Climate Change and Neurological Disorders in Children

Müge AYANOĞLUa , Ayşe Fahriye TOSUNa

aAydın Adnan Menderes University Faculty of Medicine, Department of Pediatric Neurology, Aydın, Türkiye

ABSTRACT
The review article discusses the impact of climate change on pediatric patients with neurological disorders. Climate change, characterized by global warming caused by increasing gases such as CO2, CH4 and N2O, changes in precipitation patterns, and extreme weather events, is caused by increasing greenhouse gas concentrations. These changes are linked to a rise in infectious diseases with neurological disorders. Environmental neurotoxins, exacerbated by climate change, could accelerate neurodegenerative disorders. Malnutrition arising from disrupted agriculture threatens neurodevelopmental health. Elevated environmental temperatures increase the risk of metabolic and neurological abnormalities. The vulnerability of individuals with pre-existing neurological conditions, such as epilepsy and disabilities, has been discussed in details. The need for preventative actions, education, public awareness, and legal frameworks to mitigate climate change’s adverse impact on neurological health has been emphasized.
Keywords: Climate change; global warming; nervous system diseases; child

Referanslar

  1. Agreement P, editor Paris agreement. report of the conference of the parties to the United Nations framework convention on climate change (21st session, 2015: Paris) Retrived December; 2015: HeinOnline.
  2. Organization WH. COP24 special report: health and climate change. 2018.
  3. IPPC. IPCC Report Global Warming of 1.5° C. IPPC Rome, Italy; 2018.
  4. Hallegatte S, Green C, Nicholls RJ, Corfee-Morlot J. Future flood losses in major coastal cities. Nature climate change. 2013;3(9):802-6. [Crossref]
  5. Burrows K, Kinney PL. Exploring the climate change, migration and conflict nexus. International journal of environmental research and public health. 2016;13(4):443. [Crossref]  [PubMed]  [PMC]
  6. Kinney PL. Interactions of climate change, air pollution, and human health. Current environmental health reports. 2018;5:179-86. [Crossref]  [PubMed]
  7. Canavan BC. Opening Pandora's Box at the roof of the world: Landscape, climate and avian influenza (H5N1). Acta tropica. 2019;196:93-101. [Crossref]  [PubMed]
  8. Caminade C, McIntyre KM, Jones AE. Impact of recent and future climate change on vector‐borne diseases. Annals of the New York Academy of Sciences. 2019;1436(1):157-73. [Crossref]  [PubMed]  [PMC]
  9. Kleinschmidt‐DeMasters BK, Beckham JD. West N ile Virus Encephalitis 16 Years Later. Brain Pathology. 2015;25(5):625-33. [Crossref]  [PubMed]  [PMC]
  10. Ryan SJ, Carlson CJ, Mordecai EA, Johnson LR. Global expansion and redistribution of Aedes-borne virus transmission risk with climate change. PLoS neglected tropical diseases. 2019;13(3):e0007213. [Crossref]  [PubMed]  [PMC]
  11. Depoux A, Philibert A, Rabier S, Philippe H-J, Fontanet A, Flahault A. A multi-faceted pandemic: A review of the state of knowledge on the Zika virus. Public health reviews. 2018;39(1):1-12. [Crossref]  [PubMed]  [PMC]
  12. Garkowski A, Zajkowska J, Zajkowska A, Kułakowska A, Zajkowska O, Kubas B, et al. Cerebrovascular manifestations of lyme neuroborreliosis-a systematic review of published cases. Frontiers in Neurology. 2017;8:146. [Crossref]  [PubMed]  [PMC]
  13. Ruszkiewicz JA, Tinkov AA, Skalny AV, Siokas V, Dardiotis E, Tsatsakis A, et al. Brain diseases in changing climate. Environmental research. 2019;177:108637. [Crossref]  [PubMed]  [PMC]
  14. Levy K, Woster AP, Goldstein RS, Carlton EJ. Untangling the impacts of climate change on waterborne diseases: a systematic review of relationships between diarrheal diseases and temperature, rainfall, flooding, and drought. Environmental science & technology. 2016;50(10):4905-22. [Crossref]  [PubMed]  [PMC]
  15. Cope JR, Ratard RC, Hill VR, Sokol T, Causey JJ, Yoder JS, et al. The first association of a primary amebic meningoencephalitis death with culturable Naegleria fowleri in tap water from a US treated public drinking water system. Clinical Infectious Diseases. 2015;60(8):e36-e42. [Crossref]  [PubMed]  [PMC]
  16. Cope JR, Ali IK. Primary amebic meningoencephalitis: what have we learned in the last 5 years? Current infectious disease reports. 2016;18:1-7. [Crossref]  [PubMed]  [PMC]
  17. Van Oostdam J, Gilman A, Dewailly E, Usher P, Wheatley B, Kuhnlein
  18. Ramsdell JS, Gulland FM. Domoic acid epileptic disease. Marine drugs. 2014;12(3):1185-207. [Crossref]  [PubMed]  [PMC]
  19. Myers SS, Smith MR, Guth S, Golden CD, Vaitla B, Mueller ND, et al. Climate change and global food systems: potential impacts on food security and undernutrition. Annual review of public health. 2017;38:259-77. [Crossref]  [PubMed]
  20. Guerrant RL, Oriá RB, Moore SR, Oriá MO, Lima AA. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutrition reviews. 2008;66(9):487-505. [Crossref]  [PubMed]  [PMC]
  21. Pallotta MM, Turano M, Ronca R, Mezzasalma M, Petraccioli A, Odierna G, et al. Brain gene expression is influenced by incubation temperature during leopard gecko (Eublepharis macularius) development. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2017;328(4):360-70. [Crossref]  [PubMed]
  22. Titus DJ, Furones C, Atkins CM, Dietrich WD. Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia. Experimental neurology. 2015;263:254-62. [Crossref]  [PubMed]  [PMC]
  23. Hermstad E, Adams B. Traumatic brain injury complicated by environmental hyperthermia. Journal of emergencies, trauma and shock. 2010;3(1):66. [Crossref]  [PubMed]  [PMC]
  24. Lei L, Bao J, Guo Y, Wang Q, Peng J, Huang C. Effects of diurnal temperature range on first-ever strokes in different seasons: a time-series study in Shenzhen, China. BMJ open. 2020;10(11):e033571. [Crossref]  [PubMed]  [PMC]
  25. Ascherio A, Munger KL, Simon KC. Vitamin D and multiple sclerosis. The Lancet Neurology. 2010;9(6):599-612. [Crossref]  [PubMed]
  26. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of Clinical Endocrinology & Metabolism. 2011;96(1):53-8. [Crossref]  [PubMed]  [PMC]
  27. Bivona G, Gambino CM, Iacolino G, Ciaccio M. Vitamin D and the nervous system. Neurological research. 2019;41(9):827-35. [Crossref]  [PubMed]
  28. Kraus FB, Medenwald D, Ludwig-Kraus B. Do extreme summers increase blood vitamin D (25-hydroxyvitamin D) levels? PLoS One. 2020;15(11):e0242230. [Crossref]  [PubMed]  [PMC]
  29. Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, et al. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology. 2021;20(10):795-820. [Crossref]  [PubMed]
  30. Akanwake JB, Atinga RA, Boafo YA. Effect of climate change on cerebrospinal meningitis morbidities and mortalities: A longitudinal and community-based study in Ghana. PLOS Climate. 2022;1(8):e0000067. [Crossref]
  31. Chen J, Jiao Z, Liang Z, Ma J, Xu M, Biswal S, et al. Association between temperature variability and global meningitis incidence. Environment international. 2023;171:107649. [Crossref]  [PubMed]
  32. Dravet C, Guerrini R. Dravet syndrome: John Libbey Eurotext; 2013.
  33. Gulcebi MI, Bartolini E, Lee O, Lisgaras CP, Onat F, Mifsud J, et al. Climate change and epilepsy: Insights from clinical and basic science studies. Epilepsy & Behavior. 2021;116:107791. [Crossref]  [PubMed]  [PMC]
  34. Hallab A, Sen A. Epilepsy and psychogenic non-epileptic seizures in forcibly displaced people: A scoping review. Seizure. 2021;92:128-48. [Crossref]  [PubMed]
  35. Mukamal KJ, Wellenius GA, Suh HH, Mittleman MA. Weather and air pollution as triggers of severe headaches. Neurology. 2009;72(10):922-7. [Crossref]  [PubMed]  [PMC]
  36. Neut D, Fily A, Cuvellier J-C, Vallée L. The prevalence of triggers in paediatric migraine: a questionnaire study in 102 children and adolescents. The journal of headache and pain. 2012;13:61-5. [Crossref]  [PubMed]  [PMC]
  37. Louis S, Carlson AK, Suresh A, Rim J, Mays M, Ontaneda D, et al. Impacts of climate change and air pollution on neurologic health, disease, and practice: a scoping review. Neurology. 2023;100(10):474-83. [Crossref]  [PubMed]  [PMC]
  38. Mohr DC, Hart SL, Julian L, Cox D, Pelletier D. Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis. Bmj. 2004;328(7442):731. [Crossref]  [PubMed]  [PMC]
  39. Byun S, Myung W, Kim H, Lee H. Association between diurnal temperature range and emergency department visits for multiple sclerosis: a time-stratified case-crossover study. Science of The Total Environment. 2020;720:137565. [Crossref]  [PubMed]
  40. Elser H, Parks RM, Moghavem N, Kiang MV, Bozinov N, Henderson VW, et al. Anomalously warm weather and acute care visits in patients with multiple sclerosis: A retrospective study of privately insured individuals in the US. PLoS Medicine. 2021;18(4):e1003580. [Crossref]  [PubMed]  [PMC]
  41. Sisodiya SM. Climate change and the brain. Brain. 2023;146(5):1731-3. [Crossref]  [PubMed]  [PMC]
  42. Hsieh SL, Shultz JM, Briggs F, Espinel Z, Shapiro LT. Climate Change and the Urgent Need to Prepare Persons With Multiple Sclerosis for Extreme Hurricanes. International Journal of MS Care. 2023. [Crossref]  [PubMed]  [PMC]