Immediate Contact Reactions: Pathomechanisms and Clinical Presentation

Hatice Gamze DEMİRDAĞa

aAcıbadem Ankara Hospital, Clinic of Dermatology, Ankara, Türkiye

Demirdağ HG. Immediate contact reactions: Pathomechanisms and clinical presentation. In: Günaştı Topal S, ed. Contact Dermatitis. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.8-13.

ABSTRACT

Immediate contact reactions comprise allergic and nonallergic inflammatory reactions of the skin or mucous membranes including contact urticaria, contact urticaria syndrome, and protein contact dermatitis. They frequently start within 30-60 min following skin exposure of causative agent and clear completely within 24 h. However, delayed onset reactions may occur within 4-6 h. Type I hypersensitivity reactions or non-immunological mechanisms play a role in pathogenesis. In dermatology practice, immediate contact reactions are common but are frequently underdiagnosed and/or misdiagnosed.

Keywords: Dermatitis, contact; urticaria; hypersensitivity, immediate; immunologic factors

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