Periodontal Hastalıkların Biyokimyası
Ahmet Mert Nalbantoğlu, Şule Bulut
Bu bölüm, periodontal ve periimplant hastalıklarındaki moleküler değişiklikleri ele almaktadır. Evrensel düzeyde mücadele programlarına dâhil edilmesi gereken önlenebilir
ve bulaşıcı olmayan bu hastalık grubunun tedavisinde ilk adım, hastalığın doğru teşhisinin gerçekleştirilmesi ve prognozun öngörülebilmesidir. Bu noktada, moleküler
değişikliklerin bilinmesi klinik süreçler için faydalıdır. Aynı zamanda sağlıklı diş destek dokularının da biyokimyasal yapısı, hastalıkların tedavisinde ve önlenmesindeki kilit noktalardan birini oluşturur. Bu nedenle bu bölüm, patolojilere ek olarak sağlıklı diş destek dokuların biyokimyasal yapılarının da tanımını yapmaktadır. Çünkü diş sert doku kaybı restoratif tekniklerle rehabilite edilebilirken periodontal desteği oldukça azalmış dişler fonksiyon gösterememektedir. Periodontal Hastalıkların Biyokimyası bölümü, sağlıklı diş destek dokularının benzersiz biyokimyasal yapısı ve farklı periodontal hastalıklardaki değişikleri hakkında, periodontoloji biliminde yol haritasını aydınlatabilecek bilgiler sağlamayı hedeflemiştir.
Referanslar
- Ahmad, P., Arshad, A. I., Della Bella, E., Khurshid, Z., & Stoddart, M. (2020). Systemic manifestations of the periodontal disease: a bibliometric review. Molecules, 25(19), 4508. [Crossref]
- Airila-Månsson, S., Söder, B., Kari, K., & Meurman, J. H. (2006). Infuence of Combinations of Bacteria on the Levels of Prostaglandin E2, Interleukin-1β, and Granulocyte Elastase in Gingival Crevicular Fluid and on the Severity of Periodontal Disease. Journal of Periodontology, 77(6), 1025-1031. [Crossref]
- Alexander, M. B. and Damoulis, P. D. (1994). The role of cytokines in the pathogenesis of periodontal disease, Curr. Opin. Periodontol., 39-53.
- Al-Sabbagh, M., Alladah, A., Lin, Y., Kryscio, R. J., Thomas, M. V., Ebersole, J. L., & Miller, C. S. (2012). Bone remodeling-associated salivary biyobelirteç MIP-1α distinguishes periodontal disease from health. Journal of Periodontal Research, 47(3), 389-395. [Crossref]
- Ansel, J. C., Tiesman, J. P., Olerud, J. E., Krueger, J. G., Krane, J. F., Tara, D. C., ... & Hart, C. E. (1993). Human keratinocytes are a major source of cutaneous platelet-derived growth factor. Journal of Clinical Investigation, 92(2), 671-678. [Crossref]
- Arıkan, F., Buduneli, N., & Kütükçüler, N. (2008). Osteoprotegerin levels in peri-implant crevicular fuid. Clinical Oral Implants Research, 19(3), 283-288. [Crossref]
- Ataoglu, H., Alptekin, N. O., Haliloglu, S., Gursel, M., Ataoglu, T., Serpek, B., & Durmus, E. (2002). Interleukin-1β, tumor necrosis factor-α levels and neutrophil elastase activity in peri-implant crevicular fuid: Correlation with clinical parameters and effect of smoking. Clinical Oral Implants Research, 13(5), 470-476. [Crossref]
- Barnes, V. M., Ciancio, S. G., Shibly, O., Xu, T., Devizio, W., Trivedi, H. M., ... & Jönsson, T. J. (2011). Metabolomics reveals elevated macromolecular degradation in periodontal disease. Journal of Dental Research, 90(11), 1293-1297. [Crossref]
- Bartold, P., Walsh, L., & Narayanan, A. (2000). Molecular and cell biology of the gingiva. Periodontology. (Singapur). 24 (1): 2855. [Crossref]
- Becker, S. T., Beck-Broichsitter, B. E., Graetz, C., Dörfer, C. E., Wiltfang, J., & Häsler, R. (2014). Peri-implantitis versus periodontitis: functional differences indicated by transcriptome profling. Clinical implant dentistry and related research, 16(3), 401-411. [Crossref]
- Bezerra Júnior, A. A., Pallos, D., Cortelli, J. R., Saraceni, C. H. C., & Queiroz, C. S. (2010). Evaluation of organic and inorganic compounds in the saliva of patients with chronic periodontal disease. Revista odnto ciência, 25, 234-238. [Crossref]
- Bozkurt, F. Y., Berker, E., Akkuş, S., & Bulut, Ş. (2000). Relationship between interleukin-6 levels in gingival crevicular fuid and periodontal status in patients with rheumatoid arthritis and adult periodontitis. Journal of Periodontology, 71(11), 1756-1760. [Crossref]
- Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L., Jepsen, S., Kornman, K. S., ... & Tonetti, M. S. (2018). A new classifcation scheme for periodontal and peri-implant diseases and conditions-Introduction and key changes from the 1999 classifcation. Journal of Periodontology, 89, S1-S8. [Crossref]
- Costa, P. P., Trevisan, G. L., Macedo, G. O., Palioto, D. B., Souza, S. L., Grisi, M. F., ... & Taba Jr, M. (2010). Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. Journal of Periodontology, 81(3), 384-391. [Crossref]
- Cox, S. W., Rodriguez-Gonzalez, E. M., Booth, V., & Eley, B. M. (2006). Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fuid and saliva from patients with chronic periodontitis. Journal of Periodontal Research, 41(5), 477-485. [Crossref]
- Dale, B. A., Kimball, J. R., Krisanaprakornkit, S., Roberts, F., Robinovitch, M., O'Neal, R., ... & Weinberg, A. (2001). Localized antimicrobial peptide expression in human gingiva. Journal of Periodontal Research, 36(5), 285-294. [Crossref]
- Dutzan, N., Vernal, R., Hernandez, M., Dezerega, A., Rivera, O., Silva, N., ... & Gamonal, J. (2009). Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis. Journal of Periodontology, 80(2), 290-296. [Crossref]
- Ebersole, J. L., Schuster, J. L., Stevens, J., Dawson, D., Kryscio, R. J., Lin, Y., ... & Miller, C. S. (2013). Patterns of salivary analytes provide diagnostic capacity for distinguishing chronic adult periodontitis from health. Journal of Clinical Immunology, 33, 271-279. [Crossref]
- Ebersole, J. L., Schuster, J. L., Stevens, J., Dawson, D., Kryscio, R. J., Lin, Y., ... & Miller, C. S. (2013). Patterns of salivary analytes provide diagnostic capacity for distinguishing chronic adult periodontitis from health. Journal of clinical immunology, 33, 271-279. [Crossref]
- Eley, B. M., & Cox, S. W. (1996). The relationship between gingival crevicular fuid cathepsin B activity and periodontal attachment loss in chronic periodontitis patients: a 2-year longitudinal study. Journal of Periodontal Research, 31(6), 381-392. [Crossref]
- Ertugrul, A. S., Sahin, H., Dikilitas, A., Alpaslan, N., & Bozoglan, A. (2013). Comparison of CCL28, interleukin-8, interleukin-1β and tumor necrosis factor-alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis. Journal of Periodontal Research, 48(1), 44-51. [Crossref]
- Faizuddin, M., Bharathi, S. H., & Rohini, N. V. (2003). Estimation of interleukin-1β levels in the gingival crevicular fuid in health and in infammatory periodontal disease. Journal of periodontal research, 38(2), 111-114. [Crossref]
- Fassbender, W. J., Steinhauer, B., Stracke, H., Schumm-Draeger, P. M., & Usadel, K. H. (2002). Validation of a new automated immunoassay for measurement of intact osteocalcin. Clinical Laboratory, 48(1-2), 31-38.
- Fine, D. H., Markowitz, K., Furgang, D., Fairlie, K., Ferrandiz, J., Nasri, C., ... & Gunsolley, J. (2009). Macrophage infammatory protein-1α: a salivary biomarker of bone loss in a longitudinal cohort study of children at risk for aggressive periodontal disease? Journal of Periodontology, 80(1), 106-113. [Crossref]
- Grbic, J. T., Lamster, I. B., Fine, J. B., Lam, K. S., Celenti, R. S., Herrera-Abreu, M., & Singer, R. E. (1999). Changes in gingival crevicular fuid levels of immunoglobulin A following therapy: association with attachment loss. Journal of Periodontology, 70(10), 1221-1227. [Crossref]
- Grotendorat, G. R., Igarashi, A., Larson, R., Soma, Y. and Charette, M. (1991). Differential binding, biological and biochemical actions of recombinant PDGF AA. AB and BB molecules on connective tissue cells, Journal of Cell Physiology. 1492, 235-243. [Crossref]
- Gürkan, A., Emingil, G., Çınarcık, S., & Berdeli, A. (2006). Gingival crevicular fuid transforming growth factor-β1 in several forms of periodontal disease. Archives of Oral Biology, 51(10), 906-912. [Crossref]
- Hart, C. E., Fornstrom, J. W. Kelly, J. D., Smith, R. A, Ross, R., Murray, M. J. and Bowen-Pope, D. F. (1988). Two classes of PDGF receptors recognize different isoforms of PDGF, Science, 240, 1529-1531. [Crossref]
- Huynh, Q. N., Wang, S., Tafolla, E., Gansky, S. A., Kapila, S., Armitage, G. C., & Kapila, Y. L. (2002). Specifc fbronectin fragments as markers of periodontal disease status. Journal of Periodontology, 73(10), 1101-1110. [Crossref]
- Isaza-Guzmán, D. M., Arias-Osorio, C., Martínez-Pabón, M. C., & Tobón-Arroyave, S. I. (2011). Salivary levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1: A pilot study about the relationship with periodontal status and MMP-9− 1562C/T gene promoter polymorphism. Archives of Oral Biology, 56(4), 401-411. [Crossref]
- James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., ... & Briggs, A. M. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1789-1858. [Crossref]
- Kähäri, V. M., Larjava, H., & Uitto, J. (1991). Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fbroblast PG) but down-regulates decorin (PGII) mRNA levels in human fbroblasts in culture. Journal of Biological Chemistry, 266(16), 10608-10615.66. Cantley, L. C., Anger, K. R., Carpenter, C., Duckworth, B., Gaziani, A., Kapeller, R. and Soltoff, S. (1991). Oncogenes and signal transduction, Cell, 64, 281-302. [Crossref]
- Kalsi, A. S., Moreno, F., & Petridis, H. (2021). Biyobelirteçs associated with periodontitis and peri-implantitis: a systematic review. Journal of Periodontal & Implant Science, 51(1), 3. [Crossref]
- Khiste, S. V., Ranganath, V., Nichani, A. S., & Rajani, V. (2011). Critical analysis of biomarkers in the current periodontal practice. Journal of Indian Society of Periodontology, 15(2), 104. [Crossref]
- Koller, A., & Sapra, A. (2020). Anatomy, head and neck, oral gingiva. StatPearls Publishing, Treasure Island (FL).
- Lang, N. P., Berglundh, T., Giannobile, W. V., & Sanz, M. (Eds.). (2021). Lindhe's clinical periodontology and implant dentistry. John Wiley & Sons.
- Liskmann, S., Vihalemm, T., Salum, O., Zilmer, K., Fischer, K., & Zilmer, M. (2006). Correlations Between Clinical Parameters and lnterleukin-6 and lnterleukin-10 Levels in Saliva from Totally Edentulous Patients with Peri-implant Disease. International Journal of Oral & Maxillofacial Implants, 21(4).
- Liukkonen, J., Gürsoy, U. K., Pussinen, P. J., Suominen, A. L., & Könönen, E. (2016). Salivary concentrations of interleukin (IL)-1β, IL-17A, and IL-23 vary in relation to periodontal status. Journal of Periodontology, 87(12), 1484-1491. [Crossref]
- Melguizo-Rodríguez, L., Costela-Ruiz, V. J., Manzano-Moreno, F. J., Ruiz, C., & Illescas-Montes, R. (2020). Salivary biyobelirteçs and their application in the diagnosis and monitoring of the most common oral pathologies. International Journal of Molecular Sciences, 21(14), 5173. [Crossref]
- Minabe, M. (1991). A critical review of the biologic rational for guided tissue regeneration, Journal of Periodontology, 62, 17 1-179. [Crossref]
- Minabe, M. (1991). A critical review of the biologic rationale for guided tissue regeneration. Journal of Periodontology, 62(3), 171-179. [Crossref]
- Mogi, M., & Otogoto, J. (2007). Expression of cathepsin-K in gingival crevicular fuid of patients with periodontitis. Archives of oral biology, 52(9), 894-898. [Crossref]
- Nazir, M., Al-Ansari, A., Al-Khalifa, K., Alhareky, M., Gaffar, B., & Almas, K. (2020). Global prevalence of periodontal disease and lack of its surveillance. The Scientifc World Journal, 2020. [Crossref]
- Ohshima, M., Fujikawa, K., Akutagawa, H., Kato, T., Ito, K., & Otsuka, K. (2002). Hepatocyte growth factor in saliva: a possible marker for periodontal disease status. Journal of Oral Science, 44(1), 35-39. [Crossref]
- Oringer, R. J., Howell, T. H., Nevins, M. L., Reasner, D. S., Davis, G. H., Sekler, J., & Fiorellini, J. P. (2001). Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression. Journal of Periodontology, 72(1), 17-24. [Crossref]
- Parsons, J. T., Schaller, M. D., Hildebrand, J., Leu, T. H., Richardson, A., & Otey, C. (1994). Focal adhesion kinase: structure and signalling. Journal of Cell Science, 109-113. [Crossref]
- Pradeep, A. R., Hadge, P., Chowdhry, S., Patel, S., & Happy, D. (2009). Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease. Journal of Oral Science, 51(2), 261-266. [Crossref]
- Pradeep, A. R., Roopa, Y., & Swati, P. P. (2008). Interleukin-4, a T-helper 2 cell cytokine, is associated with the remission of periodontal disease. Journal of Periodontal Research, 43(6), 712-716. [Crossref]
- Prakasam, S., & Srinivasan, M. (2014). Evaluation of salivary biyobelirteç profles following non-surgical management of chronic periodontitis. Oral Diseases, 20(2), 171-177. [Crossref]
- Reinhardt, R. A., McDonald, T. L., Bolton, R. W., DuBois, L. M., & Kaldahl, W. B. (1989). IgG subclasses in gingival crevicular fuid from active versus stable periodontal sites. Journal of Periodontology, 60(1), 44-50. [Crossref]
- Roccuzzo, A., Stähli, A., Monje, A., Sculean, A., & Salvi, G. E. (2021). Peri-implantitis: a clinical update on prevalence and surgical treatment outcomes. Journal of Clinical Medicine, 10(5), 1107.25. [Crossref]
- Schroeder, H. E. (1992). Biological problems of regenerative cementogenesis: synthesis and attachment of collagenous matrices on growing and established root surfaces. International review of cytology, 142, 1-59. [Crossref]
- Siegbahn, A., Hammacher, A., Westermark, B., & Heldin, C. H. (1990). Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fbroblasts, monocytes, and granulocytes. Journal of Clinical Investigation, 85(3), 916-920. [Crossref]
- Slack, J. L., Liska, D. J., & Bornstein, P. (1993). Regulation of expression of the type I collagen genes. American Journal of Medical Genetics, 45(2), 140-151. [Crossref]
- Tsai, C. C., Ho, Y. P., Ho, K. Y., Wu, Y. M., & Hung, C. C. (2005). Interleukin-12 and interleukin-16 in periodontal disease. Cytokine, 31(1), 34-40. [Crossref]
- Türkoğlu, O., Emingil, G., Kütükçüler, N., & Atilla, G. (2009). Gingival crevicular fuid levels of cathelicidin LL-37 and interleukin-18 in patients with chronic periodontitis. Journal of Periodontology, 80(6), 969-976. [Crossref]
- Uematsu, S., Mogi, M., & Deguchi, T. (1996). Interleukin (IL)-1β, IL-6, tumor necrosis factor-α, epidermal growth factor, and β2-microglobulin levels are elevated in gingival crevicular fuid during human orthodontic tooth movement. Journal of Dental Research, 75(1), 562-567. [Crossref]
- Ülker, A. E., Tulunoglu, Ö., Özmeric, N., Can, M., & Demirtas, S. (2008). The evaluation of cystatin C, IL1β, and TNF-α levels in total saliva and gingival crevicular fuid from 11-to 16-year-old children. Journal of Periodontology, 79(5), 854-860. [Crossref]
- Vadiati Saberi, B., Yousef, F., Yousef, T., & Qujeq, D. (2022). Assessment of mucin and alpha-amylase levels in gingival crevicular fuid of chronic periodontitis patients. Oral Diseases, 28(1), 210-215. [Crossref]
- Wei, P. F., Ho, K. Y., Ho, Y. P., Wu, Y. M., Yang, Y. H., & Tsai, C. C. (2004). The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1β in gingival crevicular fuid: implications for oxidative stress in human periodontal diseases. Journal of Periodontal Research, 39(5), 287-293. [Crossref]
- Wikesjo, U. M. E., Nilveus, R. E. and Selvig, K. A. (1992). Signifcance of early wound healing events in periodontal repair: A review, Journal of Periodontology. 63, 158-163. [Crossref]
- Wong, D. T. (2006). Salivary diagnostics powered by nanotechnologies, proteomics and genomics. The Journal of the American Dental Association, 137(3), 313-321. [Crossref]
- Wu, Y. C., Ning, L., Tu, Y. K., Huang, C. P., Huang, N. T., Chen, Y. F., & Chang, P. C. (2018). Salivary biyobelirteç combination prediction model for the diagnosis of periodontitis in a Taiwanese population. Journal of the Formosan Medical Association, 117(9), 841-848. [Crossref]
- Xu, L., Yu, Z., Lee, H. M., Wolff, M. S., Golub, L. M., Sorsa, T., & Kuula, H. (2008). Characteristics of collagenase-2 from gingival crevicular fuid and peri-implant sulcular fuid in periodontitis and peri-implantitis patients: pilot study. Acta Odontologica Scandinavica, 66(4), 219-224. [Crossref]
- Yaprak, E., Kasap, M., Akpınar, G., Kayaaltı-Yüksek, S., Sinanoğlu, A., Guzel, N., & Demirturk Kocasarac, H. (2018). The prominent proteins expressed in healthy gingiva: a pilot exploratory tissue proteomics study. Odontology, 106, 19-28. [Crossref]
- Yavuzyilmaz, E., Yamalik, N., Bulut, S., Özen, S., Ersoy, F., & Saatpi, Ü. (1995). The gingival crevicular fuid Interleukin-1β and tumour necrosis factor-α levels in patients with rapidly progressive periodontitis. Australian Dental Journal, 40(1), 46-49. [Crossref]
- Yücel, Ö. Ö., Berker, E., Gariboğlu, S., & Otlu, H. (2008). Interleukin-11, interleukin-1β, interleukin-12 and the pathogenesis of infammatory periodontal diseases. Journal of Clinical Periodontology, 35(5), 365-370. [Crossref]