Adjuvant and Neoadjuvant Immunotherapy for Breast Cancer

tibbionko-17-1-kapak

Sabin GÖKTAŞ AYDINa , Ahmet BİLİCİb
aİstanbul Kanuni Sultan Süleyman Training and Research Hospital, Clinic of Medical Oncology, İstanbul, Türkiye
bİstanbul Medipol University Faculty of Medicine, Department of Medical Oncology, İstanbul, Türkiye

Göktaş Aydın S, Bilici A. Adjuvant and neoadjuvant immunotherapy for breast cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.65-71.

Adjuvant and Neoadjuvant Immunotherapy for Breast Cancer

Meme Kanserinde Adjuvan ve Neoadjuvan İmmünoterapi

Sabin GÖKTAŞ AYDINa , Ahmet BİLİCİb
aİstanbul Kanuni Sultan Süleyman Training and Research Hospital, Clinic of Medical Oncology, İstanbul, Türkiye
bİstanbul Medipol University Faculty of Medicine, Department of Medical Oncology, İstanbul, Türkiye

Göktaş Aydın S, Bilici A. Adjuvant and neoadjuvant immunotherapy for breast cancer. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.65-71.

Makale Dili: EN

Ücretsiz Erişim

ABSTRACT
Breast cancer, the most common malignancy in women, necessitates a comprehensive approach involving surgery, medical oncology, and radiation oncology. The AJCC staging incorporates biologic features alongside TNM classification to determine the cancer stage. Early and locally advanced breast cancer requires systemic treatment to reduce the risk of recurrence. Achieving pathological complete response (pCR) through neoadjuvant therapy is a strong prognostic factor. Immunotherapy, targeting PD-1/PD-L1 has shown promise, particularly in triple-negative breast cancer (TNBC). KEYNOTE-522 study demonstrated improved pCR and event-free survival (EFS) rates with pembrolizumab in neoadjuvant setting. Atezolizumab, when combined with nab-paclitaxel, increased pCR rates in IMPASSION031 trial. While neoadjuvant immunotherapy presents potential advantages, the safety profile and long-term efficacy are still evolving. Future studies should focus on optimal treatment duration and sequencing, especially in adjuvant settings.

Keywords: Breast cancer; immunotherapy; adjuvant treatment; neoadjuvant treatment

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