Overview of Biologic Agents in Pediatric Rheumatology

Veysel ÇAMa , Halide Özge BAŞARANa

aHacettepe University Faculty of Medicine, Department of Pediatric Rheumatology, Ankara, Türkiye

ABSTRACT
The pathophysiology of chronic inflammatory rheumatic illnesses has been addressed in a number of research over the past few decades. New treatment targets have been produced as a result of the improved understanding of the etiology of rheumatological illnesses. Biologics are a subset of the class of drugs called disease-modifying antirheumatic drugs (DMARDs). Biological drugs regulate specific responses such as B cell depletion, inhibition of T cell activation, and cytokine functions. Over the past 20 years, biologic agents have been widely used in many rheumatic diseases. New molecules are being used with efficacy in more and more indications. However, safety profiles and adverse events remain a concern. The aim of the review was to evaluate the mechanisms of action, clinical effectiveness, adverse effects and safety of biologic and small molecule drugs used for pediatric rheumatology.
Keywords: Rheumatology; pediatrics

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