ADVANCED TECHNOLOGIES IN ORAL AND MAXILLOFACIAL SURGERY

MaxillofacialSurgerydakapak

REGENERATIVE APPROACHES IN ORAL AND MAXILLOFACIAL SURGERY: BIOMATERIALBASED TECHNOLOGIES AND OPEN CHALLENGES

Hacer Eberliköse1 Seher Yaylacı2 Hakan Ceylan3

1Ankara Medipol University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara, Türkiye
2Lokman Hekim University, Faculty of Medicine, Department of Medical Biology, Ankara, Türkiye
3Mayo Clinic College of Medicine and Sciences, Department of Physiology and Biomedical Engineering, Mayo Clinic, 85254 Arizona, USA

Eberliköse H, Yaylacı S, Ceylan H. Regenerative Approaches in Oral and Maxillofacial Surgery: Biomaterial based Technologies and Open Challenges. Karasu HA, ed. Advanced Technologies in Oral and Maxillofacial Surgery. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.5362.

ABSTRACT

Regenerative dentistry and oralmaxillofacial surgery have experienced significant progress, especially in biomaterialbased approaches. These advancements encompass conventional tissue grafting and innovative methods, including stem cell therapy, growth factors, and bioengineered scaffolds. Natural biomaterials such as collagen, elastin, fibrin, and bone morphogenetic proteins (BMPs) exhibit promise in tissue repair and regeneration. Likewise, synthetic biomaterials such as polymers, ceramics, and metals have markedly enhanced bone integration, implant longevity, and soft tissue repair.

Stem cell research has played a pivotal role in regenerative therapies, with dental pulp stem cells (DP SCs), stem cells from human exfoliated deciduous teeth (SHED), and stem cells from the apical papilla (SCAP) showing promise for dental and craniofacial regeneration. The advent of induced pluripotent stem cells (iPSCs) has significantly transformed the field, facilitating patientspecific therapies. Simul taneously, advancements in bioengineering, including 3D printing and nanotechnologybased medica tion delivery systems, have improved the accuracy and efficacy of regenerative dentistry treatments.

Notwithstanding these breakthroughs, some hurdles endure, including ethical dilemmas associated with stem cell applications, exorbitant charges, and the intricacy of replicating natural tissue charac teristics. Furthermore, guaranteeing sustained treatment stability and broadening the accessibility of these medicines continue to pose considerable challenges. Future investigations seek to enhance bio materials, maximize regenerative methodologies, and include artificial intelligence for individualized treatment strategies. Through sustained interdisciplinary collaboration, regenerative dentistry is set to revolutionize patient care by providing minimally invasive and highly effective treatments for intricate dental and maxillofacial disorders.

Keywords: Regenerative medicine; Mesenchymal stem cells; Mandibular reconstruction; Printing; ThreeDimensional

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