CURRENT CONCEPTS IN RADIOTHERAPY FOR BENIGN DISORDERS

CurrentConceptsinRadiotherapyforBenignDisorders1-0-25kapak

Aneurysmal Bone Cyst

Serra KAMERa , Fatma SERTa
aEge University Faculty of Medicine, Department of Radiation Oncology, İzmir, Türkiye

Kamer S, Sert F. Aneurysmal bone cyst. In: Uysal B, Gamsız H, eds. Current Concepts in Radiotherapy for Benign Disorders. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.43-6.

ABSTRACT
An aneurysmal bone cyst (ABC) is a non-cancerous bone growth characterized by bloodfilled channels separated by fibrous septa. This condition can cause rapid damage, especially in young individuals, and the main symptom is localized pain due to the breakdown of bone tissue. Larger growths may result in bone fractures and nerve issues. Surgical procedures are the standard treatment for ABCs, but they often have high local relapse rates. Adjuvant treatments aim to reduce relapse rates, and radiotherapy is recommended for operable cases or as additional treatment for recurrent or incompletely removed cases, with promising outcomes.

Keywords: Radiotherapy; bone cysts, aneurysmal

Referanslar

  1. Leithner A, Windhager R, Lang S, Haas O, Kainberger F, Kotz R. Aneurysmal bone cyst. A population based epidemiologic study and literature review. Clin Orthop. 1999;363:176-9. [Crossref]
  2. Jaffe HL. Solitary unicameral bone cyst. Arch Surg. 1942:44(6):1004. [Crossref]
  3. Tsagozis P, Brosjö O. Current strategies for the treatment of aneurysmal bone cysts. Orthop Rev (Pavia). 2005;7(4):6182.
  4. Oliveira SM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, et al. USP6 (tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res. 2004a;64:1920-3. [Crossref]  [PubMed]
  5. Nasri E, Reith JD. Aneurysmal bone cyst: a review. J Pathol Transl Med. 2023;57(2):81-7. [Crossref]  [PubMed]  [PMC]
  6. Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005;23(27):6756-62. [Crossref]  [PubMed]
  7. Enneking WF. A system of staging musculoskeletal neoplasms. Clin Orthop. 1986;204:9-24. [Crossref]
  8. Lange T, Stehling C, Frohlich B, et al. Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts. Eur Spine J. 2013;22: 1417-22. [Crossref]  [PubMed]  [PMC]
  9. Elsayad K, Kriz J, Seegenschmiedt H, Imhoff D, Heyd R, Eich HT, et al. Radiotherapy for aneurysmal bone cysts: a rare indication. Strahlenther Onkol. 2017;193(4):332-40. [Crossref]  [PubMed]
  10. Nobler MP, Higinbotham NL, Phillips RF. The cure of aneurysmal bone cyst. Irradiation superior to surgery in an analysis of 33 cases. Radiology 1968;90(6):1185-92. [Crossref]  [PubMed]
  11. Taylor FW. Aneurysmal bone cyst. report of three cases. ] Bone Joint surg [Br]. 1956;38-B:293-300. [Crossref]  [PubMed]
  12. Reichl B, Block A, Schäfer U, Bert C, Müller R, Jung H, et al; German cooperative Group on radiotherapy for Benign Diseases (GCG-BD). DEGRO practical guidelines for radiotherapy of non-malignant disorders: Part I: physical principles, radiobiological mechanisms, and radiogenic risk. Strahlenther Onkol. 2015;191(9):701-9. [Crossref]  [PubMed]
  13. Marcove RC, Sheth DS, Takemoto S, Healey JH. The treatment of aneurysmal bone cyst. Clin Orthop Relat Res. 1995;(311):157-63.
  14. Boriani S, De Iure F, Campanacci L, Gasbarrini A, Bandiera S, Biagini R, et al. Aneurysmal bone cyst of the mobile Spine: Report on 41 cases. Spine (Phila Pa 1976). 2001;26(1):27-35. [Crossref]  [PubMed]
  15. Feigenberg SJ, Marcus RB Jr, Zlotecki RA, Scarborough MT, Berrey BH, Enneking WF. Megavoltage radiotherapy for aneurysmal bone cysts. Int J Radiat Oncol Biol Phys. 2001;49(5):1243-7. [Crossref]  [PubMed]
  16. Başarir K, Pişkin A, Güçlü B, Yildiz Y, Sağlik Y. Aneurysmal bone cyst recurrence in children: a review of 56 patients. J Pediatr Orthop. 2007;27(8):938-43. [Crossref]  [PubMed]
  17. Zhu S, Hitchcock KE, Mendenhall WM. radiation therapy for aneurysmal Bone Cysts. Am J Clin Oncol. 2017;40(6):621-4. [Crossref]  [PubMed]