AUTOINFLAMMATORY DISEASES IN HEMATOLOGY FROM DIAGNOSIS TO TREATMENT

AUTOINFLAMMATORY_DISEASES_IN_HEMATOLOGY_FROM_DIAGNOSIS_TO_TREATMENTkapak

KIKUCHI DISEASE

Taha Ulutan Kars

Konya City Hospital, Department of Hematology, Konya, Türkiye

Kars TU. Kikuchi Disease. In: Kurt Yüksel M, editor. Autoinflammatory Diseases in Hematology from Diagnosis to Treatment. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.219-229.

ABSTRACT

Kikuchi-Fujimoto disease is a benign, self-limited inflammatory condition of unknown etiology that preferentially affects female patients under age 30, with a higher prevalence in East Asia. Patients present with subacute tender cervical lymphadenopathy, fever, and abdominal pain. No specific laboratory investigations are recommended for the diagnosis. The magnitude of polyclonal hypergammaglobulinemia can be usually modest, up to 25 g/L. Diagnosis requires an excisional lymph node biopsy; characteristic histopathologic findings include necrotizing lymphadenitis with karyorrhexis. Treatment is generally supportive, and nonsteroidal anti-inflammatory drugs or corticosteroids can be used for severe symptoms.

Keywords: Histiocytic necrotizing lymphadenitis; Inflammation

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