ANESTHESIOLOGY FAST REVIEW

ANESTHESIOLOGY_FAST_REVIEWKAPAK1-0-25

ANALGESIC AGENTS

Cem Kıvılcım Kaçar

Diyarbakır Gazi Yaşargil Training and Research Hospital, Department of Anesthesiology and Reanimation, Diyarbakır, Türkiye

Kaçar CK. Analgesic Agents. In: Kazancı D, editor. Anesthesiology Fast Review. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.149-159.

ABSTRACT

  • Opioid analgesics remain a cornerstone in the management of severe pain but require careful consideration of receptor pharmacology, pharmacokinetics, and patient variability.
  • Advancements in pharmacogenetics and clinical pharmacology help optimize opioid therapy by balancing efficacy with risk mitigation.
  • The development of abuse-deterrent opioid formulations and multimodal analgesia strategies aims to improve both safety and effectiveness.
  • Continuous research and vigilant clinical practice are essential to address opioid-related complications and enhance pain management approaches.
  • Cyclooxygenase inhibitors (NSAIDs) play a crucial role in pain management by reducing inflammation through prostaglandin inhibition.
  • Gabapentinoids such as gabapentin and pregabalin effectively manage neuropathic pain by modulating voltage-gated calcium channels.
  • A multimodal pain management approach incorporating NSAIDs and gabapentinoids can reduce opioid dependence and improve analgesic outcomes.
  • Future research and innovation in analgesic therapies will drive more personalized and safer pain management strategies.

Keywords: Analgesia; Anesthesia; Pain management; Opioids; Nonsteroidal anti-inflammatory agents

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