PEDIATRIC ANESTHESIA

Cansu Çiftci

Konya City Hospital, Faculty of Medicine, Department of Anesthesiology and Reanimation, Konya, Türkiye

Çiftci C. Pediatric Anesthesia. In: Kazancı D, editor. Anesthesiology Fast Review. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.235-245.

ABSTRACT

  • Children under the age of three, particularly those born prematurely or with a recent history of upper respiratory tract infections, are at high risk for respiratory complications during anesthesia, necessitating thorough preoperative evaluation.
  • Preoperative fasting times should be adjusted based on the child’s age and medical condition to prevent hypoglycemia and dehydration while minimizing the risk of aspiration; the 6-4-1 rule offers advantages over the traditional 6-4-2 guideline.
  • Succinylcholine is primarily reserved for emergency rapid sequence intubation due to the associated risks of hyperkalemia and bradycardia, requiring close cardiac monitoring during administration.
  • Due to anatomical differences, pediatric airway management demands greater attention compared to adults; factors such as a relatively large tongue, a high larynx, and narrower airways increase the difficulty of intubation in infants.
  • Sevoflurane is the agent of choice for inhalational induction in pediatric anesthesia due to its minimal airway irritation and rapid onset, making it particularly suitable for facilitating the placement of a laryngeal mask airway.
  • Newborns are prone to rapid heat loss due to their large body surface area relative to mass; thus, active warming measures should be implemented intraoperatively, with careful monitoring of thermoregulation throughout the procedure.
  • In children recovering from upper respiratory tract infections, elective surgeries should be postponed for 2-4 weeks, as the risk of bronchospasm and laryngospasm remains elevated during this period.

Keywords: Anesthesia, pediatric; Airway management; Preoperative care; Respiratory complications; Thermoregulation; Sevoflurane; Postoperative nausea and vomiting; Fluid therapy.

Referanslar

  1. Sims C and Tanya F. "An overview of pediatric anesthesia." A Guide to Pediatric Anesthesia 2nd edt. Springer, Cham. 2020;1-26. [Crossref]  [PMC]
  2. Marciniak BCote CJ, Lerman J, Todres ID. Growth and development A Practice of Anaesthesia for Infants and Children. 4th ed Philadelphia, PA Saunders Elsevier:2009;7-21. [Crossref]
  3. Saikia, Diganta; Mahanta, Bandana. Cardiovascular and respiratory physiology in children. Indian Journal of Anaesthesia 2019;63(9):690-697. [Crossref]  [PubMed]  [PMC]
  4. Bromley PN, Rawlinson E, Harclerode Z, Bennett J. Developmental Physiology of the Liver, Gastrointestinal Tract, and Renal System. Gregory's Pediatric Anesthesia, 2020;164-190. [Crossref]
  5. Luginbuehl I, Bissonnett B, Davis PJ. Thermoregulation: physiology and perioperative disturbances. Smith's Anesthesia for Infants and Children E-Book: Expert Consult Premium. Mosby, 2001;157. [Crossref]
  6. Çiftci C, Kara I, Büyükcavlak M, Aslanlar, E. Effect of Perioperative Active Warming on Postoperative Pain and Shivering in Preschool Pediatric Patients: A Randomized Controlled Trial. Indian Pediatrics, 2024;61(9), 829-834. [Crossref]  [PubMed]
  7. Sims C, Thompson J. Pharmacology of Anesthetic Agents in Children. A Guide to Pediatric Anesthesia, 2020;27-53. [Link]
  8. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. British journal of clinical pharmacology, 2004;57(1):6-14. [Crossref]  [PubMed]  [PMC]
  9. Van den Anker J, Reed MD, Allegaert K, Kearns GL. Developmental changes in pharmacokinetics and pharmacodynamics. The Journal of Clinical Pharmacology, 2018;58: 10-S25. [Crossref]  [PubMed]
  10. Bartlett JW, Curry BN, Musick MA, Moore MM. Characterization of Propofol Use For Non-Procedural Sedation in a Pediatric Intensive Care Unit. The Journal of Pediatric Pharmacology and Therapeutics, 2023;28(8): 714-720. [Crossref]  [PubMed]  [PMC]
  11. Hayes JA, Aljuhani T, De Oliveira K, Johnston BC. Safety and Efficacy of the Combination of Propofol and Ketamine for Procedural Sedation/Anesthesia in the Pediatric Population: A Systematic Review and Meta-analysis. Anesth Analg. 2021;132(4):979-992. [Crossref]  [PubMed]
  12. Van Dijk, Huib MD; Hendriks, Mark P. MD; van Eck-Smaling, Marga M. BSc; van Wolfswinkel, Leo MD, PhD; van Loon, Kim MD, PhD. Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia. Anesthesia & Analgesia 2023;136(3):551-558. [Crossref]  [PubMed]  [PMC]
  13. Simonini A, Brogi E, Cascella M, Vittori A. Advantages of ketamine in pediatric anesthesia. Open Medicine, 2022;17(1): 1134-1147. [Crossref]  [PubMed]  [PMC]
  14. Jacobwitz M, Mulvihill C, Kaufman MC, Gonzalez AK, Resendiz K, Francoeur C, Abend NS. A comparison of ketamine and midazolam as first-line anesthetic infusions for pediatric status epilepticus. Neurocritical care, 2024;40(3): 984-995. [Crossref]  [PubMed]
  15. Shereef KM, Chaitali B, Swapnadeep S, Gauri M. Role of nebulised dexmedetomidine, midazolam or ketamine as premedication in preschool children undergoing general anaesthesia-A prospective, double-blind, randomised study. Indian Journal of Anaesthesia, 2022;66(4):200-206. [Crossref]  [PubMed]  [PMC]
  16. Kumar, Nishant; Bansal, Gunjan; Jain, Aruna. A study of the relationship between Bispectral index and age-adjusted minimum alveolar concentration during the maintenance phase of general anesthesia in elective surgery. Journal of Anaesthesiology Clinical Pharmacology 2024;40(4):626-632. [Crossref]  [PubMed]  [PMC]
  17. Nickalls RWD, Mapleson WW. Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man. British journal of anaesthesia, 2023;91(2):170-174. [Crossref]  [PubMed]
  18. Ing C, Brambrink AM. Mayo Anesthesia Safety in Kids continued: two new studies and a potential redirection of the field. British journal of anaesthesia, 2019;122(6):716-719. [Crossref]  [PubMed]
  19. Davidson AJ, Morton NS, Arnup SJ, De Graaff JC, Disma N, Withington DE, GAS Consortium. Apnea after awake-regional and general anesthesia in infants: the General Anesthesia compared to Spinal anesthesia (GAS) study: comparing apnea and neurodevelopmental outcomes, a randomized controlled trial. Anesthesiology, 2015;123(1):38. [Crossref]  [PubMed]  [PMC]
  20. Warner DO, Zaccariello MJ, Katusic SK, Schroeder DR, Hanson AC, Schulte PJ, Flick RP. Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: The MASK study. Anesthesiology, 2018;129(1):89. [Crossref]  [PubMed]  [PMC]
  21. Apai C, Shah R, Tran K, Shah SP. Anesthesia and the developing brain: a review of sevoflurane-induced neurotoxicity in pediatric populations. Clinical therapeutics, 2021;43(4):762-778. [Crossref]  [PubMed]
  22. Dimic N, Djuric M, Nenadic I. et al. Nitrous Oxide - Application in Modern Anesthesia. Curr Anesthesiol 2023;13:117-123. [Crossref]
  23. Farag RS, Spicer AC, Iyer G, Stevens JP, King A, Bain P A, McAlvin JB. Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An updated systematic review and meta-analysis. Pediatric Anesthesia, 2024;34(4):304-317. [Crossref]  [PubMed]
  24. Regli A, Sommerfield A, von Ungern-Sternberg BS. Anesthetic considerations in children with asthma. Pediatric Anesthesia, 2022;32(2):148-155. [Crossref]  [PubMed]
  25. Totonchi Z, Siamdoust SAS, Zaman B, Rokhtabnak F, Alavi SA. Comparison of laryngeal mask airway (LMA) insertionwith and without muscle relaxant in pediatric anesthesia; a randomized clinical trial. Heliyon, 2022;8(11). [Crossref]  [PubMed]  [PMC]
  26. Vanlinthout LE, Driessen JJ, Stolker RJ, Lesaffre EM, Berghmans JM, Staals LM. Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta-analytic and meta-regression approach. Pediatric Anesthesia. 2024; doi: 10.1111/pan.14908. [Crossref]  [PubMed]
  27. Aslanidis T, Barros V, Bersot CDA. Introductory Chapter: Pharmacology of Airway Management in Emergency Medicine. In Airway Management in Emergency Medicine. IntechOpen. 2023; doi: 10.5772/intechopen.1002408. [Crossref]
  28. Chhabra R, Gupta R, Gupta LK. Sugammadex versus neostigmine for reversal of neuromuscular blockade in adults and children: a systematic review and meta-analysis of randomized controlled trials. Current Drug Safety, 2024;19(1):33-43. [Crossref]  [PubMed]
  29. Qiao H, Chen J, Lv P, Ye Z, Lu Y, Li W, Jia J. Efficacy of premedication with intravenous midazolam on preoperative anxiety and mask compliance in pediatric patients: a randomized controlled trial. Transl Pediatr. 2022;11(11):1751-1758. [Crossref]  [PubMed]  [PMC]
  30. Lethin M, Paluska MR, Petersen TR, Falcon R, Soneru C. Midazolam for Anesthetic Premedication in Children: Considerations and Alternatives. Cureus. 2023;15(12):50309. [Crossref]  [PubMed]  [PMC]
  31. Bromfalk Å, Hultin M, Myrberg T, Engström Å, Walldén, J. Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine. Pediatric Anesthesia, 2023;33(11):962-972. [Crossref]  [PubMed]
  32. Sousa-Júnior FA, Souza AS, Lima LC, Santos ÍG, Menezes LA, Ratis PA, Couceiro TC. Intraoperative clonidine to prevent postoperative emergence delirium following sevoflurane anesthesia in pediatric patients: a randomized clinical trial. Brazilian Journal of Anesthesiology, 2021;71(1): 5-10. [Crossref]  [PubMed]  [PMC]
  33. Zhang D, Jia X, Lin D, Ma, J. Melatonin or its analogs as premedication to prevent emergence agitation in children: a systematic review and meta-analysis. BMC anesthesiology, 2023;23(1):392. [Crossref]  [PubMed]  [PMC]
  34. Li Y, Jiang Y, Zhang L. The effect of different dosage of intranasal dexmedetomidine on preventing emergence delirium or agitation in children: A network meta-analysis of randomized controlled trials. Plos one, 2024;19(9):0304796. [Crossref]  [PubMed]  [PMC]
  35. Kovac AL. Postoperative Nausea and Vomiting in Pediatric Patients. Pediatr Drugs 2021;23:11-37. [Crossref]  [PubMed]
  36. Eberhart LH, Geldner G, Kranke P, Morin AM, Schäufelen A, Treiber H, et al. The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesth Analg. 2004;99(6):1630-7 doi: 10.1213/01.ANE.0000135639.57715.6C. [Crossref]  [PubMed]
  37. Kubala ME, Turner M, Gardner JR, Williamson A, Richter GT. Impact of Oral Steroids on Tonsillectomy Postoperative Complications and Pain. Ear, Nose & Throat Journal. 2023;102(5):206-211. [Crossref]  [PubMed]
  38. Disma, Nicola; Asai, Takashi; Cools, Evelien; et al. Airway management in neonates and infants: European Society of Anaesthesiology and Intensive Care and British Journal of Anaesthesia joint guidelines. European Journal of Anaesthesiology 2024;41(1):3-23. [Crossref]  [PubMed]  [PMC]
  39. Algorithms for IV fluid therapy in children and young people in hospital. Available from: [Link]
  40. Lee H, Kim JT. Pediatric perioperative fluid management. Korean J Anesthesiol. 2023;76(6):519-530. [Crossref]  [PubMed]  [PMC]
  41. Eaddy N, Watene C. Perioperative management of fluids and electrolytes in children. BJA Educ. 2023;23(7):273-278. [Crossref]  [PubMed]  [PMC]
  42. Weiss M, Vutskits L, Hansen TG, Engelhardt T. Safe Anesthesia For Every Tot - The SAFETOTS initiative. Curr Opin Anaesthesiol. 2015;28(3):302-307. [Crossref]  [PubMed]
  43. De Graaff JC, Johansen MF, Hensgens M, Engelhardt, T. Best practice & research clinical anesthesiology: safety and quality in perioperative anesthesia care. Update on safety in pediatric anesthesia. Best Practice & Research Clinical Anaesthesiology, 2021;35(1):27-39. [Crossref]  [PubMed]