Immunotherapy for Endometrial Carcinoma

tibbionko-17-1-kapak

Pınar KUBİLAY TOLUNAYa , Cengiz KARAÇİNa
aDr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Medical Oncology, Ankara, Türkiye

Kubilay Tolunay P, Karaçin C. Immunotherapy for endometrial carcinoma. In: Şendur MAN, ed. Current Immunotherapy Landscape for Solid Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.119-23.

ABSTRACT
Endometrial cancer is a common and fatal malignancy in women. While early-stage disease often has favorable outcomes, recurrent or metastatic endometrial cancer is challenging to treat with limited treatment options and poor survival rates. Immune checkpoint inhibitors and tyrosine kinase inhibitors are emerging therapeutic approaches for recurrent or metastatic endometrial cancer. The Cancer Genome Atlas (TCGA) has provided insights into the role of different immunotherapeutic approaches based on molecular subtypes of endometrial cancer. Immune checkpoint inhibitors have shown promise in recurrent or metastatic endometrial cancer, particularly in tumors with microsatellite instability. However, strategies to enhance response or overcome resistance to immune checkpoint inhibitors for endometrial cancer. Immunotherapy holds promise for the treatment of endometrial cancer, particularly when tailored to specific molecular subtypes and combined with other therapeutic approaches.

Keywords: Endometrial cancer; immunotherapy; immune checkpoint inhibitors

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