Anafilakside Triptaz ve Diğer Biyolojik Belirteçler

immunoloji alerji ozel 13-3 kapak

Zeynep GÜLEÇ KÖKSALa, Pınar UYSALa
aAydın Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk İmmünolojisi ve Alerji Hastalıkları BD, Aydın, TÜRKİYE

Güleç Köksal Z, Uysal P. Anafilakside triptaz ve diğer biyolojik belirteçler. Akın C, Şekerel BE. editörler. Anafilaksi. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.12-7.

ÖZET
Anafilaksi, çocuk ve erişkinlerde ölüm riski taşıyan en ciddi sistemik alerjik reaksiyondur. Anafilakside doğru tanı ve tedavi yaklaşımı hastanın hayatını kurtarmak için oldukça önemlidir. Ancak, hastalık diğer klinik durumlar ile karıştırılabilir. Günümüzde, anafilaksiyi tetikleyen alerjenin türüne bakılmaksızın tanıyı kesin olarak doğrulayan bir biyolojik belirteç bulunmamaktadır. Laboratuvar yöntemleri anafilaksi tanısında sınırlı bir yere sahiptir. Ürtiker ve anjioödem olmaksızın ani gelişen kollaps ve şok durumlarında biyolojik belirteçlerin önemi daha da artmaktadır. Anafilaksi esnasında mast hücre ve bazofillerin degranülasyonu sonucu birçok farklı biyokimyasal mediyatör, kemokin ve sitokin salınır. Mast hücre aktivasyonunu değerlendirmede en iyi biyolojik belirteç triptaz kabul edilmektedir. Burada anafilakside rol oynayan kimyasal mediyatörler ile anafilaksi tanı ve izleminde kullanılabilecek biyolojik belirteçleri sunmayı amaçladık.

Anahtar Kelimeler: Anafilaksi; biyolojik belirteç; mast hücre; triptaz

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