Interleukin-1 Targeted Therapies in Pediatric Rheumatology

cocukromatolojisi-5-1-2024

Yağmur BAYINDIRa , Ezgi Deniz BATU AKALa , Seza ÖZENa

aHacettepe University Faculty of Medicine, Department of Paediatric Rheumatology, Ankara, Türkiye

ABSTRACT
In the 1970s, the identification of molecules initially termed leukocytic pyrogens paved the way for understanding the mechanism of fever. Subsequent purification and cloning in the 1980s revealed these molecules as interleukin-1 alpha and interleukin-1 beta. These potent inflammatory mediators, sharing the interleukin-1 receptor, are now recognized as part of the broader interleukin-1 family. Given their pivotal role in immune defense and immune-related conditions, pharmaceutical inhibitors, known as interleukin-1 blockers, are crucial in managing specific inflammatory and autoimmune disorders. In this review, we aimed to analyze the role of interleukin-1 inhibitors in paediatric rheumatology.
Keywords: Interleukin-1; Interleukin-1 inhibitors; anakinra; canakinumab; rilonacept

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