Inappropriate Antidiuretic Hormone Syndrome

aciltip-10-2-kapak-wos

Nurullah AKTAŞa , Ahmet Emre AYb

aAnkara Bilkent City Hospital, Clinic of Emergency Medicine, Ankara, Türkiye
bEtimesgut Şehit Sait Ertürk State Hospital, Clinic of Emergency Medicine, Ankara, Türkiye

ABSTRACT

Inappropriate ADH (antidiuretic hormone) syndrome is an endocrine emergency with hyponatremia, low serum and high urine osmolarity. Although there are many underlying etiological factors, central nervous system pathologies, drugs and especially small cell lung carcinoma should be kept in mind. Despite the increase in ADH level, euvolemia is observed in patients because systems that balance osmolarity such as RAA (renin-angiotensin-aldosterone) and ANP (atrial natriuretic peptide) are intact. Determination and management of the underlying cause is essential in the treatment process. However, serum sodium level and the development time of hyponatremia are also substantial in guiding the treatment process.”Central pontine demyelinosis”, which we may encounter with the rapid correction of hyponatremia, is a complication that should be kept in mind.
Keywords: Antidiuretic; vasopressin; hyponatremia; inappropriate ADH syndrome; arginine vasopressin; hyponatremia

Referanslar

  1. Chen S, Shieh M, Chiaramonte R, Shey J. Improving on the Adrogué-Madias Formula. Kidney360. 2020;2(2):365-70. [Crossref]  [PubMed]  [PMC]
  2. Rose BD, Post TW. Clinical Physiology of Acid-Base and Electrolyte Disorders. 5th ed. New York: McGraw-Hill; 2001. p.703.
  3. Bartter FC, Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967;42(5):790-806. [Crossref]  [PubMed]
  4. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med. 2007;356(20):2064-72. [Crossref]  [PubMed]
  5. ten Holt WL, van Iperen CE, Schrijver G, Bartelink AK. Severe hyponatremia during therapy with fluoxetine. Arch Intern Med. 1996;156(6):681-2. [Crossref]  [PubMed]
  6. Holden R, Jackson MA. Near-fatal hyponatraemic coma due to vasopressin over-secretion after "ecstasy" (3,4-MDMA). Lancet. 1996;347(9007):1052. [Crossref]  [PubMed]
  7. Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. Am J Kidney Dis. 2008;52(1):144-53. [Crossref]  [PubMed]
  8. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, et al. Diabetes insipidus. Nat Rev Dis Primers. 2019;5(1):54. [Crossref]  [PubMed]
  9. Verbalis JG. Pathogenesis of hyponatremia in an experimental model of the syndrome of inappropriate antidiuresis. Am J Physiol. 1994;267(6 Pt 2):R1617-25. [Crossref]  [PubMed]
  10. Robertson GL. Regulation of arginine vasopressin in the syndrome of inappropriate antidiuresis. Am J Med. 2006;119(7 Suppl 1):S36-42. [Crossref]  [PubMed]
  11. Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M, et al. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. J Am Soc Nephrol. 2014;25(10):2376-83. [Crossref]  [PubMed]  [PMC]
  12. DeFronzo RA, Goldberg M, Agus ZS. Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1976;84(5):538-42. [Crossref]  [PubMed]
  13. Verbalis JG, Greenberg A, Burst V, Haymann JP, Johannsson G, Peri A, et al. Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion. Am J Med. 2016;129(5):537.e9-537.e23. [Crossref]  [PubMed]
  14. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, et al; Hyponatraemia Guideline Development Group. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol. 2014;170(3):G1-47. Erratum in: Eur J Endocrinol. 2014;171(1):X1. [Crossref]  [PubMed]
  15. Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999;106(4):399-403. [Crossref]  [PubMed]
  16. Shannon G. Severe hyponatraemia - recognition and management. Aust Presc. 2011;34:42-5. [Crossref]
  17. Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, et al. Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med. 2013;126(10 Suppl 1):S1-42. [Crossref]  [PubMed]
  18. Rondon-Berrios H, Sterns RH. Hypertonic Saline for Hyponatremia: Meeting Goals and Avoiding Harm. Am J Kidney Dis. 2022;79(6):890-6. [Crossref]  [PubMed]  [PMC]
  19. Sterns RH, Rondon-Berrios H, Adrogué HJ, Berl T, Burst V, Cohen DM, et al; PRONATREOUS Investigators. Treatment Guidelines for Hyponatremia: Stay the Course. Clin J Am Soc Nephrol. 2023 Jun 28. [Crossref]  [PubMed]
  20. Warren AM, Grossmann M, Christ-Crain M, Russell N. Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management. Endocr Rev. 2023;44(5):819-861. [Crossref]  [PubMed]  [PMC]
  21. Greenberg A, Verbalis JG. Vasopressin receptor antagonists. Kidney Int. 2006;69(12):2124-30. [Crossref]  [PubMed]
  22. Forrest JN Jr, Cox M, Hong C, Morrison G, Bia M, Singer I. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1978;298(4):173-7. [Crossref]  [PubMed]
  23. Grünfeld JP, Rossier BC. Lithium nephrotoxicity revisited. Nat Rev Nephrol. 2009;5(5):270-6. [Crossref]  [PubMed]