PULMONARY PATHOLOGIES AND MANAGEMENT STRATEGIES IN PRIMARY IMMUNODEFICIENCIES

pulmonary_pathologies_kapak

BACTERIAL AND VIRAL PULMONARY INFECTIONS IN PRIMARY IMMUNODEFICIENCIES

Seçim Kolak1 Sümeyra Alan Yalım2

1Konya Necmettin Erbakan University, Faculty of Medicine, Department of Immunology and Allergic Diseases, Konya, Türkiye
2Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Immunology and Allergic Diseases, Afyonkarahisar, Türkiye

Kolak S, Alan Yalım S. Bacterial and Viral Pulmonary Infections in Primary Immunodeficiencies. In: Arslan Ş editor. Pulmonary Pathologies and Management Strategies in Primary Immunodeficiencies. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.33-43.

ABSTRACT

One of the most prominent clinical features of primary immunodeficiencies (PIDs) is the increased susceptibility to recurrent and severe pulmonary infections of bacterial and viral origin. These infections often constitute the earliest clinical manifestations of PIDs and significantly contribute to long-term morbidities such as bronchiectasis and interstitial lung disease. This chapter reviews the clinical characteristics, immunopathogenesis, and diagnostic approaches of bacterial and viral respiratory infections in PIDs. It also discusses infection patterns associated with distinct immunological defects and emphasizes the importance of early diagnosis, targeted antimicrobial therapy, and long-term respiratory monitoring. A better understanding of these infections in the context of PIDs is crucial for improving clinical outcomes and guiding personalized treatment strategies.

Keywords: Primary immunodeficiency; Pulmonary infections; Bacterial and viral respiratory infections; Bronchiectasis; Interstitial lung disease; Antimicrobial therapy

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