Congenital Anomalies of the Conjunctiva

oftalmoloji-17-2-kapak-wosonayiyok

Özlem CANDANa , Dicle HAZIROLANb

aUniversity of Health Sciences Faculty of Medicine, Ankara Health Application and Research Center, Department of Ophthalmology, Ankara, Türkiye
bUniversity of Health Sciences Faculty of Medicine, Haydarpaşa Numune Health Application and Research Center, Department of Ophthalmology, Ankara, Türkiye

ABSTRACT
The most common congenital anomalies of conjunctiva are nevus, limbal dermoids, hemangiomas and lymphangiomas. Conjunctival telangiectasia, which is less common, may be primary (hereditary) disorder or secondary manifestation of systemic diseases. Other anomalies include conjunctival dyskeratosis, osteoma, xerophthalmia, metabolic disorders affecting conjunctiva. Some types of congenital anomalies of the conjunctiva may remain asymptomatic, but others can cause disturbing symptoms or even lead to visual impairment. In addition, they may be the first sign of a systemic disease. Therefore, it is important to identify them early and treat them, if necessary.
Keywords: Conjunctiva; congenital; anomalies

Referanslar

  1. Pe'er J, Zajicek G, Greifner H, Kogan M. Streaming conjunctiva. Anat Rec. 1996;245(1):36-40. [Crossref]
  2. Khurana AK, Khurana I. Anatomy and Physiology of Eye (Modern System of Ophthalmology (MSO) Series). 3rd ed. India: CBS Publishers & Distributors Pvt. Ltd; 2017. p.1408-20.
  3. Jakobiec FA, Iwamoto T. Ocular adnexa: introduction to lids, conjunctiva, and orbit. In: Tasman W, Jaeger EA, eds. Duane's Foundations of Clinical Ophthalmology, vol 1. Philadelphia: Lippincott; 1994.
  4. Remington LA. Ocular adnexa and lacrimal system. In: Clinical Anatomy and Physiology of the Visual System. 3rd ed. Butterworth-Heinemann; Elsevier; 2012. p.168-170. [Crossref]
  5. Shields JA, Mashayekhi A, Kligman BE, Kunz WB, Criss J, Eagle RC Jr, et al. Vascular tumors of the conjunctiva in 140 cases. Ophthalmology. 2011; 118(9):1747-53. [Crossref]  [PubMed]
  6. Castillo BV Jr, Kaufman L. Pediatric tumors of the eye and orbit. Pediatr Clin North Am. 2003;50(1):149-72. [Crossref]  [PubMed]
  7. Jakobiec FA, Werdich XQ, Chodosh J, Freitag SK. An analysis of conjunctival and periocular venous malformations: clinicopathologic and immunohistochemical features with a comparison of racemose and cirsoid lesions. Surv Ophthalmol. 2014;59(2):236-44. [Crossref]  [PubMed]
  8. Nassiri N, Rootman J, Rootman DB, Goldberg RA. Orbital lymphaticovenous malformations: Current and future treatments. Surv Ophthalmol. 2015;60(5):383-405. [Crossref]  [PubMed]
  9. Awdry P. Lymphangiectasia haemorrhagica conjunctivae. Br J Ophthalmol. 1969;53(4):274-8. [Crossref]  [PubMed]  [PMC]
  10. Welch J, Srinivasan S, Lyall D, Roberts F. Conjunctival lymphangiectasia: a report of 11 cases and review of literature. Surv Ophthalmol. 2012;57(2):136-48. [Crossref]  [PubMed]
  11. Perry HD, Cossari AJ. Chronic lymphangiectasis in Turner's syndrome. Br J Ophthalmol. 1986;70(5):396-9. [Crossref]  [PubMed]  [PMC]
  12. Ramasubramanian A, Shields CL, Palamar M, Rousta ST, Shields JA. Conjunctival edema and distichiasis in association with congenital lymphedema of the lower legs. Ophthalmic Plast Reconstr Surg. 2009;25(2):148-50. [Crossref]  [PubMed]
  13. Tan JC, Mann S, Coroneo MT. Successful Treatment of Conjunctival Lymphangiectasia With Subconjunctival Injection of Bevacizumab. Cornea. 2016;35(10):1375-7. [Crossref]  [PubMed]
  14. Seca M, Borges P, Reimão P, Gomes M, Meireles A. Conjunctival lymphangioma: a case report and brief review of the literature. Case Rep Ophthalmol Med. 2012;2012:836573. [Crossref]  [PubMed]  [PMC]
  15. Ferreira MG, Nascimento FA, Teive HAG. Cerebellar Ataxia and Ocular Conjunctival Telangiectasia: Look Again. Neurology: Clinical Practice. 2021;11(4):e587-e8. [Crossref]  [PubMed]  [PMC]
  16. Goldberg SH, Bullock JD. Hereditary hemorrhagic telangiectasia. Ophthalmic Plast Reconstr Surg. 1990;6(2):136-8. [Crossref]  [PubMed]
  17. Knox FA, Frazer DG. Ophthalmic presentation of hereditary haemorrhagic telangiectasia. Eye. 2004;18(9):947-9. [Crossref]  [PubMed]
  18. Sahn EE, Hussey RH 3rd, Christmann LM. A case of Bloom syndrome with conjunctival telangiectasia. Pediatr Dermatol. 1997;14(2):120-4. [Crossref]  [PubMed]
  19. Knöpfel N, Martín-Santiago A, Saus C, Escudero-Góngora MM, Del Pozo LJ, Gómez C. Extensive Acquired Telangiectasias: Comparison of Generalized Essential Telangiectasia and Cutaneous Collagenous Vasculopathy. Actas Dermosifiliogr. 2017;108(3):e21-e6. English, Spanish. [Crossref]  [PubMed]
  20. Schelini MC, Chaves LFOB, Toledo MC, Rodrigues FW, de Oliveira T, Isaac DLC, et al. Xeroderma Pigmentosum: Ocular Findings in an Isolated Brazilian Group with an Identified Genetic Cluster. J Ophthalmol. 2019; 2019:4818162. [Crossref]  [PubMed]  [PMC]
  21. Rothstein K, Gálvez JM, Gutiérrez ÁM, Rico L, Criollo E, De-la-Torre A. Ocular findings in Fabry disease in Colombian patients. biomedica. 2019;39(3):434-9. [Crossref]  [PubMed]  [PMC]
  22. Decock C, De Laey JJ, Leroy BP, Kestelyn PH. Alport syndrome and conjunctival telangiectasia. Bull Soc Belge Ophtalmol. 2003;(290):29-31.
  23. Swann PG, Kwong E. The naevus of Ota. Clin Exp Optom. 2010;93(4):264-7. [Crossref]  [PubMed]
  24. Dutton JJ, Anderson RL, Schelper RL, Purcell JJ, Tse DT. Orbital malignant melanoma and oculodermal melanocytosis: report of two cases and review of the literature. Ophthalmology. 1984;91(5):497-507. [Crossref]  [PubMed]
  25. Eagle RC. Eye Pathology: An Atlas and Text. 2nd ed. Philadelphia: Lippincott Williams and Wilkins; 2011. p. 251.
  26. Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA. Conjunctival nevi: clinical features and natural course in 410 consecutive patients. Arch Ophthalmol. 2004;122(2):167-75. Erratum in: Arch Ophthalmol. 2006;124(2):198. Fasiudden, Airey [corrected to Fasiuddin, Airaj F]. [Crossref]  [PubMed]
  27. Tsilou E, Zhou M, Gahl W, Sieving PC, Chan CC. Ophthalmic manifestations and histopathology of infantile nephropathic cystinosis: report of a case and review of the literature. Surv Ophthalmol. 2007;52(1):97-105. [Crossref]  [PubMed]  [PMC]
  28. Grossniklaus HE, Green WR, Luckenbach M, Chan CC. Conjunctival lesions in adults. A clinical and histopathologic review. Cornea. 1987;6(2):78-116. [Crossref]  [PubMed]
  29. Demirci H, Shields CL, Eagle RC Jr, Shields JA. Conjunctival amyloidosis: report of six cases and review of the literature. Surv Ophthalmol. 2006; 51(4):419-33. [Crossref]  [PubMed]
  30. Feder RS, Berdy GJ, luorna JD, Markovich AL, Mian SI, Reilly CD, et al. Basic and Clinical Science Course, Section 08: External Disease and Cornea. AAO, 2022-2023. American Academy of Ophthalmology; 2022.
  31. Chévez Barrios P, Font RL. Pigmented conjunctival lesions as initial manifestation of ochronosis. Arch Ophthalmol. 2004;122(7):1060-3. [Crossref]  [PubMed]
  32. Okutucu M, Aslan MG, Findik H, Yavuz G. Glaucoma With Alkaptonuria as a Result of Pigment Accumulation. J Glaucoma. 2019;28(7):e112-e4. [Crossref]  [PubMed]
  33. Xin M, Gong YR, Jiang SH, Dai CH, Li SX, Shi WY. Preoperative evaluation and outcome of corneal transplantation for limbal dermoids: a ten-year follow-up study. Int J Ophthalmol. 2016;9(12):1756-60. [Crossref]
  34. Bhallil S, Benatiya I, El Abdouni O, Mahjoubi B, Hicham T. Goldenhar syndrome: ocular features. Bull Soc Belge Ophtalmol. 2010;(316):17-9.
  35. Vachette M, Moulin A, Zografos L, Schalenbourg A. Epibulbar osseous choristoma: a clinicopathological case series and review of the literature. Klin Monbl Augenheilkd. 2012;229(4):420-3. [Crossref]  [PubMed]
  36. von Sallmann L, Paton D. Hereditary Dyskeratosis of the Perilimbal Conjunctiva. Trans Am Ophthalmol Soc. 1959;57:53-62.
  37. Bui T, Young JW, Frausto RF, Markello TC, Glasgow BJ, Aldave AJ. Hereditary Benign Intraepithelial Dyskeratosis: Report of a Case and Re-examination of the Evidence for Locus Heterogeneity. Ophthalmic Genet. 2016;37(1):76-80. [Crossref]  [PubMed]  [PMC]
  38. Sommer A. Vitamin a deficiency and clinical disease: an historical overview. J Nutr. 2008;138(10):1835-9. [Crossref]  [PubMed]
  39. Gilbert C. The eye signs of vitamin A deficiency. Community Eye Health. 2013;26(84):66-7.
  40. Lee DA, Su WP, Liesegang TJ. Ophthalmic changes of Degos' disease (malignant atrophic papulosis). Ophthalmology. 1984;91(3):295-9. [Crossref]  [PubMed]
  41. Gunenç U, Kocak N. Genetics of Conjunctiva and Congenital Anomalies. Turkiye Klinikleri J Ophthalmol-Special Topics. 2008;1(3):83-7.