melanoma and other cutaneous malignancies. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.124-9.
Immunotherapy for Rare Solid Tumors and Sarcomas
İrfan KARAHAN, Seda KAHRAMAN, Bülent YALÇIN
Karahan İ, Kahraman S, Yalçın B. Immunotherapy for rare solid tumors and sarcomas. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.130-5.
Radiotherapy Combination with Immunotherapy in Metastatic Solid Tumors
Havva BEYAZ, Yılmaz TEZCAN
Beyaz H, Tezcan Y. Radiotherapy combination with immunotherapy in metastatic solid tumors. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.136-40.
Future Hopes with Immunotherapy Alone or Combinations
Taha Koray ŞAHİN, Deniz Can GÜVEN
Şahin TK, Güven DC. Future hopes with immunotherapy alone or combinations. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.141-6.