FROM NEUROSCIENCE LABORATORY TO NEUROLOGY CLINIC

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EEG MICROSTATE ANALYSIS: CLINICAL APPLICATIONS AND INTERPRETATIONS

Eren Toplutaş

İstanbul Medipol University, Faculty of Medicine, Department of Neurology, İstanbul, Türkiye

Toplutaş E. EEG Microstate Analysis: Clinical Applications and Interpretations. In: Hanoğlu L, editor. From Neuroscience Laboratory to Neurology Clinic. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.3339

ABSTRACT

Various analytical methods are employed to derive insights from electroencephalography (EEG) signals, among which microstate analysis is particularly notable. This approach conceptualizes multichannel EEG recordings as sequences of quasistable microstates, each defined by a distinct topography of electrical potentials across the entire array of channels. By concurrently evaluating signals from all cortical regions, microstate analysis facilitates the assessment of largescale brain networks, whose disruptions are linked to a range of neuropsychiatric disorders. Restingstate microstates have shown significant alterations in various neuropsychiatric and behavioral conditions, highlighting their potential as a diagnostic tool for identifying neurophysiological disturbances and monitoring changes following therapeutic interventions. These microstate sequences represent the rapid transitions between neural networks during resting states, potentially overlapping with the activity of restingstate networks identified by other neuroimaging modalities. As such, microstate analysis emerges as a promising neurophysiological method for investigating and evaluating brain network dynamics with millisecondlevel temporal resolution.

Keywords: Electroencephalography; EEG, microstate analyses

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