Selective IgA Deficiency and Selective IgM Deficiency

Türkan Zeynep FENDOĞLUa , Şadan SOYYİĞİTb
aAnkara Bilkent City Hospital, Clinic of Immunology and Allergy Diseases, Ankara, Türkiye
bAnkara Yıldırım Beyazıt University Faculty of Medicine, Ankara Bilkent City Hospital, Clinic of Immunology and Allergy Diseases, Ankara, Türkiye

Fendoğlu TZ, Soyyiğit Ş. Selective IgA deficiency and selective IgM deficiency. Çölkesen F, ed. Primary Immunodeficiency Diseases in Adults. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.33-7.

ABSTRACT
Selective Immunoglubulin A (IgA) deficiency (sIgAD) is the most common primary immunodeficiency that presents with decreased serum IgA. Autoimmune diseases and infections (especially respiratory and gastrointestinal tract infections) may accompany patients with IgA deficiency. In the diagnosis of IgA deficiency, reaching the diagnosis with clinical suspicion in the absence of direct signs or symptoms may require an initial intuitive approach. Although selective immunoglubulin M (IgM) deficiency (sIgMD) has been described in children with fulminant meningococcal septicemia, it has been a primary immunodeficiency that has been largely overlooked. It is thought to be more common than initially realized. Infections caused by intracellular bacteria, viruses and fungi most often accompany this disease. Immunoglobulin therapy may be helpful for patients with sIgMD presenting with recurrent infections and inadequate antibody response to pneumococcal and/or other.

Keywords: Selective IgA deficiency; selective IgM deficiency; immunoglobulin A deficiency; primary immunodeficiency diseases

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