Pharmacokinetic Changes in the Elderly

farmakoloji-11-2-2023-wos

Celil İlker AŞKINa , Gökçe Sevim ÖZTÜRK FİNCANa

aGazi University Faculty of Medicine, Department of Medical Pharmacology, Ankara, Türkiye

ABSTRACT
In elderly patients, concurrent diseases can occur, therefore the elderly require more prescriptions. The term pharmacokinetics refers to what the body does to the medicine, and it covers four primary areas which are absorption, distribution, metabolism, and elimination. Deterioration due to old age in physiological functions causes changes in pharmacokinetic parameters in the elderly. Due to reduced gastric acid production, gastric motility, and blood flow, absorption can be altered in older patients. Alterations in body composition such as decline in body water levels and increase in body fat levels affect the distribution of drugs. With aging, liver mass and hepatic blood flow decreases, in return, clearance of substances that are metabolized in the liver decreases. With aging kidney function is affected therefore drug clearance is altered. When treating elderly patients, approaching with caution can be advised since these changes can be dangerous due to possible toxicities or unfavorable treatment outcomes.
Keywords: Pharmacokinetics; aging

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