Radiology in Childhood Tuberculosis

Ceren Ayça YILDIZa , Yasemin GÖKDEMİRa

aMarmara University Faculty of Medicine, Department of Pediatric Chest Diseases, İstanbul, Türkiye

ABSTRACT
Childhood pulmonary tuberculosis (TB) remains a significant global health concern, demanding early and accurate diagnosis to ensure timely intervention and prevention of disease spread. Imaging techniques have played a pivotal role in the diagnosis and monitoring of pediatric TB, offering invaluable insights into the disease’s clinical presentation, progression, and treatment response. A combination of imaging techniques is indispensable for the comprehensive evaluation of childhood pulmonary TB. These modalities, ranging from traditional chest radiography to advanced computed tomography, magnetic resonance imaging, and emerging technologies, contribute significantly to the early diagnosis, accurate staging, and monitoring of pediatric TB cases. Integrating these imaging tools into a multidisciplinary approach is crucial for improving clinical outcomes and reducing the burden of childhood TB worldwide.
Keywords: Tuberculosis; lymphadenopathy; diagnostic imaging; ultrasonography; magnetic resonance imaging

Referanslar

  1. Concepcion NDP, Laya BF, Andronikou S, Abdul Manaf Z, Atienza MIM, Sodhi KS. Imaging recommendations and algorithms for pediatric tuberculosis: part 1-thoracic tuberculosis. Pediatr Radiol. 2023;53:1773-81. [Crossref]  [PubMed]  [PMC]
  2. Dolin PJ, Raviglione MC, Kochi A. Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ. 1994;72:213-20.
  3. Pillay T, Andronikou S, Zar HJ. Chest imaging in paediatric pulmonary TB. Paediatr Respir Rev. 2020;36:65-72. [Crossref]  [PubMed]
  4. Sodhi KS, Bhalla AS, Mahomed N, Laya BF. Imaging of thoracic tuberculosis in children: current and future directions. Pediatr Radiol. 2017;47:1260-68. [Crossref]  [PubMed]
  5. Palmer M, Gunasekera KS, van der Zalm MM, Morrison J, Simon Schaaf H, Goussard P, et al. The Diagnostic Accuracy of Chest Radiographic Features for Pediatric Intrathoracic Tuberculosis. Clin Infect Dis. 2022;75:1014-21. [Crossref]  [PubMed]  [PMC]
  6. Du Toit G, Swingler G, Iloni K. Observer variation in detecting lymphadenopathy on chest radiography. Int J Tuberc Lung Dis. 2002;6:814-7.
  7. Jain SK, Andronikou S, Goussard P, Antani S, Gomez-Pastrana D, Delacourt C, et al. Advanced imaging tools for childhood tuberculosis: potential applications and research needs. Lancet Infect Dis. 2020;20:e289-e97. [Crossref]  [PubMed]
  8. Concepcion NDP, Laya BF, Andronikou S, Daltro PAN, Sanchez MO, Uy JAU, et al. Standardized radiographic interpretation of thoracic tuberculosis in children. Pediatr Radiol. 2017;47:1237-48. [Crossref]  [PubMed]  [PMC]
  9. Andronikou S, Vanhoenacker FM, De Backer AI. Advances in imaging chest tuberculosis: blurring of differences between children and adults. Clin Chest Med. 2009;30:717-44, viii. [Crossref]  [PubMed]
  10. Marais BJ, Gie RP, Schaaf HS, Starke JR, Hesseling AC, Donald PR, et al. A proposed radiological classification of childhood intra-thoracic tuberculosis. Pediatr Radiol. 2004;34:886-94. [Crossref]  [PubMed]
  11. Restrepo CS, Katre R, Mumbower A. Imaging Manifestations of Thoracic Tuberculosis. Radiol Clin North Am. 2016;54:453-73. [Crossref]  [PubMed]
  12. Bhalla AS, Goyal A, Guleria R, Gupta AK. Chest tuberculosis: Radiological review and imaging recommendations. Indian J Radiol Imaging. 2015;25:213-25. [Crossref]  [PubMed]  [PMC]
  13. Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ, Jr., Shroff GS, et al. Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management. Radiographics. 2017;37:52-72. [Crossref]  [PubMed]
  14. Van Dyck P, Vanhoenacker FM, Van den Brande P, De Schepper AM. Imaging of pulmonary tuberculosis. Eur Radiol. 2003;13:1771-85. [Crossref]  [PubMed]
  15. Curvo-Semedo L, Teixeira L, Caseiro-Alves F. Tuberculosis of the chest. Eur J Radiol. 2005;55:158-72. [Crossref]  [PubMed]
  16. Nel M, Franckling-Smith Z, Pillay T, Andronikou S, Zar HJ. Chest Imaging for Pulmonary TB-An Update. Pathogens. 2022;11. [Crossref]  [PubMed]  [PMC]
  17. Ruby LC, Heuvelings CC, Grobusch MP, Andronikou S, Bélard S. Transthoracic mediastinal ultrasound in childhood tuberculosis: A review. Paediatr Respir Rev. 2022;41:40-8. [Crossref]  [PubMed]
  18. Bosch-Marcet J, Serres-Créixams X, Zuasnabar-Cotro A, Codina-Puig X, Català-Puigbó M, et al. Comparison of ultrasound with plain radiography and CT for the detection of mediastinal lymphadenopathy in children with tuberculosis. Pediatr Radiol. 2004;34:895-900. [Crossref]  [PubMed]
  19. Bélard S, Andronikou S, Pillay T, Grobusch MP, Zar HJ. New imaging approaches for improving diagnosis of childhood tuberculosis. S Afr Med J. 2014;104:181-2. [Crossref]  [PubMed]
  20. Morello R, De Rose C, Ferrari V, Valentini P, Musolino AM, et al. Utility and Limits of Lung Ultrasound in Childhood Pulmonary Tuberculosis: Lessons from a Case Series and Literature Review. Journal of clinical medicine. 2022;11. [Crossref]  [PubMed]  [PMC]
  21. Naranje P, Bhalla AS, Sherwani P. Chest Tuberculosis in Children. Indian J Pediatr. 2019;86:448-58. [Crossref]  [PubMed]
  22. Tonne EO, Fosbøl M, Poulsen A, Nygaard U, Højgaard L, Borgwardt L. Imaging modalities for pulmonary tuberculosis in children: A systematic review. Eur J Radiol Open. 2023;10:100472. [Crossref]  [PubMed]  [PMC]
  23. Sodhi KS, Sharma M, Saxena AK, Mathew JL, Singh M, Khandelwal N. MRI in Thoracic Tuberculosis of Children. Indian J Pediatr. 2017;84:670-76. [Crossref]  [PubMed]
  24. Kapur S, Bhalla AS, Jana M. Pediatric Chest MRI: A Review. Indian J Pediatr. 2019;86:842-53. [Crossref]  [PubMed]
  25. Pillay T, Zar HJ, Venkatakrishna SSB, Andronikou S. Fast magnetic resonance imaging for diagnosing pulmonary tuberculosis in children: the sub-10-min unenhanced scan. Pediatr Radiol. 2023. [Crossref]  [PubMed]
  26. Kosterink JG. Positron emission tomography in the diagnosis and treatment management of tuberculosis. Curr Pharm Des. 2011;17:2875-80. [Crossref]  [PubMed]
  27. Kim IJ, Lee JS, Kim SJ, Kim YK, Jeong YJ, Jun S, et al. Double-phase 18F-FDG PET-CT for determination of pulmonary tuberculoma activity. Eur J Nucl Med Mol Imaging. 2008;35:808-14. [Crossref]  [PubMed]