Pulpa ve Periapikal Doku Hastalıklarının Biyokimyası
Deniz Yanık, Fügen Dağlı Cömert
Bu bölüm, pulpa ve periapikal doku hastalıklarının oluşumuna ve bu hastalık tablolarındaki çeşitli moleküler, genetik değişikliklere ve aktif sinyal yolaklarına odaklanmaktadır. Ayrıca, yüksek rejenerasyon kapasitesine sahip pulpa dokusunun sağlıktaki durumunu da biyokimyasal açıdan ortaya koymaktadır. Pulpal hastalıkların çoğu diş hekimliğinin acil tedavi gerektiren, bu yüzden hızlı ve doğru teşhis ve tedavi planı ihtiyacının en yüksek olduğu patoloji gruplarından birini oluşturur. Ne yazık ki pulpa hastalıkların klinik teşhis yöntemleri ile tanısı, pulpadaki enfeksiyonun derecesi ve dokudaki yaygınlığı hakkında bilgi sağlama konusunda yetersiz kalabilmektedir. Bu nedenle, pulpal hastalıklardaki moleküler ve genetik haritaların oluşturulması, endodonti bilimi için yeni teşhis yöntemlerinin kapısını aralayabilir. Daha ileri teşhis yöntemlerinin gelişmesi ise, gereksiz tedavilerin uygulanmasını engelleyerek dişin canlılığının daha uzun süre korunabilmesini sağlayabilir. Pulpa ve Periapikal Doku Hastalıklarının Biyokimyası bölümü, pulpa hastalıkları ve sağlığındaki biyokimyasal durumu ve değişiklikleri ortaya koymakta ve bu moleküler değişikliklerin önemine defaatle vurgu yapmaktadır.
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