Complications of Botulinum Toxin and Fillers
Furkan ALTAŞ
University of Health Sciences Faculty of Medicine Ankara Bilkent City Hospital, Department of Emergency Medicine, Ankara, Türkiye
Nilay ILIKÇA ALTAŞ
University of Health Sciences Faculty of Medicine, Gülhane Training and Research Hospital, Department of Plastic, Aesthetic and Reconstructive Surgery, Ankara, Türkiye
Altaş F, Ilıkça Altaş N. Complications of botulinum toxin and fillers. In: Oğuztürk H, Görmeli Kurt N, eds. Dermatologic Emergencies. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.109-15.
ABSTRACT
Injectable treatments have significantly surged due to the increasing demand worldwide for appearing beautiful and youthful. Such as botulinum toxin and dermal fillers have become more popular due to their rapid, well-defined, and long-lasting results in reducing fine lines, wrinkles, and rejuvenating the face. Complications of botulinum toxin and dermal fillers are critical considerations in both medical and cosmetic practices. These injectable treatments, while widely utilized for their effectiveness in reducing wrinkles, softening facial lines, and treating various medical conditions, are not devoid of risks. Adverse effects can range from minor to severe, influenced by factors such as injection site, dosage, patient history, and the expertise of the practitioner. Botulinum toxin used for conditions like chronic migraines, muscle spasms, and cosmetic enhancements, can also lead to complications if the toxin spreads to unintended muscles. Common issues include drooping eyelids, double vision, difficulty swallowing, and, in severe cases, respiratory distress or even blindness. Dermal fillers, used primarily for soft tissue augmentation in areas like the face and hands, also present a spectrum of potential complications. These range from mild, transient effects such as redness, bruising, and swelling, to more severe outcomes like vascular compromise, infections, and granulomatous reactions. Overall, while botulinum toxin and dermal fillers offer significant benefits in both therapeutic and aesthetic contexts, their potential for complications necessitates a thorough understanding of the risks and meticulous attention to procedural details. By adhering to established safety protocols and promptly managing adverse events, healthcare providers can optimize treatment outcomes and minimize the occurrence of serious complications.
Keywords: Botulinum toxin; dermal fillers; komplikasyonlar
Kaynak Göster
Referanslar
- Nigam PK, Nigam A. Botulinum toxin. Indian J Dermatol. 2010;55(1):8-14. [Crossref] [PubMed] [PMC]
- American Society of Plastic Surgeons ® Endorsed Partner Statistic. [Internet]. 2024 [2024: 15 august]. Retrieved from [Link]
- Hallett M. Explanation of timing of botulinum neurotoxin effects, onset and duration, and clinical ways of influencing them. Toxicon. 2015;107(Pt A):64- 7. [Crossref] [PubMed] [PMC]
- Botox injection: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. [Internet]. 2024 [2024: 17 august]. Retrieved from [Link]
- Dayan SH, Ian Newberry C, Cerrati EW, Ashourian N. Complications of Botulinum Toxin A: A Comprehensive Review. Scholarly J Otolaryngol. 2018;1(1). [Crossref]
- Botulinum Toxin. [Internet]. 2024 [2024: 15 august]. Retrieved from [Link]
- Botox for Medical Purposes: Side Effects, Uses, Cost, and More. [Internet]. 2024 [2024: 17 august]. [Link]
- Vartanian AJ, Dayan SH. Complications of botulinum toxin A use in facial rejuvenation. Facial Plast Surg Clin North Am. 2005;13(1):1-10. [Crossref] [PubMed]
- Ward NL, Kavlick KD, Diaconu D, Dawes SM, Michaels KA, Gilbert E. Botulinum neurotoxin A decreases infiltrating cutaneous lymphocytes and improves acanthosis in the KC-Tie2 mouse model. J Invest Dermatol. 2012;132(7):1927-30. [Crossref] [PubMed] [PMC]
- Shetty MK; IADVL Dermatosurgery Task Force. Guidelines on the use of botulinum toxin type A. Indian J Dermatol Venereol Leprol. 2008;74 Suppl:S13- 22. [Crossref] [PubMed]
- Small R. Botulinum toxin injection for facial wrinkles. Am Fam Physician. 2014;90(3):168-75. [PubMed]
- Yiannakopoulou E. Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin. Pharmacology. 2015;95(1-2):65-9. [Crossref] [PubMed]
- Witmanowski H, Błochowiak K. The whole truth about botulinum toxin - a review. Postepy Dermatol Alergol. 2020;37(6):853-61. [Crossref] [PubMed] [PMC]
- Peter Peng HL. Masseter Hypertrophy: Toxin Treatment Techniques, Causes of Complications, and Prevention. IntechOpen. 2018. [Crossref]
- Delle Chiaie T. Diplopia Secondary to Neurotoxin Injections: Prevention, Diagnosis, and Management. J Clin Aesthet Dermatol. 2024;17(3-4 Suppl 1):S30-S6. [PMC]
- Coté TR, Mohan AK, Polder JA, Walton MK, Braun MM. Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases. J Am Acad Dermatol. 2005;53(3):407-15. [Crossref] [PubMed]
- Paget SP, Swinney CM, Burton KLO, Bau K, O'Flaherty SJ. Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy. Dev Med Child Neurol. 2018;60(11):1172-7. [Crossref] [PubMed]
- Bai L, Peng X, Liu Y, Sun Y, Wang X, Wang X, et al. Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT). Medicine (Baltimore). 2018;97(34):e10659. [Crossref] [PubMed] [PMC]
- Varghese-Kroll E, Elovic EP. Contralateral weakness and fatigue after highdose botulinum toxin injection for management of poststroke spasticity. Am J Phys Med Rehabil. 2009;88(6):495-9. [Crossref] [PubMed]
- Simons FE, Ardusso LR, Bilò MB, El-Gamal YM, Ledford DK, Ring J, et al.; World Allergy Organization. World allergy organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011;4(2):13-37. [Crossref] [PubMed] [PMC]
- Liu K. Dermal fillers: The good, the bad and the dangerous - Harvard Health. [Internet]. 2024 [2024 15 August]. Retrieved from: [Link]
- Dermal Fillers: What They Are, Types, Benefits & Side Effects. [Internet]. 2024 [2024: 15 august]. Retrieved from [Link]
- Sánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. Materiales de relleno: tipos, indicaciones y complicaciones [Dermal fillers: types, indications, and complications]. Actas Dermosifiliogr. 2010;101(5):381-93. Spanish. [Crossref] [PubMed]
- Abduljabbar MH, Basendwh MA. Complications of hyaluronic acid fillers and their managements. J Dermatol. 2016;20(2):100-6. [Crossref]
- Lafaille P, Benedetto A. Fillers: contraindications, side effects and precautions. J Cutan Aesthet Surg. 2010;3(1):16-9. [Crossref] [PubMed] [PMC]
- Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg. 2008;34 Suppl 1:S92-9. [Crossref] [PubMed]
- Robati RM, Moeineddin F, Almasi-Nasrabadi M. The Risk of Skin Necrosis Following Hyaluronic Acid Filler Injection in Patients With a History of Cosmetic Rhinoplasty. Aesthet Surg J. 2018;38(8):883-8. [Crossref] [PubMed]
- Daines SM, Williams EF. Complications associated with injectable soft-tissue fillers: a 5-year retrospective review. JAMA Facial Plast Surg. 2013;15(3):226- 31. [Crossref] [PubMed]
- Cassuto D, Sundaram H. A problem-oriented approach to nodular complications from hyaluronic acid and calcium hydroxylapatite fillers: classification and recommendations for treatment. Plast Reconstr Surg. 2013;132(4 Suppl 2):48S-58S. [Crossref] [PubMed]
- Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol. 2013;6:295-316. [Crossref] [PubMed] [PMC]
- Kassir R, Kolluru A, Kassir M. Extensive necrosis after injection of hyaluronic acid filler: case report and review of the literature. J Cosmet Dermatol. 2011;10(3):224-31. [Crossref] [PubMed]
- Lemperle G, Rullan PP, Gauthier-Hazan N. Avoiding and treating dermal filler complications. Plast Reconstr Surg. 2006;118(3 Suppl):92S-107S. [Crossref] [PubMed]