MICROBIOTA

microbiotakapak

MICROBIOTA AND NEUROPROTECTION

Ali Rıza Gündüz1
Firdevs Ezgi Uçan Tokuç2

1Antalya Training and Research Hospital, Department of Neurology, Antalya, Türkiye
2Antalya Training and Research Hospital, Department of Neurology, Antalya, Türkiye

Gündüz AR, Uçan Tokuç FE. Microbiota and Neuroprotection. Melek İM, Aydoğan S, eds. Microbiota. 1sted. Ankara: Türkiye Klinikleri; 2025. p.185-195.

ABSTRACT

Healthy microbiota, healthy host, and the right dietary strategy have effects that protect nerve cells and prevent neuroinflammation and neurodegeneration.

The healthy commensal microbiota in our gut produce neurotransmitters, antioxidant and pro-inflammatory substances, and vitamins B and K, which exert neuroprotective effects. Microbiata exhibit neuroprotective effects by converting dietary substances into bioactive metabolites, interacting with host molecules, and recycling these molecules through glycolization and glucuronidation. The major mechanisms of neuroprotective effects can be listed as direct cell-to-cell chemical signaling, regulation of immune responses, neuroplasticity, and protection of neurons against inflammation and oxidation. The role of microbiota in neuroprotection offers hope for neurological diseases.

Keywords: Brain; Brain-gut axis; Diet; Neuroprotection; Neurodegenerattive disease

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