Irritant/Allergic Contact Dermatitis and Photosensitivity
Nihal ERTÜRK
Ankara Bilkent City Hospital, Clinic of EmergencyMedicine, Ankara, Türkiye
Habibe Selmin ÖZENSOY
Ankara Bilkent City Hospital, Clinic of EmergencyMedicine, Ankara, Türkiye
Ertürk N, Özensoy HS. Irritant/allergic contact dermatitis and photosensitivity. In: Oğuztürk H, Görmeli Kurt N, eds. Dermatologic Emergencies. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.103-8.
ABSTRACT
Allergic contact dermatitis is a delayed hypersensitivity reaction to skin contact with a foreign substance; skin changes occur after repeated exposure to the substance. In most patients, irritant and allergic contact dermatitis cannot be distinguished. In irritant contact dermatitis, the inflammatory reaction is mainly due to chemical and physical irritation. Photosensitivity is defined clinically as an exaggerated response to sunlight and is usually induced by UVA and/or UVB radiation. Photosensitivity may occur by photoallergic or phototoxic mechanisms. Phototoxic reactions occur in sun-exposed areas, while photoallergic reactions may also occur in non-sun-exposed areas. Phototoxic reactions begin within minutes to hours after exposure to the drug, while photoallergic reactions occur over a period of 24 hours or longer. In both cases, a good anamnesis and removal of the causative agent are required for diagnosis. In symptomatic treatment of photosensitivity, wet dressings, topical corticosteroids and antihistamines can be used. In severe reactions, short-term systemic corticosteroids can be started. Caution should be exercised as electrolyte disturbances due to widespread blistering and edema may develop in photosensitivity. Although the urgency triage rate is low in these two cases, sudden erythema is worrisome for people. Emergency physicians must be familiar with the subject. In this section, we aimed to define these two clinical situations and provide information about emergency department management.
Keywords: Allergic contact dermatitis; photosensitivity; emergency department
Kaynak Göster
Referanslar
- Nassau S, Fonacier L. Allergic Contact Dermatitis. Medical Clinics of North America. 2020;104(1):61-76. [Crossref] [PubMed]
- Gonçalo M. Phototoxic and Photoallergic Reactions. In: Johansen JD, Mahler v, Lepoittevin JP, Frosch PJ, eds. Contact Dermatitis. Cham: Springer International Publishing; 2020. p.1-25. [Crossref]
- Clark SC, Zirwas MJ. Management of occupational dermatitis. Dermatol Clin. 2009;27(3):365-83. vii-viii. [Crossref] [PubMed]
- Zawawi S, Yang YW, Cantwell HM, Drage LA, Youssef MJ, Yiannias JA, et al. Trends in Patch Testing With the Mayo Clinic Standard Series, 2017-2021. Dermatitis. 2023;34(5):405-12. [Crossref] [PubMed]
- Alinaghi F, Bennike NH, Egeberg A, Thyssen JP, Johansen JD. Prevalence of contact allergy in the general population: A systematic review and metaanalysis. Contact Dermatitis. 2019;80(2):77-85. [Crossref] [PubMed]
- Krob HA, Fleischer AB Jr, D'Agostino R Jr, Haverstock CL, Feldman S. Prevalence and relevance of contact dermatitis allergens: a meta-analysis of 15 years of published T.R.U.E. test data. J Am Acad Dermatol. 2004;51(3):349-53. [Crossref] [PubMed]
- Johansen JD. Fragrance contact allergy: a clinical review. Am J Clin Dermatol. 2003;4(11):789-98. [Crossref] [PubMed]
- Prakash Av, Davis MD. Contact dermatitis in older adults: a review of the literature. Am J Clin Dermatol. 2010;11(6):373-81. [Crossref] [PubMed]
- Hamann CR, Hamann D, Egeberg A, Johansen JD, Silverberg J, Thyssen JP. Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis. J Am Acad Dermatol. 2017;77(1):70-8. [Crossref] [PubMed]
- Owen JL, vakharia PP, Silverberg JI. The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. Am J Clin Dermatol. 2018;19(3):293-302. [Crossref] [PubMed] [PMC]
- Silverberg JI, Hou A, Warshaw EM, DeKoven JG, Maibach HI, Belsito Dv, et al. Prevalence and Trend of Allergen Sensitization in Adults and Children with Atopic Dermatitis Referred for Patch Testing, North American Contact Dermatitis Group Data, 2001-2016. J Allergy Clin Immunol Pract. 2021;9(7):2853-66.e14. [Crossref] [PubMed]
- Yamada T. Photosensitivity reaction induced by finasteride. J Gen Fam Med. 2022;23(3):185-6. [Crossref] [PubMed] [PMC]
- Usatine RP, Riojas M. Diagnosis and management of contact dermatitis. Am Fam Physician. 2010;82(3):249-55. [Link]
- Lugović L, Situm M, Ozanić-Bulić S, Sjerobabski-Masnec I. Phototoxic and photoallergic skin reactions. Coll Antropol. 2007;31 Suppl 1:63-7. [PubMed]
- Crisafulli G, Franceschini F, Caimmi S, Bottau P, Liotti L, Saretta F, et al. Mild cutaneous reactions to drugs. Acta Biomed. 2019;90(3-s):36-43. [PMC]
- Litchman G, Nair PA, Atwater AR, et al. Contact Dermatitis. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: [Link]
- Brites GS, Ferreira I, Sebastião AI, Silva A, Carrascal M, Neves BM, et al. Allergic contact dermatitis: From pathophysiology to development of new preventive strategies. Pharmacol Res. 2020;162:105282. [Crossref] [PubMed]