CHILDHOOD ANAPHYLAXIS: NEW DEVELOPMENTS IN DIAGNOSIS AND TREATMENT

CHILDHOOD_ANAPHYLAXIS_NEW_DEVELOPMENTS _IN_DIAGNOSIS_AND_TREATMENT_kapak

EXERCISE-INDUCED ANAPHYLAXIS

Sinem Aslan1 Muhammet Kaya2

1Eskişehir Osmangazi University, Faculty of Medicine, Department of Pediatric Immunology and Allergic Diseases, Eskişehir, Türkiye
2Eskişehir Osmangazi University, Faculty of Medicine, Department of Pediatric Immunology and Allergic Diseases, Eskişehir, Türkiye

Aslan S, Kaya M. Exercise-Induced Anaphylaxis. In: Harmancı K, editor. Childhood Anaphylaxis: New Developments in Diagnosis and Treatment. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.115-122.

ABSTRACT

Exercise-induced anaphylaxis (EIA) encompasses a heterogeneous group of anaphylactic conditions precipitated by physical exertion. Common clinical features include flushing, pruritus, urticaria, angioedema, respiratory symptoms (e.g., bronchospasm, dyspnea), gastrointestinal symptoms (such as nausea, vomiting, or abdominal cramps), hypotension, and syncope or collapse related to exercise. The most extensively studied and well-defined variant of EIA is food-dependent exercise-induced anaphylaxis (FDEIA), characterized by the onset of symptoms exclusively when physical activity is undertaken following the ingestion of specific allergenic foods. The frequency and predictability of symptoms vary considerably, and in some patients, manifestations occur only in the presence of cofactors. Although rare, EIA is a clinical entity that should be recognized by all healthcare professionals. The pathophysiological and immunological mechanisms underlying EIA remain largely unknown. Management primarily involves prescribing an epinephrine auto-injector, developing emergency action plans, and avoiding known triggers.

Keywords: Exercise-induced anaphylaxıs; Anaphlaxis

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