CHILDHOOD ANAPHYLAXIS: NEW DEVELOPMENTS IN DIAGNOSIS AND TREATMENT

CHILDHOOD_ANAPHYLAXIS_NEW_DEVELOPMENTS _IN_DIAGNOSIS_AND_TREATMENT_kapak

INFANT ANAPHYLAXIS

Gizem Atakul

Private Physician, Department of Pediatric Immunology and Allergic Diseases, İstanbul, Türkiye

Atakul G. Infant Anaphylaxis. In: Harmancı K, editor. Childhood Anaphylaxis: New Developments in Diagnosis and Treatment. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.335-341.

ABSTRACT

Anaphylaxis is a life-threatening, acute-onset severe systemic reaction. Infantile anaphylaxis presents with distinct clinical manifestations compared to other age groups, which may lead to diagnostic challenges for clinicians and, in some cases, missed diagnoses. More information is needed to define the epidemiology, triggers, comorbidities, and cofactors specific to this group. Although epinephrine is the first-line treatment, epinephrine auto-injectors are not yet fully suitable for this age group. This section provides an overview of the diagnosis, triggers, and clinical management of infantile anaphylaxis.

Keywords: Anaphylaxis; Epinephrine; Allergy and immunology

Referanslar

  1. Cardona V, Ansotegui IJ, Ebisawa M, El-Gamal Y, Fernandez Rivas M, Fineman S, et al. World allergy organization anaphylaxis guidance, 2020. World Allergy Organ J. 2020;13(10):100472. [Crossref]  [PubMed]  [PMC]
  2. Muraro A, Worm M, Alviani C, Cardona V, DunnGalvin A, Garvey LH, et al. EAACI guidelines: Anaphylaxis (2021 update). Allergy. 2022;77(2):357-77. [Crossref]  [PubMed]
  3. Topal E, Bakirtas A, Yilmaz O, Ertoy Karagol IH, Arga M, Demirsoy MS, et al. Anaphylaxis in infancy compared with older children. Allergy Asthma Proc. 2013;34(3):233-8. [Crossref]  [PubMed]
  4. Carlisle A, Lieberman J. Clinical Management of Infant Anaphylaxis. J Asthma Allergy. 2021;8;14:821-827. [Crossref]  [PubMed]  [PMC]
  5. Greenhawt M, Gupta RS, Meadows JA, Pistiner M, Spergel JM, Camargo CA Jr, et al. Guiding principles for the recognition, diagnosis, and management of infants with anaphylaxis: An expert panel consensus. J Allergy Clin Immunol Pract. 2019;7(4):1148-56.e5. [Crossref]  [PubMed]
  6. Robinson LB, Arroyo AC, Faridi MK, Rudders S, Camargo CA Jr. Trends in US emergency department visits for anaphylaxis among infants and toddlers: 2006-2015. J Allergy Clin Immunol Pract. 2021;9(5):1931-38.e2. [Crossref]  [PubMed]  [PMC]
  7. De Filippo M, Votto M, Albini M, Castagnoli R, De Amici M, Marseglia A, et al. Pediatric anaphylaxis: A 20-year retrospective analysis. J Clin Med. 2022;7;11(18):5285. [Crossref]  [PubMed]  [PMC]
  8. Grabenhenrich LB, Dölle S, Moneret-Vautrin A, Köhli A, Lange L, Spindler T, et al. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J Allergy Clin Immunol. 2016;137(4):1128-1137.e1. [Crossref]  [PubMed]
  9. Samady W, Trainor JL, Smith BM, Gupta RS. Food-induced anaphylaxis in infants and children. Ann Allergy Asthma Immunol. 2018;121(3):360-5. [Crossref]  [PubMed]
  10. Chiampou E, Douros K, Moriki D, Marina M, Anastasiou-Katsiardani A, Tanou K, et al. Evaluation of treatment and long-term management of anaphylaxis in pediatric departments of Greece: A 2-year nationwide survey. Allergol Immunopathol (Madr). 2024;1;52(3):8-16. [Crossref]  [PubMed]
  11. Dibek Misirlioglu E, Vezir E, Toyran M, Capanoglu M, Guvenir H, Civelek E, Kocabas CN. Clinical diagnosis and management of anaphylaxis in infancy. Allergy Asthma Proc. 2017;1;38(1):38-43. [Crossref]  [PubMed]
  12. Soyak Aytekin E, Şirin S, Kıratlı Nalbant E, Ata N, Sertçelik A, Ülgü MM, et al. Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database. World Allergy Organ J. 2024;24;18(1):101019. [Crossref]  [PubMed]  [PMC]
  13. Chiampou E, Douros K, Serbis A, Ladomenou F, Makis A, Siomou E, Tsabouri S. Anaphylaxis in infancy: An area that needs to be highlighted. Allergol Immunopathol (Madr). 2025;1;53(1):139-145. [Crossref]  [PubMed]
  14. Pouessel G, Alonzo S, Divaret-Chauveau A, Dumond P, Bradatan E, Liabeuf V, et al. Fatal and near-fatal anaphylaxis: the Allergy-VigilanceR Network data (2002-2020). Allergy. 2023;78(6):1628-38. [Crossref]  [PubMed]
  15. Pistiner M, Mendez-Reyes JE, Eftekhari S, Carver M, Lieberman J, Wang J, et al. Caregiver-Reported Presentation of Severe Food-Induced Allergic Reactions in Infants and Toddlers. J Allergy Clin Immunol Pract. 2021;9(1):311-320.e2. [Crossref]  [PubMed]
  16. Simons FE. Anaphylaxis in infants: can recognition and management be improved?. J Allergy Clin Immunol. 2007;120(3):537-540. [Crossref]  [PubMed]
  17. Abrams EM, Alqurashi W, Fischer DA, Vander Leek TK, Ellis AK. Anaphylaxis. Allergy Asthma Clin Immunol. 2024;9;20(Suppl 3):62. [Crossref]  [PubMed]  [PMC]
  18. Simons FE, Sampson HA. Anaphylaxis: unique aspects of Atakul Infant Anaphylaxis clinical diagnosis and management in infants (birth to age 2 years). J Allergy Clin Immunol. 2015;135(5):1125-1131. [Crossref]  [PubMed]
  19. Simons FER, Chan ES, Gu X, Simons KJ. Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical? J Allergy Clin Immunol. 2001;108(6):1040-1044. [Crossref]  [PubMed]
  20. Brown JC. Epinephrine, auto-injectors, and anaphylaxis: challenges of dose, depth, and device. Ann Allergy Asthma Immunol. 2018;121(1):53-60. [Crossref]  [PubMed]