CURRENT CONCEPTS IN RADIOTHERAPY FOR BENIGN DISORDERS

CurrentConceptsinRadiotherapyforBenignDisorders1-0-25kapak

Obsessive Compulsive Disorder and Epilepsia

Çağdaş YAVAŞa , Fatih ÖZCANb
aSelçuk University Faculty of Medicine, Department of Radiation Oncology, Konya, Türkiye
bEtlik City Hospital, Clinic of Radiation Oncology, Ankara, Türkiye

Yavaş Ç, Özcan F. Obsessive compulsive disorder and epilepsia. In: Uysal B, Gamsız H, eds. Current Concepts in Radiotherapy for Benign Disorders. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.47-51.

ABSTRACT
Stereotactic radiosurgery (SRS) is a well-established non-invasive treatment for malignant brain tumors, but its use is increasing, especially in the treatment of non-malignant functional disorders such as epilepsy, tremor, trigeminal neuralgia, and obsessive-compulsive disorder (OCD), which are resistant to medical therapy and are inoperable. OCD is the most common psychiatric disorder treated with radiosurgery. Anterior capsulotomy via radiosurgery continues to be a valuable treatment choice for individuals with medically intractable OCD. Recent studies have shown that the frequency of seizures, especially from hypothalamic hamartomas and mesial temporal lobe epilepsies (MTLE), is significantly reduced with SRS treatment. Although the anticonvulsant effect of SRS is not clearly understood, neuromodulatory effects and ischemic necrosis of epileptic tissues are proposed mechanisms. As advances in engineering and computer-based radiosurgery planning continue, it will become even more important to define ideal neuroanatomical targets, select appropriate doses and determine patient selection criteria related to potential neurological and psychiatric disorders.

Keywords: Radiosurgery; obsessive-compulsive disorder (OCD); epilepsy

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