PHYSICAL EXAMINATION IN OBSTRUCTIVE SLEEP APNEA

Süreyya Hikmet Kozcu

Muğla Sıtkı Koçman University, Faculty of Medicine, Department of Otorhinolaryngology, Muğla, Türkiye

Kozcu SH. Physical Examination in Obstructive Sleep Apnea. In: Özcan KM, editor. Sleep-Disordered Breathing: Diagnosis and Treatment. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.33-43.

ABSTRACT

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder affecting approximately 1 billion adults worldwide, characterized by recurrent episodes of complete or partial upper airway collapse during sleep. These events lead to oxygen desaturation (typically below 90%), sleep fragmentation, and excessive daytime sleepiness, with significant cardiovascular and metabolic consequences including hypertension, coronary artery disease, and insulin resistance. The physical examination serves as a critical diagnostic tool, enabling clinicians to identify anatomical risk factors, predict disease severity, and guide personalized treatment decisions. The standardized examination protocol begins with anthropometric measurements, where a body mass index (BMI) ≥30 kg/m² (particularly ≥35 kg/m²) and neck circumference >43 cm in males or >40 cm in females represent significant risk factors. Craniofacial assessment focuses on identifying retrognathia (SNA angle <80°), micrognathia, and maxillary constriction through careful inspection and cephalometric analysis when indicated. Nasal examination includes evaluation of septal deviation using anterior rhinoscopy, assessment of nasal valve collapse via Cottle maneuver, and grading of turbinate hypertrophy (mild: ≤50% obstruction, moderate: 5075%, severe: >75%). The oropharyngeal examination incorporates Mallampati classification (Class III-IV indicating higher risk), tonsil size grading using the Brodsky scale, uvular characteristics (length

>1.5 cm, edema, bifurcation), and Müller’s maneuver to assess dynamic airway collapse during inspiration. Laryngopharyngeal inspection evaluates tongue base hypertrophy (Edinburgh Tongue Scale), lingual tonsils, and epiglottic morphology. These findings are integrated using validated clinical scoring systems: the Friedman staging system combines palate position, tonsil size and BMI to predict surgical outcomes, while the Fujita classification categorizes anatomical levels of obstruction. Advanced diagnostic adjuncts include drug-induced sleep endoscopy (DISE) using the VOTE classification system and volumetric magnetic resonance imaging (MRI) for airway assessment. This comprehensive approach facilitates phenotype-specific treatment selection, from positive airway pressure therapy to surgical interventions like uvulopalatopharyngoplasty or hypoglossal nerve stimulation. The protocol also enhances prediction of treatment adherence and outcomes, while supporting multidisciplinary collaboration between sleep specialists, otolaryngologists, and dentists. Future research directions include standardization of examination techniques across populations, and validation of novel imaging modalities for dynamic airway assessment during sleep.

Keywords: Obstructive sleep apnea; Physical examination; Airway obstruction; Body mass index; Palatine tonsil; Tongue

Referanslar

  1. Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7(8):687-698. [Crossref]  [PubMed]
  2. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006-1014. [Crossref]  [PubMed]  [PMC]
  3. Friedman M, Tanyeri H, La Rosa M, Landsberg R, Vaidyanathan K, Pieri S, et al. Clinical predictors of obstructive sleep apnea. Laryngoscope. 1999;109(12):1901-1907. [Crossref]  [PubMed]
  4. Epstein LJ, Kristo D, Strollo PJ Jr, Friedman N, Malhotra A, Patil SP, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263-276. [Crossref]
  5. Ravesloot MJL, de Vries N. Reliable calculation of the efficacy of non-surgical and surgical treatment of obstructive sleep apnea revisited. Sleep. 2011;34(1):105-110. [Crossref]  [PubMed]  [PMC]
  6. Kezirian EJ, Hohenhorst W, de Vries N. Drug-induced sleep endoscopy: the VOTE classification. Eur Arch Otorhinolaryngol. 2011;268(8):1233-1236. [Crossref]  [PubMed]
  7. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004;291(16):2013-2016. [Crossref]  [PubMed]
  8. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284(23):3015-3021. [Crossref]
  9. Simpson L, Mukherjee S, Cooper MN, Ward KL, Lee JD, Fedson AC, et al. Sex differences in the association of re gional fat distribution with the severity of obstructive sleep apnea. Sleep. 2010;33(4):467-474. [Crossref]  [PubMed]  [PMC]
  10. Davies RJ, Ali NJ, Stradling JR. Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome. Thorax. 1992;47(2):101-105. [Crossref]  [PubMed]  [PMC]
  11. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA. 2000;283(14):1829-1836. [Crossref]  [PubMed]
  12. Fava C, Dorigoni S, Vedove FD, Danese E, Montagnana M, Guidi GC, et al. Effect of CPAP on blood pressure in patients with OSA/hypopnea a systematic review and meta-analysis. Chest. 2014;145(4):762-771. [Crossref]  [PubMed]
  13. Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, et al. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015;1:15015. [Crossref]
  14. Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med. 2003;168(5):522-530. [Crossref]  [PubMed]
  15. Cistulli PA, Palmisano RG, Poole MD. Treatment of obstructive sleep apnea syndrome by rapid maxillary expansion. Sleep. 1998;21(8):831-835. [Crossref]  [PubMed]
  16. Friedman M, Ibrahim H, Bass L. Clinical staging for sleep-disordered breathing. Otolaryngol Head Neck Surg. 2002;127(1):13-21. [Crossref]  [PubMed]
  17. Rhee JS, Poetker DM, Smith TL, Senior BA, Sung CK, Yaremchuk KL, et al. Nasal valve surgery improves disease-specific quality of life. Laryngoscope. 2005;115(3):437-440. [Crossref]  [PubMed]
  18. Berger G, Gass S, Ophir D. The histopathology of the hypertrophic inferior turbinate. Arch Otolaryngol Head Neck Surg. 2006;132(6):588-594. [Crossref]  [PubMed]
  19. Spielmann PM, White PS, Hussain SS. Surgical techniques for the treatment of nasal valve collapse: a systematic review. Laryngoscope. 2009;119(7):1281-1290. [Crossref]  [PubMed]
  20. Brodsky L. Modern assessment of tonsils and adenoids. Pediatr Clin North Am. 1989;36(6):1551-1569. [Crossref]  [PubMed]
  21. Ottaviano G, Scadding GK, Coles S, Lund VJ. Peak nasal inspiratory flow; normal range in adult population. Rhinology. 2006;44(1):32-35. [Crossref]
  22. Li HY, Lee LA, Wang PC, Chen NH, Fang TJ, Lin HC, et al. Nasal surgery for snoring in patients with obstructive sleep apnea. Laryngoscope. 2008;118(2):354-359. [Crossref]  [PubMed]
  23. Nuckton TJ, Glidden DV, Browner WS, Claman DM. Physical examination: Mallampati score as an independent predictor of obstructive sleep apnea. Sleep. 2006;29(7):903-908. [Crossref]  [PubMed]
  24. Friedman M, Salapatas AM, Bonzelaar LB. Updated Friedman staging system for obstructive sleep apnea. Adv Otorhinolaryngol. 2017;80:41-48. [Crossref]  [PubMed]
  25. Sher AE, Thorpy MJ, Shprintzen RJ, Spielman AJ, Burack B, McGregor P. Predictive value of Müller maneuver in selection of patients for uvulopalatopharyngoplasty. Laryngoscope. 1985;95(12):1483-1487. [Crossref]  [PubMed]
  26. De Vito A, Carrasco Llatas M, Vanni A, Bosi M, Braghiroli A, Campanini A, et al. European position paper on drug-induced sleep endoscopy: 2017 Update. Clin Otolaryngol. 2018;43(6):1541-1552. [Crossref]  [PubMed]
  27. Vroegop AV, Vanderveken OM, Dieltjens M, Wouters K, Saldien V, Braem MJ, et al. Sleep endoscopy with simulation bite for prediction of oral appliance treatment outcome. J Sleep Res. 2013;22(3):348-355. [Crossref]  [PubMed]
  28. Ravesloot MJL, de Vries N. Reliable calculation of the efficacy of non-surgical and surgical treatment of obstructive sleep apnea revisited. Sleep. 2011;34(1):105-110. [Crossref]  [PubMed]  [PMC]
  29. Certal VF, Pratas R, Guimarães L, Lugo R, Tsou Y, Camacho M, et al. Awake examination versus DISE for surgical decision making in patients with OSA: A systematic review. La ryngoscope. 2016;126(3):768-774. [Crossref]  [PubMed]
  30. Pépin JL, Veale D, Ferretti GR, Mayer P, Lévy PA. Obstructive sleep apnea syndrome: hooked appearance of the soft palate in awake patients cephalometric and CT findings. Radiology. 1999;210(1):163-170. [Crossref]
  31. Fujita S, Conway W, Zorick F, Roth T. Surgical correction of anatomic abnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg. 1981;89(6):923-934. [Crossref]  [PubMed]
  32. Friedman M, Lin HC, Gurpinar B, Joseph NJ. Minimally invasive single-stage multilevel treatment for obstructive sleep apnea/hypopnea syndrome. Laryngoscope. 2007;117(10):1859-1863. [Crossref]  [PubMed]
  33. Woodson BT, Strohl KP, Soose RJ, Gillespie MB, Maurer JT, de Vries N, et al. Upper airway stimulation for obstructive sleep apnea: 5-year outcomes. Otolaryngol Head Neck Surg. 2018;159(1):194-202. [Crossref]  [PubMed]
  34. Vana KD, Silva GE, Goldberg R. Predictive abilities of the STOP-Bang and Epworth Sleepiness Scale in identifying sleep clinic patients at high risk for obstructive sleep apnea. Res Nurs Health. 2013;36(1):8494. [Crossref]  [PubMed]
  35. Pang KP, Terris DJ. Modified cautery-assisted palatal stiffening operation: new method for treating snoring and mild obstructive sleep apnea. Otolaryngol Head Neck Surg. 2007;136(5):823-826. [Crossref]  [PubMed]
  36. Campanini A, Canzi P, De Vito A, Dallan I, Montevecchi F, Vicini C. Awake versus sleep endoscopy: personal experience in 250 OSAHS patients. Acta Otorhinolaryngol Ital. 2010;30(2):73-77.
  37. Rabelo FAW, Küpper DS, Sander HH, Fernandes RMF, Valera FCP. Polysomnographic evaluation of propofol-induced sleep in patients with respiratory sleep disorders and controls. Laryngoscope. 2013;123(9):23002305. [Crossref]  [PubMed]
  38. Vicini C, De Vito A, Benazzo M, Frassineti S, Campanini A, Frasconi P, et al. The nose oropharynx hypopharynx and larynx (NOHL) classification: a new system of diagnostic standardized examination for OSAHS patients. Eur Arch Otorhinolaryngol. 2012;269(4):1297-1300. [Crossref]  [PubMed]
  39. Eichler C, Sommer JU, Stuck BA, Hörmann K, Maurer JT. Does drug-induced sleep endoscopy change the treatment concept of patients with snoring and obstructive sleep apnea? Sleep Breath. 2013;17(1):63-68. [Crossref]  [PubMed]
  40. Lowe AA, Ono T, Ferguson KA, Pae EK, Ryan CF, Fleetham JA. Cephalometric comparisons of craniofacial and upper airway structure by skeletal subtype and gender in patients with obstructive sleep apnea. Am J Orthod Dentofacial Orthop. 1996;110(6):653-664. [Crossref]  [PubMed]
  41. Hochban W, Brandenburg U, Peter JH. Surgical treatment of obstructive sleep apnea by maxillomandibular advancement. Sleep. 1994;17(7):624-629. [Crossref]  [PubMed]
  42. Suto Y, Matsuda E, Inoue Y, Suzuki T, Ohta Y. Sleep apnea syndrome: comparison of MR imaging of the oropharynx with physiologic indexes. Radiology. 1996;201(2):393-398. [Crossref]  [PubMed]
  43. Trudo FJ, Gefter WB, Welch KC, Gupta KB, Maislin G, Schwab RJ. State-related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects. Am J Respir Crit Care Med. 1998;158(4):1259-1270. [Crossref]  [PubMed]
  44. Safiruddin F, Vanderveken OM, de Vries N, Maurer JT, Lee K, Ni Q, et al. Effect of upper-airway stimulation for obstructive sleep apnoea on airway dimensions. Eur Respir J. 2015;45(1):129-138. [Crossref]  [PubMed]