Mouse Hepatitis Virus

veterinerbilichastaliklari10-3-24kapak

Alanur BAKIRa , Ceren DİNLER AYa , Bülent ULUTAŞa
aAydın Adnan Menderes University Faculty of Veterinary Medicine, Department of Internal Medicine, Aydın, Türkiye

ABSTRACT
Coronaviruses (CoV) pose a significant threat to laboratory animals and often lead to infectious colony-wide devastation. Among these, Mouse Hepatitis Virus (MHV) is a prominent example. The biological behavior of MHV isolates differs according to organ tropisms as enterotropic and polytropic. Enterotropic strains have selective tropism for the intestinal epithelium. They induce devastation in the newborn mouse population with 100% morbidity. Polytropic strains show primary tropism for the upper respiratory tract epithelium, also secondary tropism for various cells or tissues. These strains enter through the nasal route and disseminate throughout the body via viremia, affecting organs such as the lungs, liver, bone marrow, brain, lymphoid tissue, and reproductive organs. Clinical signs may remain elusive in immunocompetent mice. However, immunodeficient mice are susceptible to acute encephalomyelitis associated with polytropic strain. This chapter aims to convey information from current perspectives about MHV.

Keywords: Coronavirus; laboratory animals; mouse hepatitis virus

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