Salmonellosis in Laboratory Animals

veterinerbilichastaliklari10-3-24kapak

Serdar PAŞAa , Tahir ÖZALPa , Hasan ERDOĞANa
aAydın Adnan Menderes University Faculty of Veterinary Medicine, Department of Internal Medicine, Aydın, Türkiye

ABSTRACT
Salmonellosis poses a major health challenge globally, due to its prevalence in humans, domestic animals, and laboratory animals, leading to significant financial and health impacts. Over 2500 serotypes have been recognized, mainly within S. enterica subsp. enterica. While clinical laboratories categorize it into six serogroups for practical purposes, comprehensive serotyping is required for precise identification, aiding in the epidemiological understanding and management of infections. The review discusses the impact of salmonellosis on laboratory animals, which despite stringent management practices, remains a concern due to the zoonotic potential of the disease and the possibility of contaminating laboratory environments. Historical data reveals a shift in the prevalence of specific serovars in lab mice, emphasizing the dynamic nature of Salmonella infections. Molecular studies have identified numerous virulence factors, highlighting the pathogen’s complexity and the need for vigilant monitoring in research settings. The impact of Salmonella extends to various laboratory animals, each presenting specific challenges and necessitating tailored management practices to mitigate the risk of outbreaks and ensure the integrity of biomedical research. This review delineates the necessity for rigorous surveillance and hygiene protocols in laboratory settings to prevent salmonellosis, underscoring the economic and health ramifications of the disease, as well as the biological complexity of the Salmonella genus.

Keywords: Diseases; animals, laboratory; salmonella

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