NEUROANESTHESIA

Mehlika Kuşvuran Kurtay

Mersin City Training and Research Hospital, Department of Anesthesiology and Reanimation, Mersin, Türkiye

Kuşvuran Kurtay M. Neuroanesthesia. In: Kazancı D, editor. Anesthesiology Fast Review. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.273-286.

ABSTRACT

  • Neuroanesthetic management focuses on intracranial pressure and cerebral perfusion pressure. Elevated intracranial pressure can lead to a reduction in cerebral perfusion pressure. Moderate hyperventilation may temporarily reduce intracranial pressure.
  • The sitting position and certain neurosurgical procedures carry a high risk of venous air embolism. Sudden decrease in end-tidal carbon dioxide may suggest venous air embolism, although it is nonspecific.
  • Neurosurgical procedures are defined as moderateor high-risk procedures. In preoperative evaluation, detailed neurological examinations should be performed and documented.
  • Dexmedetomidine is increasingly used in neuroanesthesia due to its advantages. Altgough, it should be used cautiously in patients at risk for focal ischemia. If opioids are preferred for postoperative analgesia, minimal doses should be administered prior extubation. Scalp blocks allow patients to wake up with minimal pain without affecting neurological assessment.
  • During posterior fossa surgery, ischemia, surgical trauma and traction may damage brainstem structures. Sudden bradycardia and asystole suggest a vagal reflex. If cranial nerve injury is suspected, extubation should be delayed.
  • Before clipping the aneurysm, a temporary clip is often placed on the proximal artery. Prior to temporary clipping, hypotension can reduce bleeding and facilitate surgical manipulation. Although deep hypotension should be avoided.
  • Traumatic brain injury is frequently accompanied by other traumatic injuries. Cervical spine trauma should be assumed unless proven otherwise. Hypotension management should be initiated immediately, even prior to surgical intervention. The use of tranexamic acid has been demonstrated to be beneficial in moderate traumatic brain injury.
  • Awake craniotomy is increasingly utilized as an effective surgical approach. Conscious sedation and asleep-awake-asleep techniques are prominent in anesthesia management.
  • Patients with sellar pathology should be assessed for endocrine disorders. A thorough airway examination is essential. Imaging methods or flexible nasopharyngoscopy may be necessery to evaluate airway anatomy.
  • Controlled hypotension to reduce bleeding is not routinely recommended in spinal surgery. An effective strategy to reduce bleeding, perioperative complications, and transfusion is to initiate patient blood management preoperatively.

Keywords: Craniotomy; Intracranial pressure; Brain injuries; Traumatic; Intracranial aneurysm; Brain edema; Brain neoplasms; Neuroanesthesia

Referanslar

  1. Lemkuil BP, Drummond JC, Patel PM, Lam A. Anesthesia for neurologic surgery and neurointerventions. In: Miller RD, Cohen NH, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, editors. Miller's Anesthesia. 9th ed. Philadelphia: Elsevier; 2020;1868-1910. [Link]
  2. Desai VR, Sadrameli SS, Hoppe S, Lee JJ, Jenson A, Steele WJ 3rd, et al. Contemporary Management of Increased Intraoperative Intracranial Pressure: Evidence-Based Anesthetic and Surgical Review. World Neurosurg. 2019;129:120-129. [Crossref]  [PubMed]
  3. Himes BT, Mallory GW, Abcejo AS, Pasternak J, Atkinson JLD, Meyer FB, et al. Contemporary analysis of the intraoperative and perioperative complications of neurosurgical procedures performed in the sitting position. J Neurosurg. 2017;127(1):182-188. [Crossref]  [PubMed]
  4. Todd MM, McGovern R, Johnson A. Venous Air Embolism During Awake Deep Brain Stimulator Placement. J Neurosurg Anesthesiol. 2023;35(2):254-255. [Crossref]  [PubMed]
  5. Gracia I, Fabregas N. Craniotomy in sitting position: anesthesiology management. Curr Opin Anaesthesiol. 2014;27(5):474-83. [Crossref]  [PubMed]
  6. Abcejo AS, Pasternak JJ, Perkins WJ. Urgent Repositioning After Venous Air Embolism During Intracranial Surgery in the Seated Position: A Case Series. J Neurosurg Anesthesiol. 2019;31(4):413-421. [Crossref]  [PubMed]
  7. Gupta H, Gupta PK, Fang X, Miller WJ, Cemaj S, Forse RA, et al. Development and validation of a risk calculator predicting postoperative respiratory failure. Chest. 2011;140(5):1207-1215. [Crossref]  [PubMed]
  8. Gupta PK, Gupta H, Sundaram A, Kaushik M, Fang X, Miller WJ, et al. Development and validation of a risk calculator for prediction of cardiac risk after surgery. Circulation. 2011;124(4):381-7. [Crossref]  [PubMed]
  9. Guilfoyle MR, Helmy A, Duane D, Hutchinson PJA. Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis. Anesth Analg. 2013;116(5):1093-1102. [Crossref]  [PubMed]
  10. Berger M, Philips-Bute B, Guercio J, Hopkins TJ, James ML, Borel CO, et al. A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement. Curr Med Res Opin. 2014;30(2):243-50. [Crossref]  [PubMed]
  11. Butterworth Iv JF, Mackey DC, Wasnick JD. In: Morgan& Mikhail's Clinical Anesthesiology, 7e. New York, NY: McGraw-Hill Education; 2022;27. [Crossref]  [PubMed]
  12. Cole CD, Gottfried ON, Gupta DK, Couldwell WT. Total intravenous anesthesia: advantages for intracranial surgery. Neurosurgery. 2007;61(52):369-77; 377-8. [Crossref]  [PubMed]
  13. Wang L, Shen J, Ge L, Arango MF, Tang X, Moodie J, et al. Dexmedetomidine for craniotomy under general anesthesia: A systematic review and meta-analysis of randomized clinical trials. J Clin Anesth. 2019;54:114-125. [Crossref]  [PubMed]
  14. Gelb AW, Craen RA, Rao GS, Reddy KR, Megyesi J, Mohanty B, et al. Does hyperventilation improve operating condition during supratentorial craniotomy? A multicenter randomized crossover trial. Anesth Analg. 2008;106(2):585-94, table of contents. [Crossref]  [PubMed]
  15. Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, et al. Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med. 2007;35(2):568-78. [Crossref]  [PubMed]
  16. Czosnyka M, Smielewski P, Piechnik S, Steiner LA, Pickard JD. Cerebral autoregulation following head injury. J Neurosurg. 2001;95(5):756-63. [Crossref]  [PubMed]
  17. Chughtai KA, Nemer OP, Kessler AT, Bhatt AA. Post-operative complications of craniotomy and craniectomy. Emerg Radiol. 2019 Feb;26(1):99-107. [Crossref]  [PubMed]
  18. Mestdagh FP, Lavand'homme PM, Pirard G, Joshi GP, Sauter AR, Van de Velde M; PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA). Pain management after elective craniotomy: A systematic review with procedure-specific postoperative pain management (PROSPECT) recommendations. Eur J Anaesthesiol. 2023;40(10):747-757. [Crossref]  [PubMed]
  19. Rigamonti A, Garavaglia MM, Ma K, Crescini C, Mistry N, Thorpe K, et al. Effect of bilateral scalp nerve blocks on postoperative pain and discharge times in patients undergoing supratentorial craniotomy and general anesthesia: a randomized-controlled trial. Can J Anaesth. 2020;67(4):452-461. English. [Crossref]  [PubMed]
  20. Gaudray E, N' Guyen C, Martin E, Lyochon A, Dagain A, Bordes J, et al. Efficacy of scalp nerve blocks using ropivacaïne 0,75% associated with intravenous dexamethasone for postoperative pain relief in craniotomies. Clin Neurol Neurosurg. 2020;197:106125. [Crossref]  [PubMed]
  21. Galvin IM, Levy R, Day AG, Gilron I. Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery. Cochrane Database Syst Rev. 2019;2019(11):CD011931. [Crossref]  [PubMed]
  22. Sloan T. The incidence, volume, absorption, and timing of supratentorial pneumocephalus during posterior fossa neurosurgery conducted in the sitting position. J Neurosurg Anesthesiol. 2010;22(1):59-66. [Crossref]  [PubMed]
  23. Thibault M, Girard F, Moumdjian R, Chouinard P, Boudreault D, Ruel M. Craniotomy site influences postoperative pain following neurosurgical procedures: a retrospective study. Can J Anaesth. 2007;54(7):544-8. [Crossref]  [PubMed]
  24. Nassar H, Sarhan K, Gamil M, Elgohary M, El-Hadi H, Mahmoud S. Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy: A Randomized, Controlled Trial. J Neurosurg Anesthesiol. 2024;36(2):159-163. [Crossref]  [PubMed]
  25. Naidech AM, Drescher J, Ault ML, Shaibani A, Batjer HH, Alberts MJ. Higher hemoglobin is associated with less cerebral infarction, poor outcome, and death after subarachnoid hemorrhage. Neurosurgery. 2006;59(4):775-9; discussion 779-80. [Crossref]  [PubMed]
  26. Guinn NR, McDonagh DL, Borel CO, Wright DR, Zomorodi AR, Powers CJ, et al. Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. J Neurosurg Anesthesiol. 2011;23(1):35-40. [Crossref]  [PubMed]
  27. Irie T, Yoshitani K, Ohnishi Y, Shinzawa M, Miura N, Kusaka Y, et al. The efficacy of motor-evoked potentials on cerebral aneurysm surgery and new-onset postoperative motor deficits. J Neurosurg Anesthesiol. 2010;22(3):247-51. [Crossref]  [PubMed]
  28. Wiles MD. Management of traumatic brain injury: a narrative review of current evidence. Anaesthesia. 2022;77-1:102-112. [Crossref]  [PubMed]
  29. Bhattacharya B, Maung AA. Anesthesia for Patients with Traumatic Brain Injuries. Anesthesiol Clin. 2016;34(4):747-759. [Crossref]  [PubMed]
  30. Maheswari N, Panda NB, Mahajan S, Luthra A, Pattnaik S, Bhatia N, et al. Ketofol as an Anesthetic Agent in Patients With Isolated Moderate to Severe Traumatic Brain Injury: A Prospective, Randomized Double-blind Controlled Trial. J Neurosurg Anesthesiol. 2023;35(1):49-55. [Crossref]  [PubMed]
  31. CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019;394(10210):1713-1723. [Crossref]  [PubMed]
  32. Alali AS, McCredie VA, Golan E, Shah PS, Nathens AB. Beta blockers for acute traumatic brain injury: a systematic review and meta-analysis. Neurocrit Care. 2014;20(3):514-23. [Crossref]  [PubMed]
  33. Gerritsen JKW, Zwarthoed RH, Kilgallon JL, Nawabi NL, Jessurun CAC, Versyck G, et al. Effect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP): a propensity score-matched analysis of an international, multicentre, cohort study. Lancet Oncol. 2022;23(6):802-817. [Crossref]  [PubMed]
  34. Sattari SA, Rincon-Torroella J, Sattari AR, Feghali J, Yang W, Kim JE, et al. Awake Versus Asleep Craniotomy for Patients With Eloquent Glioma: A Systematic Review and Meta-Analysis. Neurosurgery. 2024;94(1):38-52. [Link]
  35. Kulikov A, Lubnin A. Anesthesia for awake craniotomy. Curr Opin Anaesthesiol. 2018;31(5):506-510. [Crossref]  [PubMed]
  36. Sewell D, Smith M. Awake craniotomy: anesthetic considerations based on outcome evidence. Curr Opin Anaesthesiol. 2019;32(5):546-552. [Crossref]  [PubMed]
  37. Stevanovic A, Rossaint R, Veldeman M, Bilotta F, Coburn M. Anaesthesia Management for Awake Craniotomy: Systematic Review and Meta-Analysis. PLoS One. 2016;11(5):e0156448. [Crossref]  [PubMed]  [PMC]
  38. Özlü O. Anaesthesiologist's Approach to Awake Craniotomy. Turk J Anaesthesiol Reanim. 2018;46(4):250-256. [Crossref]  [PubMed]  [PMC]
  39. Lodenius Å, Maddison KJ, Lawther BK, Scheinin M, Eriksson LI, Eastwood PR, et al. Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study. Anesthesiology. 2019;131(5):962-973. [Crossref]  [PubMed]
  40. Lodenius Å, Ebberyd A, Hårdemark Cedborg A, Hagel E, Mkrtchian S, Christensson E, et al. Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study. Anesthesiology. 2016;125(4):700-15. [Crossref]  [PubMed]
  41. Lee HC, Kim MK, Kim YH, Park HP. Radiographic Predictors of Difficult Laryngoscopy in Acromegaly Patients. J Neurosurg Anesthesiol. 2019;31(1):50-56. [Crossref]  [PubMed]
  42. Kim J, Scott-Miller R. Anesthesia for Pituitary Surgery. Otolaryngol Clin North Am. 2022;55(2):421-430. [Crossref]  [PubMed]
  43. Alharbi S, Harsh G, Ajlan A. Perioperative lumbar drain utilization in transsphenoidal pituitary resection. Neurosciences (Riyadh). 2018;23(1):46-51. [Crossref]  [PubMed]  [PMC]
  44. Aldosari N, Alrashid S, Alshareeda AH, Alenezi A, Alenezi MY, Almutairi A, et al. Dexmedetomidine in Patients Undergoing Transsphenoidal Resection of Pituitary Adenoma: An Updated Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Cureus. 2023;15(8):e44132. [Crossref]
  45. Raveendran K, Kwok S, Glancz L. Anaesthesia for pituitary surgery. BJA Educ. 2024;24(12):433-439. [Crossref]  [PubMed]
  46. Deyo RA, Mirza SK, Martin BI, Kreuter W, Goodman DC, Jarvik JG. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA. 2010;303(13):1259-65. [Crossref]  [PubMed]  [PMC]
  47. Singleton M, Ghisi D, Memtsoudis S. Perioperative management in complex spine surgery. Minerva Anestesiol. 2022;88(5):396-406. [Crossref]  [PubMed]
  48. Tonković D, Bandić Pavlović D, Baronica R, Virag I, Miklić Bublić M, Kovač N, et al. REGIONAL ANESTHESIA FOR NEUROSURGERY. Acta Clin Croat. 2019;58(1):48-52. [Crossref]  [PMC] /
  49. American Society of Anesthesiologists Task Force on Perioperative Visual Loss; North American Neuro-Ophthalmology Society; Society for Neuroscience in Anesthesiology and Critical Care. Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery 2019: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Visual Loss, the North American Neuro-Ophthalmology Society, and the Society for Neuroscience in Anesthesiology and Critical Care. Anesthesiology. 2019;130(1):12-30. [Crossref]  [PubMed]  [PMC]
  50. Li G, Sun TW, Luo G, Zhang C. Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: a meta-analysis. Eur Spine J. 2017;26(1):140-154. [Crossref]  [PubMed]