MICROBIOTA

microbiotakapak

GUT-BRAIN AXIS

Turay Mutlu1
Buğra Selluncak2
Büşra Nur Balıkel3
İsmet Murat Melek4

1Ankara Etlik City Hospital, Department of Neurology, Ankara, Türkiye
2Adana City Hospital, Department of Neurology, Adana, Türkiye
3Hatay Mustafa Kemal University, Faculty of Medicine, Department of Neurology, Hatay, Türkiye
4Ankara Etlik City Hospital, Department of Neurology, Ankara, Türkiye

Mutlu T, Selluncak B, Balıkel BN, Melek İM. Gut-Brain Axis. Melek İM, Aydoğan S, eds. Microbiota. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.11-22.

ABSTRACT

The gut microbiota is a rich ecosystem of trillions of microorganisms, including bacteria as well as fungi and viruses. Structural and functional changes in this integrated entity have various effects on the nervous system, both directly and through systemic interactions. The bidirectional communication between the gastrointestinal system and the nervous system, which are closely related, is defined as the “gut-brain axis”. The outcomes of the mechanisms defined within this axis can have either neuroprotective or pathological character. Strategies to be developed through these effects, which have been studied specifically for diseases, have the opportunity to offer prevention measures and treatment options. Therefore, the goal of expanding existing approaches necessitates an in-depth understanding of this mysterious field.

Keywords: Intestines; Enteric nervous system; Central nervous system; Vagus nerve; Inflammation

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