MODERN APPROACHES AND RECENT ADVANCES IN NEUROENDOCRINE TUMORS

Modern Approaches and Recent Advances in Neuroendocrine Tumors-kapak

NEW RADIOLOGICAL IMAGING APPROACHESIN GASTROINTESTINAL NEUROENDOCRINE TUMORS

Ayşenur Buz Yaşar

Bolu Abant İzzet Baysal University, Faculty of Medicine, Department of Radiology, Bolu, Türkiye

Buz Yaşar A. New Radiological Imaging Approaches in Gastrointestinal Neuroendocrine Tumors. In: Gönüllü E, Karaman K, editors. Modern Approaches and Recent Advances in Neuroendocrine Tumors. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.59-65.

ABSTRACT

Gastrointestinal neuroendocrine tumors (GI-NETs) are a rare and diverse spectrum of neoplasm, making up about 2% of all gastrointestinal cancers. Neuroendocrine tumors (NETs) are derived from primitive endoderm and can originate from any part of the gastrointestinal tract. NETs were historically believed to develop from neural crest cells. However, current evidence suggests that they arise from multi-potent stem cells. They are most commonly found in the small intestine (45%), followed by the rectum (20%), appendix (16%), colon (11%), pancreas (5%-10%), and stomach (7%). The incidence of detected cases is increasing, attributed to improvements in early tumor detection techniques. The World Health Organization (WHO) classifies GI-NETs and pancreatic NETs under a single category: gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). However, due to significant differences in their radiological features, this chapter specifically focused on GI-NETs.

Keywords: Neuroendocrine tumours; Neuroendocrine carcinoma; Intestinal neoplasms; Gastrointestinal tract; Diagnostic imaging

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