FROM NEUROSCIENCE LABORATORY TO NEUROLOGY CLINIC

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POSTERIOR CORTICAL ATROPHY AND COGNITIVE REHABILITATION APPROACHES

Özden Erkan Oğul

İstanbul Medipol University, Faculty of Health Sciences, Department of Ergotherapy, İstanbul, Türkiye

Erkan Oğul Ö. Posterior Cortical Atrophy and Cognitive Rehabilitation Approaches. In: Hanoğlu L, editor. From Neuroscience Laboratory to Neurology Clinic. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.93104.

ABSTRACT

Posterior Cortical Atrophy (PCA), is a type of dementia with progressive course, known as the visual variant of Alzheimer’s disease. While it decreases productivity of person with its early age of onset, it also causes the limitations in basic and enstrumental daily life activities by creating visuospatial problems. Nonpharmacological approaches such as cognitive rehabilitation are gaining importance in the treatment of the disease, which has no effective pharmacological treatment. It is stated in the literature that the disease can create very different clinical symptoms depending on the area it affects, and that individualbased approaches should be used according to the clinical symptoms and personal characteristics of the person when creating a cognitive rehabilitation program. Remedial approaches that include training for impaired cognitive skills, compensatory approaches such as the use of strategies and environmental modifications, and brain stimulation methods are among the cognitive rehabilitation interventions used. Studies in the field of PCA have been limited to case studies. Future studies are needed to prove the effectiveness of the cognitive rehabilitation interventions used.

Keywords: Neurodegenerative diseases; Cognition disorders; Perceptual disorders; Rehabilitation

Referanslar

  1. Benson DF, Davis RJ, Snyder BD. Posterior cortical atrophy. Arch Neurol 1988;45:789793. [Crossref]  [PubMed]
  2. Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, et al. Genetic risk factors for the PCA variant of Alzheimer's disease. Alzheimers Dement 2016;12:86271. [Crossref]  [PubMed]  [PMC]
  3. TangWai DF, GraffRadford NR, Boeve BF, Dickson DW, Parisi JE, et al. Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology 2004;63:11681174 org/ [Crossref]  [PubMed]
  4. Snowden JS, Stopford CL, Julien CL, Thompson JC, Davidson Y, et al. Cognitive phenotypes in Alzheimer's disease and genetic risk. Cortex. 2007;43:83545. [Crossref]  [PubMed]
  5. Schott JM, Crutch SJ. Posterior cortical atrophy. Continuum (Minneap Minn). 2019;25(1):5275. [Crossref]  [PubMed]  [PMC]
  6. Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, et al. Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest Area. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017 Aug;13(8):870884. [Crossref]  [PubMed]  [PMC]
  7. Lehmann M, Crutch SJ, Ridgway GR, Ridha BH, Barnes J, et al. Cortical thickness and voxelbased morphometry in posterior cortical atrophy and typical Alzheimer's disease. Neurobiol Aging. 2011;32:146676. [Crossref]  [PubMed]
  8. Caso F, Agosta F, Mattavelli D, Migliaccio R, Canu E, et al. White matter degeneration in atypical Alzheimer disease. Radiology. 2015;277:162-72. [Crossref]  [PubMed]
  9. Migliaccio R, Agosta F, Possin KL, Rabinovici GD, Miller BL, GornoTempini ML. White matter atrophy in Alzheimer's disease variants. Alzheimers Dement. 2012:8:S78-87. [Crossref]  [PubMed]  [PMC]
  10. Migliaccio R, Gallea C, Kas AA, Perlbarg V, Samri D, et al. Functional connectivity of ventral and dorsal visual streams in posterior cortical atrophy. J Alzheimers Dis. 2016;51:1119-3. [Crossref]  [PubMed]
  11. Lehmann M, Madison C, Ghosh PM, Miller ZA, Greicius MD, et al. Loss of functional connectivity is greater outside the default mode network in nonfamilial earlyonset Alzheimer's disease variants. Neurobiol Aging. 2015;36:2678-86. [Crossref]  [PubMed]  [PMC]
  12. Andrade K, Samri D, Sarazin M, de Souza LC, Cohen L, et al. Visual neglect in posterior cortical atrophy. BMC Neurol. 2010;10:68.68.pdf [Crossref]  [PubMed]  [PMC]
  13. Chen Y, Liu P, Wang Y and Peng G. Neural Mechanisms of Visual Dysfunction in Posterior Cortical Atrophy. Front. Neurol. 2019;10:670. [Crossref]  [PubMed]  [PMC]
  14. Agosta F, MandicStojmenovic G, Canu E, Stojkovic T, Imperiale F, et al. Functional and structural brain networks in posterior cortical atrophy: a twocentre multiparametric MRI study. NeuroImage. 2018;19:901-10. [Crossref]  [PubMed]  [PMC]
  15. Maia da Silva MN, Millington RS, Bridge H, JamesGalton M, Plant GT. Visual Dysfunction in Posterior Cortical Atrophy. Front. Neurol. 2017;8:389. [Crossref]  [PubMed]  [PMC]
  16. Pelak VS, Smyth SF, Boyer PJ, Filley CM. Computerized visual field defects in posterior cortical atrophy. Neurology. 2011;77:211922. [Crossref]  [PubMed]
  17. Migliaccio R, Agosta F, Scola E, Magnani G, Cappa SF, , et al. Ventral and dorsal visual streams in posterior cortical atrophy: a DT MRI study. Neurobiol Aging. 2012;33:2572-84. [Crossref]  [PubMed]  [PMC]
  18. Neitzel J, Ortner M, Haupt M, Redel P, Grimmer T, et al. Neurocognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy. Brain. 2016;139:3267-80. [Crossref]  [PubMed]
  19. Pavisic IM, Firth NC, Parsons S, Rego DM, Shakespeare TJ, et al. Eyetracking metrics in young onset Alzheimer's disease: a window into cognitive visual functions. Front Neurol. 2017;8:377. [Crossref]  [PubMed]  [PMC]
  20. Millington RS, JamesGalton M, Maia DSM, Plant GT, Bridge H. Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits. Neuroimage Clin. 2017;14:242-9. [Crossref]  [PubMed]  [PMC]
  21. Yong KXX, Shakespeare TJ, Cash D, Henley SMD, Warren JD, Crutch SJ. (Con) textspecific effects of visual dysfunction on reading in posterior cortical atrophy. Cortex. 2014;57:92-106. [Crossref]  [PubMed]  [PMC]
  22. McMonagle P, Deering F, Berliner Y, Kertesz A. The cognitive profile of posterior cortical atrophy. Neurology. 2006;66:331-8. [Crossref]  [PubMed]
  23. Aresi A, Giovagnoli AR. The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer's disease. J Alzheimers Dis. 2009;18, 65-70. [Crossref]  [PubMed]
  24. Tsai PH, Teng E, Liu C, Mendez MF. Posterior cortical atrophy: Evidence for discrete syndromes of earlyonset Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2011;26, 413-418. [Crossref]  [PubMed]  [PMC]
  25. Cappa A, Ciccarelli N, Baldonero E, Martelli M, Silveri MC. Posterior ADtype pathology: cognitive subtypes emerging from a cluster analysis. Behav Neurol. 2014;2014:259358. [Crossref]  [PubMed]  [PMC]
  26. Agosta F, MandicStojmenovic G, Canu E, Stojkovic T, Imperiale F, et al. Functional and structural brain networks in posterior cortical atrophy: a twocentre multiparametric MRI study. NeuroImage. 2018;19:901-10. [Crossref]  [PubMed]  [PMC]
  27. Yerstein O, Parand L, Liang LJ, Isaac A, Mendez MF. Benson's Disease or Posterior Cortical Atrophy, Revisited. J Alzheimers Dis. 2021;82(2):493502. [Crossref]  [PubMed]  [PMC]
  28. Crutch SJ, Lehmann M, Schott JM, Rabinovici GD, Rossor MN, Fox NC. Posterior cortical atrophy. Lancet Neurol 2012;11:170-8. [Crossref]  [PubMed]
  29. WeillChounlamountry A, Poncet F, Crop S, Hesly N, Mouton A, et al. Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy. Annals of physical and rehabilitation medicine. 2012;55(6), 430439. [Crossref]  [PubMed]
  30. Kennedy J, Lehmann M, Sokolska MJ, Archer H, Warrington EK., et al. Visualizing the emergence of posterior cortical atrophy. Neurocase, 2012;18(3):248257. [Crossref]  [PubMed]
  31. Mendez M. F. Visuospatial deficits with preserved reading ability in a patient with posterior cortical atrophy. Cortex; a journal devoted to the study of the nervous system and behavior, 2001;37(4), 535543. [Crossref]  [PubMed]
  32. Shaji KS, Sivakumar PT, Rao GP, Paul N. Clinical Practice Guidelines for Management of Dementia. Indian journal of psychiatry. 2018;60(Suppl 3):312-328. [Crossref]  [PubMed]  [PMC]
  33. Borruat FX. Posterior cortical atrophy: review of the recent literature. Current neurology and neuroscience reports. 2013;13(12):406. [Crossref]  [PubMed]
  34. Wong B, Lucente DE, MacLean J, Padmanabhan J, Quimby M, et al. Diagnostic evaluation and monitoring of patients with posterior cortical atrophy. Neurodegenerative disease management, 2019;9(4):217239. [Crossref]  [PubMed]  [PMC]
  35. North C, Desai R, Saunders R, SuárezGonzález A, Bamiou D, et al. Neuropsychological deficits in Posterior Cortical Atrophy and typical Alzheimer's disease: A metaanalytic review. Cortex; a journal devoted to the study of the nervous system and behavior. 2021;143:223236. [Crossref]  [PubMed]
  36. WeillChounlamountry A, Alves J, PradatDiehl P. Nonpharmacological intervention for posterior cortical atrophy. World J Clin Cases 2016;4(8):195201 nih.gov/articles/PMC4983688/pdf/WJCC4195.pdf [Crossref]  [PubMed]  [PMC]
  37. Roca M, Gleichgerrcht E, Torralva T, Manes F. Cognitive rehabilitation in posterior cortical atrophy. Neuropsychol Rehabil. 2010;Aug;20(4):52840. [Crossref]  [PubMed]
  38. Gramegna LL, Evangelisti S, Testa C, Baiardi S, Mitolo M, Capellari S, et al. Cognitive Rehabilitation and Transcranial Direct Current Stimulation in a Patient with Posterior Cortical Atrophy: An fMRI Study. Am J Case Rep. 2018 Jun 21;19:729733. [Crossref]  [PubMed]  [PMC]
  39. Lefaucheur JP: A comprehensive database of published tDCS clinical trials (2005-2016) MOTS CLÉS. Neurophysiol Clin Neurophysiol, 2016;46: 319-98. [Crossref]  [PubMed]
  40. Vestito L, Trombini M, Mori L, Dellepiane S, Trompetto C, Morando M, et al. Improved visuospatial neglect after tDCS and computerassisted cognitive training in Posterior Cortical Atrophy: a singlecase study. Neurocase. 2021 Feb;27(1):5763. [Crossref]  [PubMed]
  41. Sanches C, Stengel C, Godard J, Mertz J, Teichmann M, et al. Past, Present, and Future of Noninvasive Brain Stimulation Approaches to Treat Cognitive Impairment in Neurodegenerative Diseases: Time for a Comprehensive Critical Review. Front Aging Neurosci. 2021 Jan 20;12:578339. [Crossref]  [PubMed]  [PMC]
  42. Sale MV, Mattingley JB, Zalesky A, Cocchi L. Imaging human brain networks to improve the clinical efficacy of noninvasive brain stimulation. Neurosci Biobehav Rev. 2015 Oct;57:18798. [Crossref]  [PubMed]
  43. Dugas CS, KeltnerDorman E, Hart J Jr. Differential effects from cognitive rehabilitation and highdefinition tDCS in posterior cortical atrophy: A singlecase experimental design. Neuropsychol Rehabil. 2022;32(7):16201642. [Crossref]  [PubMed]
  44. Kudlicka A, Martyr A, BaharFuchs A, Sabates J, Woods B, Clare L. Cognitive rehabilitation for people with mild to moderate dementia. Cochrane Database Syst Rev. 2023;6(6):CD013388. Published 2023 Jun 29. [Crossref]  [PubMed]  [PMC]
  45. Quintana LA. Remediating cognitive impairments. In: Trombly CA, editor. Occupational Therapy for Physical Dysfunction. 4th ed. Baltimore: Williams&Wilkins. 1995. p. 539-48.
  46. Anderson ND, Winocur G, Palmer H. Principles of cognitive rehabilitation. In: Gurd J, Kischka U, Marshall J, editors. The Handbook of Clinical Neuropsychology. 2nd ed. Oxford: Oxford University Press; 2010. p. 50-77. [Crossref]
  47. Alves J, Magalhães R, Arantes M, Cruz S, Gonçalves ÓF, Sampaio A. Cognitive rehabilitation in a visual variant of Alzheimer's disease. Appl Neuropsychol Adult. 2015;22(1):738. Epub 2013 Dec 9. [Crossref]  [PubMed]
  48. Grieve J, Gnanasekaran L. Neuropyschology for occupation al therapists: cognition in occupational performance. Oxford: Blackgnwell Publishing; 2010.
  49. Toglia JP. Cognitiveperceptual retraining and rehabilitaiton. In: Crepeau EB, Cohn ES, Schell BAB, editors. Willard&Spackman's Occupational Therapy. Philadelphia: Lippincott Williams&Wilkins; 2003. p. 607-29.
  50. Yong KXX, McCarthy ID, Poole T, Suzuki T, Yang B, Carton AM, et al. Navigational cue effects in Alzheimer's disease and posterior cortical atrophy. Annals of clinical and translational neurology. 2018;5(6), 697-709. [Crossref]  [PubMed]  [PMC]
  51. Tatsumi H, Yamamoto M, Yasui K, Miyake T. Clinical significance of cognitive rehabilitation and psychoeducational intervention for family caregivers of patients with posteri or cortical atrophy: a longitudinal study. Psychogeriatrics. 2018 Jan;18(1):7778.29372599. [Crossref]  [PubMed]
  52. Gillen G. Overview of cognitive and perceptual rehabilitation. Cognitive and perceptual rehabilitation. Washington: Mosby; 2009.p. 1-31. [Crossref]
  53. Letts L, Minezes J, Edwards M, Berenyi J, Moros K, O'Neill C, et al. Effectiveness of interventions designed to modify and maintain perceptual abilities in people with Alzheimer's disease and related dementias. Am J Occup Ther. 2011;65(5):50513.22026318. [Crossref]  [PubMed]