RESPIRATORY PHISIOLOGY
Emine Aslanlar
Selçuk University, Faculty of Medicine, Department of Anesthesiology, Konya, Türkiye
Aslanlar E. Respiratory Phisiology In: Kazancı D, editor. Anesthesiology Fast Review. 1st ed. Ankara: Türkiye Klinikleri; 2025. p.3-8.
ABSTRACT
- One of the major complications of anesthesia is hypoxemia. Hypoxemia is caused by right-to-left shunt, ventilation-perfusion mismatch, and alveolar hypoventilation.
- Anesthesia increases respiratory workload by decreasing lung compliance.
- The V/Q (Ventilation/Perfusion) ratio, which shows the harmony between ventilation (V) and perfusion (Q), does not have the same value everywhere in the lung.
- Functional Residual Capacity (FRC) is influenced by patient position, with the highest FRC in the upright position and decreases in the supine, prone and head-down positions (greatest decrease).
- The rate of development of atelectasis in anesthetized patients is 90%. The rate of atelectasis after cardiac surgery and thoracic surgery is higher than other types of surgery.
Keywords: Anesthesia; Lung; Ventilation; Perfusion
×
Kaynak Göster
Referanslar
- Lieberman DA, Faulkner JA, Craig AB, Jr., Maxwell LC. Performance and histochemical composition of guinea pig and human diaphragm. J Appl Physiol. 1973;34(2):233-237. [Crossref] [PubMed]
- Bachofen M, Weibel ER. Basic pattern of tissue repair in human lungs following unspecific injury. Chest. 1974;65:Suppl:14S-19S. [Crossref] [PubMed]
- Fishman AP. Nonrespiratory functions of the lungs. Chest.1977;72(1):84-89. [Crossref] [PubMed]
- Hocking WG, Golde DW. The pulmonary-alveolar macrophage (first of two parts). N Engl J Med. 1979;301(11):580-587. [Crossref] [PubMed]
- Marshall R. The physical properties of the lungs in relation to the subdivisions of lung volume. Clin Sci. 1957;16(3):507-515. [PubMed]
- Fry DL, Hyatt RE. Pulmonary mechanics. A unified analysis of the relationship between pressure, volume and gasflow in the lungs of normal and diseased human subjects. Am J Med. 1960;29:672-689. [Crossref] [PubMed]
- Desai JP, Moustarah F. Pulmonary Compliance. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [PubMed]
- Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. Eur Respir J. 1999;13(1):197-205. [Crossref] [PubMed]
- Yamanaka MK, Sue DY. Comparison of arterial-end-tidal PCO2 difference and dead space/tidal volume ratio in respiratory failure. Chest. 1987;92(5):832-835. [Crossref] [PubMed]
- West JB, Dollery CT, Naimark A. Distribution of Blood Flow in Isolated Lung; Relation To Vascular And Alveolar Pressures. J Appl Physiol. 1964;19:713-724. [Crossref] [PubMed]
- Wagner PD, Laravuso RB, Uhl RR, West JB. Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100 per cent O2. J Clin Invest.1974;54(1):54-68. [Crossref] [PubMed] [PMC]
- Petersson J, Glenny RW. Gas exchange and ventilation-perfusion relationships in the lung. Eur Respir J. 2014;44(4):1023-1041. [Crossref] [PubMed]
- Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol (1985). 2005;98(1):390-403. [Crossref] [PubMed]
- Hallett S, Toro F, Ashurst JV. Physiology, Tidal Volume. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Pierce R. Spirometry: An Essential Clinical Measurement. Aust Fam Physician. 2005;34(7):535-539. [PubMed]
- David S, Sharma S. Vital Capacity. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Haddad M, Sharma S. Physiology, Lung. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Katz S, Arish N, Rokach A, Zaltzman Y, Marcus EL. The effect of body position on pulmonary function: a systematic review. BMC Pulm Med. 2018;18(1):159. [Crossref] [PubMed] [PMC]
- Bellemare F, Jeanneret A, Couture J. Sex differences in thoracic dimensions and configuration. Am J Respir Crit Care Med. 2003;168(3):305-312. [Crossref] [PubMed]
- Grott K, Chauhan S, Sanghavi DK, Dunlap JD. Atelectasis. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Hopkins E, Sharma S. Physiology, Functional Residual Capacity. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Lofrese JJ, Tupper C, Denault D, Lappin SL. Physiology, Residual Volume. In: StatPearls. Treasure Island (FL) ineligible companies. StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025. [Link]
- Wahba RW. Perioperative functional residual capacity. Can J Anaesth. 1991;38(3):384-400. [Crossref] [PubMed]
- Hedenstierna G, Edmark L. The effects of anesthesia and muscle paralysis on the respiratory system. Intensive Care Med. 2005;31(10):1327-1335. [Crossref] [PubMed]
- Don H. The mechanical properties of the respiratory system during anesthesia. Int Anesthesiol Clin. 1977;15(2):113-136. [Crossref] [PubMed]
- Gunnarsson L, Tokics L, Gustavsson H, Hedenstierna G. Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia. Br J Anaesth. 1991;66(4):423-432. [Crossref] [PubMed]
- Tenling A, Hachenberg T, Tydén H, Wegenius G, Hedenstierna G. Atelectasis and gas exchange after cardiac surgery. Anesthesiology. 1998;89(2):371-378. [Crossref] [PubMed]
- Fischer MO, Brotons F, Briant AR, et al. Postoperative Pulmonary Complications After Cardiac Surgery: The VENICE International Cohort Study. J Cardiothorac Vasc Anesth. 2022;36(8 Pt A):2344-2351. [Crossref] [PubMed]
- Hedenstierna G, Edmark L. Mechanisms of atelectasis in the perioperative period. Best Pract Res Clin Anaesthesiol. 2010;24(2):157-169. [Crossref] [PubMed]
- Lagier D, Zeng C, Fernandez-Bustamante A, Vidal Melo MF. Perioperative Pulmonary Atelectasis: Part II. Clinical Implications. Anesthesiology. 2022;136(1):206-236. [Crossref] [PubMed] [PMC]
- Östberg E, Thorisson A, Enlund M, Zetterström H, Hedenstierna G, Edmark L. Positive End-expiratory Pressure Alone Minimizes Atelectasis Formation in Nonabdominal Surgery: A Randomized Controlled Trial. Anesthesiology. 2018;128(6):1117-1124. [Crossref] [PubMed]
- Almarakbi WA, Fawzi HM, Alhashemi JA. Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patients. Br J Anaesth. 2009;102(6):862-868. [Crossref] [PubMed]
- Severgnini P, Selmo G, Lanza C, et al. Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function. Anesthesiology. 2013;118(6):1307-1321. [Crossref] [PubMed]