Inappropriate Antidiuretic Hormone Syndrome

Nurullah AKTAŞa , Ahmet Emre AYb

aAnkara Bilkent City Hospital, Clinic of Emergency Medicine, Ankara, Türkiye
bEtimesgut Şehit Sait Ertürk State Hospital, Clinic of Emergency Medicine, Ankara, Türkiye

ABSTRACT

Inappropriate ADH (antidiuretic hormone) syndrome is an endocrine emergency with hyponatremia, low serum and high urine osmolarity. Although there are many underlying etiological factors, central nervous system pathologies, drugs and especially small cell lung carcinoma should be kept in mind. Despite the increase in ADH level, euvolemia is observed in patients because systems that balance osmolarity such as RAA (renin-angiotensin-aldosterone) and ANP (atrial natriuretic peptide) are intact. Determination and management of the underlying cause is essential in the treatment process. However, serum sodium level and the development time of hyponatremia are also substantial in guiding the treatment process.”Central pontine demyelinosis”, which we may encounter with the rapid correction of hyponatremia, is a complication that should be kept in mind.
Keywords: Antidiuretic; vasopressin; hyponatremia; inappropriate ADH syndrome; arginine vasopressin; hyponatremia

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