ADVANCED TECHNOLOGIES IN ORAL AND MAXILLOFACIAL SURGERY

MaxillofacialSurgerydakapak

CHALLENGES AND FUTURE DIRECTIONSIN BIOMATERIALS AND REGENERATIVE APPLICATIONS

Semih Ayrıkçil

Nevşehir Hacı Bektaş Veli University, Faculty of Densistry, Department of Oral and Maxillofacial Surgery, Nevşehir, Türkiye

Ayrıkçil S. Challenges and Future Directions in Biomaterials and Regenerative Applications. Karasu HA, ed. Advanced Technologies in Oral and Maxillofacial Surgery. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.8597.

ABSTRACT

Regenerative engineering involves the application of biological technologies and technical approaches to facilitate the rehabilitate and restoration of diverse cells, tissues, and organs. Bone regeneration technologies encompass a range of approaches, including cellulosebased biomaterials, stem cell ther apies, growth factor treatments, plateletrich fibrin (PRF) therapy, as well as the use of artificial intel ligence and 3D printing. Artificial Intelligence (AI) can be used for tissue regeneration and repair. AI has become an essential component of the medical field. The significance of renewable biomaterials in dentistry has developed significantly in lately, largely due to heightened sustainability issues, resource shortage, waste pileup, and the growing requisition for biocompatible components. Cellulose, the most widespread organic polymer on Earth. Because of its biocompatibility, biodegradability, and favorable mechanical qualities, cellulose is wellsuited for a variety of uses, including in dentistry. The develop ment in stem cells have opened the door for incorporating biological methods into dentistry, with the aim of rebuilding damaged dental systems. Bone generated via stem cell treatments is not only ample besides of excellence, presenting solidness and widespread blood supply. Various bone regeneration techniques have been suggested to allow more successful longterm implantsupported rehabilitations. The development of new bone augmentation ways, including the use of growth factors, to enhance bone regeneration and address these challenges. Growth factors, have attracted intense focus in dental surgery due to their capability to improve tissue regeneration and accelerate wound healing processes. APRF is derived from the patient’s own venous blood before surgery, eliminating the risk of antigen reactions during graft placement and integration. APRF positively influences both soft and hard tis sues. APRF is primarily used in various surgical procedures, particularly in oral and maxillofacial surgery. Digitization has become essential in daily life, including in the healthcare fields. It provides an productive, reliable, costeffective, userfriendly, and ecofriendly approach to task and production management. The integration of digital technologies in implant dentistry.

The integration of 3D printing technology into dental surgery has significantly improved overall treat ment results and presurgical planning. This progress is especially noticable in the creation of personal ized surgical guides, scaffolds, titanium meshes, bone grafts, and dental implant components. The field of biomaterials and regenerative applications in oral surgery is evolving rapidly. As the advancements continue, we may see more effective and personalized treatments that enhance healing, reduce compli cations, and improve patient outcomes in oral surgery.

Keywords: Biocompatible materials; Cellulose; Mesenchymal stem cells; Bone regeneration;

Artificial intelligence; Bioprinting; Plateletrich fibrin

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