Aging and Microplastics

Hadi SAYEDYOUSEFa , Becen DEMİRb , Hilal TOYGARa
aİstanbul Medipol University Faculty of Dentistry, Department of Periodontology, İstanbul, Türkiye
bPrivate Dentist, İstanbul, Türkiye

Sayedyousef H, Demir B, Toygar H. Aging and microplastics. In: Toygar H, Balcı N, eds. Exposure to Microplastics in Life and Dentistry. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.31-5.

ABSTRACT
This section delves into the intricate relationship between microplastics and aging, illuminating potential consequences for cellular health. Aging, marked by progressive physiological decline, is influenced by molecular changes such as heightened inflammation and reactive oxygen species (ROS) generation. Microplastics, prevalent environmental pollutants, pose concerns as evidence suggests constant human exposure. Researches have shown that microplastics accelerate aging, impacting lifespan and aging markers. Mechanistically, this involves modulating apoptotic pathways and contributing to cellular senescence. Microplastics induce ROS, causing DNA damage and mitochondrial dysfunction, linking to cellular dysfunction and inflammation associated with shortened lifespans. Understanding the impact of microplastics on the aging process is crucial for developing targeted interventions and formulating strategies to minimize their effects on cellular senescence and overall health.

Keywords: Microplastics; aging; apoptosis; cellular senescence; reactive oxygen species

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