Diabetic Ketoasidosis

aciltip-10-2-kapak-wos

Sema KAYAa , Mehmet YILMAZa

aAnkara Bilkent City Hospital, Clinic of Emergency Medicine, Ankara, Türkiye

ABSTRACT
Diabetes mellitus is a disease caused by chronic hyperglycemia. DKA is the most common hyperglycemic emergency in patients with diabetes mellitus. There are tree findings in DKA: blood glucose level >250 milligram/dL (13.9 mmol/L), anion gap metabolic acidosis (pH 3.0mmol/L), bicarbonate level 10-12 mEq/L). Recognition of this condition is of utmost importance, because even small delays can have an impact on survival. Successful treatment of DKA requires frequent monitoring of patients, correction of hypovolemia and hyperglycemia, replacement of electrolyte losses, and careful search for the precipitating cause.
Keywords: Diabetic ketoacidosis; ketosis

Referanslar

  1. Perina D, Woods WA. Ketoacidotic Syndromes. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, et al., eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. McGraw-Hill Education; 2021. p. 1441-3.
  2. Nyce A, Byrne R, Lubkin CL, Chansky ME. Diabetic Ketoacidosis. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, et al., eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. McGraw-Hill Education; 2021. p.1433-41.
  3. Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015;6(6):850-67. [Crossref]  [PubMed]  [PMC]
  4. Umpierrez G, Korytkowski M. Diabetic emergencies - ketoacidosis, hyper- glycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol. 2016;12(4):222-32. [Crossref]  [PubMed]
  5. Smith RJ. Diabetes Mellitus, Hypoglycemia. In: Benjamim IJ, Griggs RJ, Wing EJ, Fitz JG, eds. Andreoli and Carpenter's Cecil Essential of Medicine. 9th ed. (Turkish). 2016. p. 668.
  6. Bratton SL, Krane EJ. Diabetic Ketoacidosis: Pathophysiology, Management and Complications. J Intensive Care Med. 1992;7(4):199-211. [Crossref]
  7. Glaser N, Kuppermann N. Pediatric Emergency Medicine, 2008.
  8. TEMD Diabetes Mellitus and Complications Diagnosis, Treatment and Mon- itoring Guide 2018. Acute Complications in Diabetes. 2018;119:126-8.
  9. Graffeo CS. Hyperosmolar Hyperglycemic State. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, et al.,eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. McGraw-Hill Education; 2021. p.1443-7.
  10. Dhatariya KK, Glaser NS, Codner E, Umpierrez GE. Diabetic ketoacidosis. Nat Rev Dis Primers. 2020;6(1):40. [Crossref]  [PubMed]
  11. Long B, Lentz S, Koyfman A, Gottlieb M. Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management. Am J Emerg Med. 2021;44:157-60. [Crossref]  [PubMed]
  12. Kahn CR, Weir G, King G, Joçobson A, Moses A, Smith R. Çev.ed.: Yumuk V. Diyabetik Ketoasidoz ve Hiperozmolar Hiperglisemik Durum. Joslin'S Diabetes Mellitus. İstanbul: Medikal Yayıncılık; 2008. p.647-52.
  13. Dorney K, Agus MSD. Endocrine Emergencies. Fleisher & Ludwig's Textbook of Pediatric Emergency Medicine; 2020. p.1610-23.
  14. Lee MH, Calder GL, Santamaria JD, MacIsaac RJ. Diabetic ketoacidosis in adult patients: an audit of factors influencing time to normalisation of meta- bolic parameters. Intern Med J. 2018;48(5):529-34. [Crossref]  [PubMed]
  15. Gosmanov AE, Gosmanova E, Kitabchi AE. Hyperglycemic Crises: Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar State (HHS). Endo- text. 2018.
  16. Umpierrez GE, Kelly JP, Navarrete JE, Casals MM, Kitabchi AE. Hyperglycemic crises in urban blacks. Arch Intern Med. 1997;157(6):669-75. [Crossref]  [PubMed]
  17. Fayfman M, Pasquel FJ, Umpierrez GE. Management of Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. Med Clin North Am. 2017;101(3):587-606. [Crossref]  [PubMed]  [PMC]
  18. Rosenbloom AL, Hanas R. Diabetic ketoacidosis (DKA): treatment guidelines. Clin Pediatr (Phila). 1996;35(5):261-6. [Crossref]  [PubMed]