Perspectives on Inflammation in Preclinical and Clinical Studies and Current Monitoring: Integration of Inflammation-in vitro Diagnostic Diagnosis, Application, Devices, and Methods

Cancer, infection, and wound healing are three fundamental aspects of medicine, involving nearly all medical branches equally. Interestingly, these three conditions activate similar and common molecular pathways and cellular processes. In a sense, all these processes fall under the umbrella of ”INFLAMMATION”. Due to its complexity and broad scope, this topic has not been sufficiently compiled through common points. In this book, we aim to view diseases through the lens of inflammation.

Defined as a complex biological response of the organism to harmful stimuli, the ”inflammatory response” can also occur in various conditions such as infections, tissue damage, or autoimmune diseases. Understanding and managing the inflammatory response is critically important in both preclinical and clinical studies. In recent years, in vitro diagnostic devices and methods have provided significant advances in the diagnosis and monitoring of inflammation. This book discusses the importance and application areas of integrating preclinical and clinical studies on inflammation with in vitro diagnostic devices and methods.

Preclinical research uses various animal models and cell culture systems to understand the molecular and cellular mechanisms of inflammation. These models are important for evaluating the efficacy and safety of drug candidates. Preclinical studies enable the discovery of new biomarkers that can be used for the early diagnosis and prognosis of inflammation. These biomarkers are thoroughly characterized before being validated in clinical studies.

Accurate and early diagnosis of inflammation in clinical studies plays a critical role in monitoring the course of the disease and the response to treatment. During this process, in vitro diagnostic methods and devices support clinical decisions by providing rapid and precise results at the patient’s bedside. Patient-centered approaches in clinical studies allow for the development of personalized treatment strategies. These approaches are enriched with the data provided by in vitro diagnostic devices.

Significant technological advancements have been made in vitro diagnostic devices, including biosensors, microfluidic devices, and advanced imaging techniques in recent years. These devices enable the precise and rapid detection of inflammation. in vitro diagnostic devices offer a wide range of applications in laboratory settings. The detection of inflammatory biomarkers in blood, urine, or other biological samples is one of the most common uses of these devices.

The integration of preclinical and clinical studies with in vitro diagnostic devices and methods requires multidisciplinary approaches. This integration involves the collaboration of biomedical engineering, clinical medicine, bioinformatics, and other fields. The importance of inflammation in personalized medicine is increasing. Customized treatment approaches according to individual patient profiles become possible with the use of in vitro diagnostic data.

The current monitoring of preclinical and clinical studies on inflammation and the combined use of in vitro diagnostic devices and methods offer significant advantages in disease diagnosis and treatment. This integration contributes to the development of more effective and personalized approaches to patient treatment processes. In the future, technological advancements and multidisciplinary collaborations will further develop this field.

In this book, the integration of preclinical and clinical studies on inflammation with in vitro diagnostic methods is discussed in a multidisciplinary and comprehensive manner, examining inflammation from different perspectives, from basic research to clinical applications. By emphasizing the potential of this field, which offers innovative approaches to the diagnosis and treatment of inflammation, from research laboratories to clinical patient management, we hope to inspire and guide researchers, clinicians, and students.

We aim to contribute to the development of more effective treatment methods by providing the necessary knowledge and tools to understand and manage the complex nature of inflammation. By discussing the opportunities and challenges provided by the integration of preclinical and clinical studies with in vitro diagnostic devices and methods, we hope to lay a foundation for future research in this area.

We extend our gratitude to all researchers, clinicians, and health professionals who inspired and supported us in preparing this book. By sharing our knowledge in this field, we hope to open new horizons in the understanding and management of inflammation.

Respectfully.

Prof. Dr. Hilal KOÇDOR
Editor
Dokuz Eylül University Institute of Oncology, Department of Basic Oncology İzmir, Türkiye

Prof. Dr. Aysun PABUÇÇUOĞLU
Editor
Ege University Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, İzmir, Türkiye

Prof. Dr. Figen ZİHNİOĞLU
Editor
Ege University Faculty of Science, Department of Biochemistry, İzmir, Türkiye

PRESENTATION

This book, prepared by Türkiye Klinikleri, is a resource containing valuable information about what our immune system is and how it works, summarized by our esteemed scientists.

Inflammation is a word derived from the Latin word ”inflammare”, which began to be used in the seventeenth century, meaning to have the property of burning on its own. The word used for inflammation in Turkish is ”yangı” and there is also the concept of burning in this word.

The immune system is a protection and defense system by which living things defend themselves against external factors, and the dimension discussed in this book is about inflammation, that is, the response of any foreign substance when it penetrates the living body and/or the reactive products of body, because this response is the key to survival. In this book, current information, and methods regarding the body’s responses to factors that cause sudden changes in the immune system, which can be any inorganic or organic factor, and the analysis of their results are discussed. The need to develop these methods is also emphasized. Although this resource, which provides topic headings for young scientists who will address these issues in the future, consists of articles dealing with in vitro methods, it is a guiding resource in which in vivo studies are also highlighted with visuals. I recommend that young scientists who evaluate this book through the electronic edition should consider the inter-chapter associations of parameters and concepts simultaneously.

We hope that this resource presented to our young scientists will ignite their curiosity and be a guide on their route.

Prof. Dr. Yahya Rauf LALELİ