Diş Çürüğünün Biyokimyası

oral-biyokimya

Deniz Yanık

Bu bölüm çürük oluşumuna, etyopatogenzine, çürük oluşumunu kolaylaştıran faktörlere, demineralizasyon ve remineralizasyon dengesine, biyofilmin biyokimyasına odaklanmıştır. Çürük oluşumunu, mine ve dentindeki ilerleyiş farklılıkları ve pulpada oluşturduğu değişiklikler kapsamında açıklamaktadır. Tüm bu süreçlerin öncesinde de sağlıklı mine ve dentinin biyokimyasal yapısını, organik ve inorganik bileşenlerini, özelliklerini ve fonksiyonlarını açıklamaktadır. Çürük, geniş kitleleri ilgilendiren yaygın bir halk sağlığı problemidir ve diş hekimliği kliniğindeki en yüksek prevlansa sahip kronik hastalıklardan biridir. Çürük etyopatogenezi pek çok biyolojik faktörden etkilendiği gibi sosyoekonomik seviye ile de yakın temas içindedir. Ne yazık ki bu hastalık, fizyolojik olarak rejenerasyon kapasitesine sahip olmayan bir doku olan mineyi yıkarak ilerler. Daha da kötüsü herhangi bir tedavi ya da ilaç, kayıp mine dokusunu yerine koyamaz, klinik tedaviler sadece kayıp dokunun yapay materyallerle restore edilmesini içerir. Bu yüzden çürüğün etkilediği diş dokularının biyokimyasal yapısını ve metabolizmalarını bilmek, koruyucu önlemlerin ve ilgili ajanların geliştirilmesi için yönlendirici olacaktır.

Diş Çürüğünün Biyokimyası bölümü ayrıca, minenin ve dentin-pulpa kompleksinin rejenerasyonu için gelecekteki klinik uygulamalara ve tedavilere temel oluşturabilecek biyokimyasal açıdan zengin bilimsel bilginin önemini vurgular.

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