ENDOCRINE PHYSIOLOGY
Adem Yalçınkaya
Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Department of Anesthesiology and Reanimation, Ankara, Türkiye
Yalçınkaya E. Endocrine Physiology. In: Kazancı D, editor. Anesthesiology Fast Review. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.65-78.
ABSTRACT
- The endocrine system operates in conjunction with the neurological and immunological systems, representing the most extensive message system throughout the body.
- The endocrine system comprises three fundamental components; endocrine glands, hormones, target organs. Hormonal receptors convey hormonal messages into the cell through several pathways.
- The hypothalamic-pituitary-adrenal (HPA) axis links the hypothalamus and anterior pituitary, regulating various hormones.
- The hypothalamus secretes hormones such as corticotropin-releasing hormone, thyrotropin-releasing hormone, gonadotropin-releasing hormone, growth hormone-releasing hormone, somatostatin, prolactin-releasing hormone, and dopamine.
- The neurohypophysis comprises three components: the supraoptic and paraventricular nuclei of the hypothalamus, the supraoptic-pituitary tract, and the posterior pituitary.
- Thyroid hormones are crucial throughout an individual’s lifespan, regulating the metabolic activity and function of nearly all organs.
- PTH is the principal regulator of calcium and phosphate equilibrium in the human body. Insulin primarily functions to regulate glucose levels. It is a potent modulator of metabolic processes.
- Glucagon purpose is to elevate glucose levels in the body.
- Adrenal glands synthesizes hormones including aldosterone, cortisol, DHEA, norepinephrine, and epinephrine.
Keywords: Endocrine system; Hormones; Endocrine glands; Hypothalamic-pituitary-gonadal axis; Homeostasis
×
Kaynak Göster
Referanslar
- Imamoglu S. Endokrin Sistem ve Hormonlarin Fizyolojileri. In: Imamoglu S, Ozyardimci Ersoy C, eds. Gecmisten Gelecege Endokrinoloji. Vol 1. 1st ed. Bayt; 2019:3-26. [Link]
- Brook CMN. The Endocrine System. In: Brook C, Marshall N, eds. The Endocrine System. Vol 1. 3. Black Well Science; 1996. [Link]
- Kronenberg HM, Melmed S, Larsen PR. Williams Textbook of Endocrinology. In: Kronenberg HM, Melmed S, Larsen PR, eds. Vol 1. 11th ed. WB Saunders; 2008:3-12. [Link]
- JL Jameson. Principles of Endocrinology. Endocrinology: Adult and Pediatric. 2016;1-2:3-15.e1. [Crossref] [PMC]
- Kono T, Barham FW. The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells. J Biol Chem. 1971;25(246). [Crossref] [PubMed]
- J González-Maeso, SC Sealfon, Hormone Signaling Via G Protein-Coupled Receptors, Endocrinology: Adult and Pediatric, Sixth Edition. 2010;1:83-105, doi: 10.1016/B978-1-4160-5583-9.00005-8. [Crossref]
- Katritch V, Cherezov V, Stevens RC. Structure-Function of the G Protein-Coupled Receptor Superfamily. Annu Rev Pharmacol Toxicol. 2013;53(1):531-556. [Crossref] [PubMed] [PMC]
- Gilman AG. G Proteins: Transducers Of Receptor-Generated Signals. Annu Rev Biochem. 1987;56(1):615-649. [Crossref] [PubMed]
- Webb P, Baxter J. Introduction to Endocrinology . In: Gardner D, Shoback D, eds. Greenspan's Basic and Clinical Endocrinology. 8, 2007:2-33. [Link]
- Cidlowski JA, Malchoff CD, Malchoff DM. Glucocorticoid Receptors, Their Mechanisms of Action, and Glucocorticoid Resistance, Endocrinology: Adult and Pediatric. 2016;2-2:1717-1726.e4. [Crossref]
- Christ-Crain M, Ball S. The Neurohypophysis: Endocrinology of Vasopressin and Oxytocin. Endotext. Published online November 9, 2022. Accessed January 28, 2025. [Link]
- Goldsmith SR. Vasopressin as vasopressor. Am J Med. 1987;82(6):1213-1219. [Crossref] [PubMed]
- Baylis PH. Osmoregulation and control of vasopressin secretion in healthy humans. Am J Physiol. 1987;253(5 Pt 2). [Crossref] [PubMed]
- Dunn FL, Brennan TJ, Nelson AE, Robertson GL. The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest. 1973;52(12):3212-3219. [Crossref] [PubMed] [PMC]
- Johnstone C, Hendry C, Farley A, McLafferty E. Endocrine system: part 1. Nurs Stand. 2014;28(38):42-49. [Crossref]
- Pimstone B, Epstein S, Hamilton SM, Leroith D, Hendricks S. Metabolic clearance and plasma half disappearance time of exogenous gonadotropin releasing hormone in normal subjects and in patients with liver disease and chronic renal failure. J Clin Endocrinol Metab. 1977;44(2):356-360. [Crossref] [PubMed]
- Skynner MJ, Sim JA, Herbison AE. Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neurons. Endocrinology. 1999;140(11):5195-5201. [Crossref] [PubMed]
- Roy D, Angelini NL, Belsham DD. Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology. 1999;140(11):5045-5053. [Crossref] [PubMed]
- Nieman LK, Cutler GB, Oldfield EH, Loriaux DL, Chrousos GP. The ovine corticotropin-releasing hormone (CRH) stimulation test is superior to the human CRH stimulation test for the diagnosis of Cushing's disease. J Clin Endocrinol Metab. 1989;69(1):165-169. [Crossref] [PubMed]
- Lamberts SWJ, van der Lely AJ, de Herder WW, Hofland LJ. Octreotide. Wood AJJ, ed. N Engl J Med. 1996;334(4):246-254. [Crossref] [PubMed]
- Stengel A, Taché Y. Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications. Front Endocrinol (Lausanne). 2013;3(JAN). [Crossref] [PubMed] [PMC]
- Gonzaga M de F de M, de Castro LF, Naves LA, et al. Prolactinomas Resistant to Treatment With Dopamine Agonists: Long-Term Follow-Up of Six Cases. Front Endocrinol (Lausanne). 2018;9. [Crossref] [PubMed] [PMC]
- Jackson IMD. Thyrotropin-releasing hormone. N Engl J Med. 1982;306(3):145-155. [Crossref] [PubMed]
- Wu P, Lechan RM, Jackson IMD. Identification and characterization of thyrotropin-releasing hormone precursor peptides in rat brain. Endocrinology. 1987;121(1):108-115. [Crossref] [PubMed]
- Honbo KS, Van Herle AJ, Kellett KA. Serum prolactin levels in untreated primary hypothyroidism. Am J Med. 1978;64(5):782-787. [Crossref] [PubMed]
- Snyder PJ, Jacobs LS, Utiger RD, Daughaday WH. Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone. J Clin Invest. 1973;52(9):2324-2329. [Crossref] [PubMed] [PMC]
- Mendoza A, Hollenberg AN. New insights into thyroid hormone action. Pharmacol Ther. 2017;173:135-145. [Crossref] [PubMed] [PMC]
- Bilezikian JP, Loeb JN. The influence of hyperthyroidism and hypothyroidism on alpha- and beta-adrenergic receptor systems and adrenergic responsiveness. Endocr Rev. 1983;4(4):378-388. [Crossref] [PubMed]
- Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122(9):3035-3043. [Crossref] [PubMed] [PMC]
- Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006;116(10):2571-2579. [Crossref] [PubMed] [PMC]
- Ho Y, Liebhaber SA, Cooke NE. Activation of the human GH gene cluster: Roles for targeted chromatin modification. Trends in Endocrinology and Metabolism. 2004;15(1):40-45. [Crossref] [PubMed]
- Brooks AJ, Waters MJ. The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol. 2010;6(9):515-525. [Crossref] [PubMed]
- Leung KC, Waters MJ, Markus I, Baumbach WR, Ho KKY. Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: a novel mechanism of growth hormone receptor regulation. Proc Natl Acad Sci U S A. 1997;94(21):11381-11386. [Crossref] [PubMed] [PMC]
- Dickstein G, Shechner C, Nicholson WE, et al. Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab. 1991;72(4):773-778. [Crossref] [PubMed]
- Crowley S, Hindmarsh PC, Holownia P, Honour JW, Brook CGD. The use of low doses of ACTH in the investigation of adrenal function in man. J Endocrinol. 1991;130(3):475-479. [Crossref] [PubMed]
- Van Herle AJ, Vassart G, Dumont JE. Control of thyroglobulin synthesis and secretion. (First of two parts). N Engl J Med. 1979;301(5):239-249. [Crossref] [PubMed]
- Hall JE, Hall ME. Parathyroid Hormone, Calcitonin, Calcium and Phosphate Metabolism, Vitamin D, Bone, and Teeth. In: Hall JE, Hall ME, eds. Guyton and Hall Textbook of Medical Physiology. 14. Elsevier; 2021:991-1009. [Link]
- D'Amour P, Räkel A, Brossard JH, Rousseau L, Albert C, Cantor T. Acute regulation of circulating parathyroid hormone (PTH) molecular forms by calcium: utility of PTH fragments/PTH(1-84) ratios derived from three generations of PTH assays. J Clin Endocrinol Metab. 2006;91(1):283-289. [Crossref] [PubMed]
- Brown EM, Pollak M, Seidman CE, et al. Calcium-ion-sensing cell-surface receptors. N Engl J Med. 1995;333(4):234-240. [Crossref] [PubMed]
- Brown EM. Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab. 1983;56(3):572-581. [Crossref] [PubMed]
- Kahn BB. Lilly lecture 1995. Glucose transport: pivotal step in insulin action. Diabetes. 1996;45(11):1644-1654. [Crossref] [PubMed]
- STRÅLFORS P, HONNOR RC. Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity. Eur J Biochem. 1989;182(2):379-385. [Crossref] [PubMed]
- Keller U, Lustenberger M, Stauffacher W. Effect of insulin on ketone body clearance studied by a ketone body "clamp" technique in normal man. Diabetologia. 1988;31(1):24-29. [Crossref] [PubMed]
- Banskota NK, Taub R, Zellner K, King GL. Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Mol Endocrinol. 1989;3(8):1183-1190. [Crossref] [PubMed]
- Raju B, Cryer PE. Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. Diabetes. 2005;54(3):757-764. [Crossref] [PubMed]
- Gosmanov NR, Szoke E, Israelian Z, et al. Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. Diabetes Care. 2005;28(5):1124-1131. [Crossref] [PubMed]
- Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017;125(Pt A):21-38. [Crossref] [PubMed] [PMC]
- Miller WL. Molecular Biology of Steroid Hormone Synthesis*. Endocr Rev. 1988;9(3):295-318. [Crossref] [PubMed]
- Smith SR, Bledsoe T, Chhetri MK. Cortisol metabolism and the pituitary-adrenal axis in adults with protein-calorie malnutrition. J Clin Endocrinol Metab. 1975;40(1):43-52. [Crossref] [PubMed]
- Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 1984;59(3):551-555. [Crossref] [PubMed]
- Ahlquist Rp. A Study of the Adrenotropic Receptors. Am J Physiol. 1948;153(3):586-600. [Crossref] [PubMed]
- Müllner M, Urbanek B, Havel C, Losert H, Gamper G, Herkner H. Vasopressors for shock. Cochrane Database Syst Rev. 2004;(3). [Crossref]
- Allwood MJ, Cobbold AF, Ginsburg J. Peripheral vascular effects of noradrenaline, isopropylnoradrenaline and dopamine. Br Med Bull. 1963;19(2):132-136. [Crossref] [PubMed]
- De Backer D, Creteur J, Silva E, Vincent JL. Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med. 2003;31(6):1659-1667. [Crossref] [PubMed]
- Moran JL, O'Fathartaigh MS, Peisach AR, Chapman MJ, Leppard P. Epinephrine as an inotropic agent in septic shock: a dose-profile analysis. Crit Care Med. 1993;21(1):70-77. [Crossref] [PubMed]
- Hollenberg SM, Ahrens TS, Astiz ME, et al. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med. 1999;27(3):639-660. [Crossref] [PubMed]
- Jost A. Hormonal factors in the sex differentiation of the mammalian foetus. Philos Trans R Soc Lond B Biol Sci. 1970;259(828):119-130. [Crossref] [PubMed]
- Filicori M, Santoro N, Merriam GR, Crowley WF. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab. 1986;62(6):1136-1144. [Crossref] [PubMed]
- Treloar A, Boynton R, Behn B. Variation of the human menstrual cycle through reproductive life. Int J Fertil. 1967;12(1):77-126. [PubMed]
- Adams JM, Taylor AE, Schoenfeld DA, Crowley WF, Hall JE. The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency. J Clin Endocrinol Metab. 1994;79(3):858-864. [Crossref] [PubMed]
- Taylor AE, Whitney H, Hall JE, Martin K, Crowley WF. Midcycle levels of sex steroids are sufficient to recreate the follicle-stimulating hormone but not the luteinizing hormone midcycle surge: evidence for the contribution of other ovarian factors to the surge in normal women. J Clin Endocrinol Metab. 1995;80(5):1541-1547. [Crossref] [PubMed]
- Martin KA, Welt CK, Taylor AE, Smith JA, Crowley WF, Hall JE. Is GnRH reduced at the midcycle surge in the human? Evidence from a GnRH-deficient model. Neuroendocrinology. 1998;67(6):363-369. [Crossref] [PubMed]
- Sherman BM, West JH, Korenman SG. The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab. 1976;42(4):629-636. [Crossref] [PubMed]
- Hewitt SC, Harrell JC, Korach KS. Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol. 2005;67:285-308. [Crossref] [PubMed]
- Heldring N, Pike A, Andersson S, et al. Estrogen receptors: how do they signal and what are their targets. Physiol Rev. 2007;87(3):905-931. [Crossref] [PubMed]
- Siiteri PK, Wilson JD. Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab. 1974;38(1):113-125. [Crossref] [PubMed]
- Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature. 1990;346(6281):240-244. [Crossref] [PubMed]
- De Zegher F, Francois I, Boehmer ALM, et al. Androgens and fetal growth. Horm Res. 1998;50(4):243-244. [Crossref] [PubMed]
- Blumenfeld Z. Investigational and experimental GnRH analogs and associated neurotransmitters. Expert Opin Investig Drugs. 2017;26(6):661-667. [Crossref] [PubMed]
- Winters SJ, Troen P. Testosterone and estradiol are co-secreted episodically by the human testis. J Clin Invest. 1986;78(4):870-873. [Crossref] [PubMed] [PMC]
- Ruwanpura SM, McLachlan RI, Meachem SJ. Hormonal regulation of male germ cell development. J Endocrinol. 2010;205(2):117-131. [Crossref] [PubMed]
- Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiol Rev. 2017;97(3):995-1043. [Crossref] [PubMed] [PMC]
- Finkelstein JS, Lee H, Burnett-Bowie SAM, et al. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013;369(11):1011-1022. [Crossref] [PubMed] [PMC]
- Finkelstein JS, Lee H, Leder BZ, et al. Gonadal steroid-dependent effects on bone turnover and bone mineral density in men. J Clin Invest. 2016;126(3):1114-1125. [Crossref] [PubMed] [PMC]