Diabetes Mellitus in Laboratory Animals

veterinerbilichastaliklari10-3-24kapak

Mehmet Çağrı KARAKURUMa , Işınsu AYTOPa
aBurdur Mehmet Akif Ersoy University Faculty of Veterinary Medicine, Department of Internal Medicine, Burdur, Türkiye

ABSTRACT
Diabetes mellitus is a major health problem with a high prevalence worldwide. Animal models have contributed greatly to the study of diabetes mellitus, an endocrine disease characterized by abnormal glucose homeostasis due to deficiencies in insulin secretion or action. It offers researchers the opportunity to control in vivo the genetic and environmental factors that may influence the development of the disease and the occurrence of its complications. Continuing such studies in spontaneously diabetic animals will help to better understand the etiology, pathogenesis and treatment. This chapter focuses on spontaneous diabetes and treatment options reported in laboratory animals such as ferrets, hamsters, chinchillas, guinea pigs and rabbits.

Keywords: Diabetes; laboratory animals; insulin; spontaneous

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