MANAGEMENT OF BONE DISEASE IN MULTIPLE MYELOMA

Derya Deniz Kürekci1 Sude Hatun Aktimur2

1Samsun Education and Research Hospital, Department of Hematology, Samsun, Türkiye
2Samsun University, Faculty of Medicine, Department of Hematology, Samsun, Türkiye

Deniz Kürekci D, Aktimur SH. Management of Bone Disease in Multiple Myeloma. In: Sevindik ÖG, editor. Multiple Myeloma and Other Plasma Cell Dyscrasias. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.123-127.

ABSTRACT

Multiple myeloma bone disease is a serious condition that significantly affects patients’ quality of life and leads to skeletal complications. Treatment strategies aim to stop bone destruction and promote new bone formation. Bisphosphonates, denosumab, and proteasome inhibitors offer effective treatment methods for this disease. In addition, new biologic agents hold promise in the treatment of bone disease by reestablishing the balance between osteoblasts and osteoclasts.

Keywords: Multiple myeloma; Bone diseases

Referanslar

  1. Mukkamalla SKR, Malipeddi D. Myeloma Bone Disease: A Comprehensive Review. International Journal of Molecular Sciences. 2021;22:6208. [Crossref]  [PubMed]  [PMC]
  2. Terpos E, Dimopoulos MA. Multiple Myeloma-Related Bone Disease: Biology of Bone Destruction and Therapeutic Approaches. Hematology/Oncology Clinics of North America. 2020;34(3):649-659.
  3. Hideshima T, Anderson KC. Pathophysiology and Emerging Treatment Approaches of Multiple Myeloma. Clinical Advances in Hematology & Oncology. 2021;19(1):27-40.
  4. Dimopoulos MA, Kastritis E, Terpos E. Current and Emerging Treatments in Multiple Myeloma Bone Disease. Blood Reviews. 2019;33:74-81.
  5. Giuliani N, Ferretti M, Bolzoni M, et al. Increased Osteocyte Death in Multiple Myeloma Patients: Role in Myeloma-Induced Osteoclast Formation. Leukemia. 2012;26:1391-1401. [Crossref]  [PubMed]
  6. Terpos E, Berenson JR. Prognostic Variables for Survival and Skeletal Complications in Patients with Multiple Myeloma Osteolytic Bone Disease. Leukemia. 2010;24:10431049. [Crossref]  [PubMed]