Sarkopenia-Malnutration and Frailty in Geriatric Oncology

tibbi onkoloji ozel 13-4 kapak

Süleyman Emre KOÇYİĞİTa, Fatma Sena DOST GÜNAYa, Pınar SOYSALb

aDokuz Eylül Üniversitesi Tıp Fakültesi, Geriatri BD, Yaşlanan Beyin ve Demans Ünitesi, İzmir, TÜRKİYE
bBezmiâlem Vakıf Üniversitesi Tıp Fakültesi, Geriatri BD, İstanbul, TÜRKİYE

ABSTRACT
Malnutrition, sarcopenia and frailty, important geriatric syndromes, affect morbidity and mortality in older adults. Malignancy increases with age. It was shown that cancer might be associated with many geriatric syndromes. Malnutrition is important in elderlycancer patients. There are several factors that affect malnutrition in the elderly. Malignancies are one of these. Malnutrition is a predictor of the response to surgery and chemotherapy. Sarcopenia is also an important factor in the elderly. Lean muscle mass may be related to the toxicity of chemotherapy. Various types of chemotherapeutic agents cancers might increase toxicity in sarcopenia with older adults. Frailty ,another geriatric syndrome, is defined as decrease in the physiological reserve and increase in resistance to physical and psychological stresses. Many chronic diseases are managed according to the frailty status. The same is true for cancer patients in older adults. Therefore, comprehensive geriatric assessment should be an important part of geriatric oncology practice.
Keywords: Protein-energy malnutrition; sarcopenia; frailty

Referanslar

  1. Zhang X, Meng X, Chen Y, Leng SX, Zhang H. The Biology of Aging and Cancer: Frailty, Inflammation , and Immunity. Cancer J. 2017;23(4):201-205. [Crossref]
  2. Mohile SG, Fan L, Reeve E, Jean-Pierre P, Mustian K, Peppone L, et al. Association of cancer with geriatric syndromes in older Medicare beneficiaries. J Clin Oncol. 201110;29(11):1458-64. [Crossref]  [PubMed]  [PMC]
  3. Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;20;32(24):2595-603. [Crossref]  [PubMed]  [PMC]
  4. Cederholm T, Bosaeus I, Barazzoni R, Bauer J, Van Gossum A, Klek S, et al. Diagnostic criteria for malnutrition-an ESPEN consensus statement. Clin Nutr. 2015;34:335- 40. [Crossref]  [PubMed]
  5. Waterlow JC, Tomkins AM, Grantham-McGregor SM. Protein energy malnutrition Edward Arnold, London (1992)
  6. Pirlich M, Schütz T, Kemps M, Luhman N, Minko N, Lübke HJ, et al. Social risk factors for hospital malnutrition. Nutrition. 2005;21:295-300. [Crossref]  [PubMed]
  7. Gariballa SE, Sinclair AJ. Nutrition, ageing and ill health. Br J Nutr. 1998;80:7-23. [Crossref]  [PubMed]
  8. Cederholm T, Bosaeus I, Barazzoni R, Bauer J, Van Gossum A, Klek S, et al.Diagnostic criteria for malnutrition - an ESPEN consensus statement. Clin Nutr. 2015;34: 335-340. [Crossref]  [PubMed]
  9. Agarwal E, Miller M, Yaxley A, Isenring E. Malnutrition in the elderly: a narrative review. Maturitas. 2013;76(4):296-302. [Crossref]  [PubMed]
  10. Kondrup J, Allison SP, Elia M, Vellas B, Plauth M. Educational and clinical practice committee, European society of parenteral and enteral nutrition (ESPEN). ESPEN guidelines for nutrition screening 2002 Clin Nutr. 2003;22:415-421. [Crossref]  [PubMed]
  11. Kotler DP. Cachexia. Ann Intern Med. 2000; 133:622. [Crossref]  [PubMed]
  12. Hickson M. Malnutrition and ageing. Postgrad Med J. 2006; 82:2-8. [Crossref]  [PubMed]  [PMC]
  13. Isenring E, Elia M. Which screeninig method is appropriate for cancer patients at risk for malnutrition? Nutrition. 2015;31(4):594- 7. [Crossref]  [PubMed]
  14. Elia M, Van Bokhorst-de van der Schueren MA, Garvey J, Goedhart A, Lundholm K, Nitenberg G, et al. Enteral (oral or tube administration) nutritional support and eicosapentaenoic acid in patients with cancer: a systematic review. Int J Oncol. 2006;28:5- 23. [Crossref]  [PubMed]
  15. Brownie S. Why are elderly individuals at risk of nutritional deficiency? Int J Nurs Pract. 2006;12:110-8. [Crossref]  [PubMed]
  16. Evidence based practice guidelines for the nutritional management of malnutrition in adult patients across the continuum of care. Nutr Diet. 2009;66:S1-34. [Crossref]
  17. Head & neck guideline steering committee. Evidence based practice MClinical Oncological Society of Australia; 2011.
  18. Bozzetti F, Mariani L, Lo Vullo S, SCRINO Working Group, Amerio ML, Biffi R, et al. The nutritional risk in oncology: a study of 1,453 cancer outpatients. Support Care Cancer. 2012;20:1919-28. [Crossref]  [PubMed]  [PMC]
  19. Mariani L, Lo Vullo S, Bozzetti F, SCRINO Working Group. Weight loss in cancer patients: a plea for a better awareness of the issue. Support Care Cancer. 2012;20:301-9. [Crossref]  [PubMed]
  20. Martucci RB, Barbosa MV, D'Almeida CA, Rodrigues VD, Bergmann A, de Pinho NB, Thuler LC. undernutrition as independent predictor of early mortality in elderly cancer patients. Nutrition. 2017;34:65-70. [Crossref]  [PubMed]
  21. Caillet P, Laurent M, Bastuji-Garin S, Liuu E, Culine S, Lagrange JL, et al. Optimal management of elderly cancer patients: usefulness of the Comprehensive Geriatric Assessment. Clin Interv Aging. 2014;29;9:1645-60. [Crossref]  [PubMed]  [PMC]
  22. Prado CM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, et al. Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment.Clin Cancer Res. 2009;15;15(8):2920-6. [Crossref]  [PubMed]
  23. Antoun S, Baracos VE, Birdsell L, Escudier B, Sawyer MB. Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. Ann Oncol. 2010;21(8):1594-8. [Crossref]  [PubMed]
  24. Tufan A, Muratlı S, Tufan F. Malnutrisyon. Işık AT ve Çelik T, Geriatri Pratiğinde İlaç Tedavisi, 1.baskı, İstanbul, O'Tıp Kitabevi ve Yayıncılık. 2015;140-166.
  25. Alfonso J, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2018;0: 1-6.
  26. Tian S, Xu Y. Association of sarcopenic obesity with the risk of all-cause mortality: A metaanalysis of prospective cohort studies. Geriatr Gerontol Int . 2016; 16:155-66. [Crossref]  [PubMed]
  27. Rolland Y, Lauwers-Cances V, Cristini C, Abellan van Kan G, Janssen I, Morley JE, Vellas B.Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) Study. Am J Clin Nutr. 2009; 89:1895. [Crossref]  [PubMed]
  28. Williams GR, Deal AM, Muss HB, Weinberg MS, Sanoff HK, Nyrop KA, et al. Skeletal muscle measures and physical function in older adults with cancer: sarcopenia or myopenia? Oncotarget. 2017;16;8(20):33658-65. [Crossref]  [PubMed]  [PMC]
  29. Kim EY, Kim K, Kim YS, Ahn HK, Jeong YM, Kim JH, Choi WJ. Prevalance of and Factors Associated with Sarcopenia in Korean Cancer Survivors: Based on Data Obtained by the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011. Nutr Cancer. 2017;69(3):394-401. [Crossref]  [PubMed]
  30. Lee SJ, Park YJ, Cartmell KB. Sarcopenia in cancer survivors is associated with increased cardiovascular disease risk. Support Care Cancer.2018;26(7):2313-21. [Crossref]  [PubMed]
  31. Colloca G, Di Capua B, Bellieni A, Cesari M, Valentini V, Marzetti E, Calvani R. Muscoloskeletal aging, sarcopenia and cancer. J Geriatr Oncol. 2018 Dec 11. pii: S1879- 4068(18)30039-0.
  32. Zhou CJ, Zhang FM, Zhang FY, Yu Z, Chen XL, Shen X, et al. Sarcopenia: a new predictor of postoperative complications for elderly gastric cancer patientswho underwent radical gastrectomy. J Surg Res. 2017;1;211:137-146. [Crossref]  [PubMed]
  33. Yamamoto K, Nagatsuma Y, Fukuda Y, Hirao M, Nishikawa K, Miyamoto A, et al. Effectiveness of a preoperative exercise and nutritional support program for elderly sarcopenicpatients with gastric cancer. Gastric Cancer. 2017;20(5):913-8. [Crossref]  [PubMed]
  34. Nakashima Y, Saeki H, Nakanishi R, Sugiyama M, Kurashige J, Oki E, Maehara Y. Assessment of Sarcopenia as a Predictor of Poor Outcomes After Esophagectomy in Elderly ElderlyPatients With Esophageal Cancer. Ann Surg. 2018;267(6):1100-4. [Crossref]  [PubMed]
  35. Deng HY, Hou L, Zha P, Huang KL, Peng L. Sarcopenia is an independent unfavorable prognostic factor of non-small cell lung cancer aftersurgical resection: A comprehensive systematic review and meta-analysis. Eur J Surg Oncol. 2018; pii: S0748-7983(18)31446-X.
  36. Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, et al. Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non-small-cell lung cancer. BMC Cancer.2017;25;17(1): 571. [Crossref]  [PubMed]  [PMC]
  37. Vega MC, Laviano A, Pimentel GD. Sarcopenia and chemotherapy-mediated toxicity. Einstein (Sao Paulo). 2016;14(4):580-584. [Crossref]  [PubMed]  [PMC]
  38. Bozzetti F. Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotheapy. Ann Oncol. 2017;1;28(9):2107- 18. [Crossref]  [PubMed]
  39. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991. [Crossref]  [PubMed]
  40. Leng SX, Cappola AR, Andersen RE, Blackman MR, Koenig K, Blair M, et al. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin6, in the geriatric syndrome of frailty. Aging Clin Exp Res. 2004;16:153. [Crossref]  [PubMed]
  41. Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, et al. Inflammation and frailty in the elderly: A systematic review and metaanalysis. Ageing Res Rev. 2016;31:1-8. [Crossref]  [PubMed]
  42. Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16:601. [Crossref]  [PubMed]  [PMC]
  43. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56:M14. [Crossref]  [PubMed]
  44. Huisingh-Scheetz M, Walston J. How should older adults with cancer be evaluated for frailty? J Geriatr Oncol. 2017;8(1):8-15. [Crossref]  [PubMed]  [PMC]
  45. Hamaker ME, Jonker JM, de Rooij SE, Vos AG, Smorenburg CH, van Munster BC. Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review. Lancet Oncol. 2012;13(10):e437-44. [Crossref]  [PubMed]
  46. Kristjansson SR, Nesbakken A, Jordhoy MS, Skovlund E, Audisio RA, Johannessen HO, et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol. 2010;76:208-17. [Crossref]  [PubMed]
  47. Indrakusuma R, Dunker MS, Peetoom JJ, Schreurs WH. Evaluation of preoperative geriatric assessment of elderly patients with colorectal carcinoma. A retrospective study. Eur J Surg Oncol. 2015;41:21-7. [Crossref]  [PubMed]
  48. Rodin MB, Mohile SG. A practical approach to geriatric assessment in oncology. J Clin Oncol. 2007;25:1936-44. [Crossref]  [PubMed]
  49. Turner G, Clegg A. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age uK and Royal College of General Practitioners report. Age Ageing. 2014;43:744-7. [Crossref]  [PubMed]
  50. Soysal P, Isik AT, Carvalho AF, Fernandes BS, Solmi M, Schofield P, et al. Oxidative stress and frailty: A systematic review and synthesis of the best evidence. Maturitas. 2017;99:66-72. [Crossref]  [PubMed]