Leptospirosis in Laboratory Animals

veterinerbilichastaliklari10-3-24kapak

A. Cihat TUNÇa , Fatih M. BİRDANEa
aAfyon Kocatepe University Faculty of Veterinary Medicine, Department of Internal Medicine, Afyonkarahisar, Türkiye

ABSTRACT
Leptospirosis is an important zoonotic disease caused by Leptospira which can pose significant risks to both animal and human health worldwide. Leptospira can usually be found in kidney and urinary tract. Accordingly, the spread of the disease generally occurs through infected animals’ urine. The agent is especially prevalent in humid regions, hot climates, and places with lots of waterlogging. Many Leptospirosis-related studies have been conducted in laboratory/experimental animals. Hamsters are widely used in Leptospirosis studies. However, genetically modified mice and rats are also included in animal experiments. Studies conducted with Leptospirosis in laboratory animals provided the effects and treatments of Leptospira with different pathogenic properties and the development of vaccines against leptospirosis.

Keywords: Mice; jaundice; hemoglobinuria; Weil disease

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