FROM NEUROSCIENCE LABORATORY TO NEUROLOGY CLINIC

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FROM STRUCTURE TO FUNCTION: BRAIN DRAINAGE SYSTEMS

Nagihan Mantar

İstanbul Medipol University, Vocational School of Health Services, Program of Electroneurophysiology, İstanbul, Türkiye

Mantar N. From Structure to Function: Brain Drainage Systems. In: Hanoğlu L, editor. From Neuroscience Laboratory to Neurology Clinic. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.173182.

ABSTRACT

This chapter focuses on the glymphatic system and meningeal lymphatics, which are essential for managing brain drainage. Recent studies underscore their pivotal role in central nervous system homeostasis and clearing metabolic byproducts. The brain is a metabolically active organ and utilizes different pathways to clear metabolic waste. The glymphatic system, a clearance pathway that relies on glial cells to remove soluble proteins and metabolic wastes from the cerebrospinal fluid, and its functionally connected meningeal lymphatics are regarded the major pathways for brain waste clearance. Both systems play an important role in brain homeostasis, and disruption of this maintenance has been associated with various neurological diseases. Therefore, we discuss the anatomical, functional, and clinical aspects of the glymphatic system and meningeal lymphatics concerning central nervous system waste removal mechanisms.

Keywords: Glymphatic system; Meningeal lymphatic vessels; Perivascular space; Cerebrospinal fluid; Neurological disorders

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