Selective IgA Deficiency and Selective IgM Deficiency

immunoloji-17-1-2024

Türkan Zeynep FENDOĞLUa , Şadan SOYYİĞİTb
aAnkara Bilkent City Hospital, Clinic of Immunology and Allergy Diseases, Ankara, Türkiye
bAnkara Yıldırım Beyazıt University Faculty of Medicine, Ankara Bilkent City Hospital, Clinic of Immunology and Allergy Diseases, Ankara, Türkiye

Fendoğlu TZ, Soyyiğit Ş. Selective IgA deficiency and selective IgM deficiency. Çölkesen F, ed. Primary Immunodeficiency Diseases in Adults. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.33-7.

ABSTRACT
Selective Immunoglubulin A (IgA) deficiency (sIgAD) is the most common primary immunodeficiency that presents with decreased serum IgA. Autoimmune diseases and infections (especially respiratory and gastrointestinal tract infections) may accompany patients with IgA deficiency. In the diagnosis of IgA deficiency, reaching the diagnosis with clinical suspicion in the absence of direct signs or symptoms may require an initial intuitive approach. Although selective immunoglubulin M (IgM) deficiency (sIgMD) has been described in children with fulminant meningococcal septicemia, it has been a primary immunodeficiency that has been largely overlooked. It is thought to be more common than initially realized. Infections caused by intracellular bacteria, viruses and fungi most often accompany this disease. Immunoglobulin therapy may be helpful for patients with sIgMD presenting with recurrent infections and inadequate antibody response to pneumococcal and/or other.

Keywords: Selective IgA deficiency; selective IgM deficiency; immunoglobulin A deficiency; primary immunodeficiency diseases

Referanslar

  1. Rawla P, Killeen RB, Joseph N. IgA Deficiency. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
  2. Burks AW, Holgate ST, O'Heir RE, Broide DH, Bacharier LB, Hershey GKK, et al. Middleton's Allergy Principles and Practice 9th ed. In: Buckley RH, Orange JS. Primary Immunodeficiency Diseases; Elsevier Health Sciences; 2020. p. 1139-40.
  3. Spicket G. Oxford Handsbook of Clinical Immunology and Allergy. 4th ed. United Kingdom: Oxford University Press; 2020.p.18-20.
  4. Abolhassani H, Gharib B, Shahinpour S, Masoom SN, Havaei A, Mirminachi B, et al. Autoimmunity in patients with selective IgA deficiency. J Investig Allergol Clin Immunol. 2015;25(2):112-9.
  5. Odineal DD, Gershwin ME. The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency. Clin Rev Allergy Immunol. 2020;58(1):107-33. [Crossref]  [PubMed]
  6. Yazdani R, Azizi G, Abolhassani H, Aghamohammadi A. Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management. Scand J Immunol. 2017;85(1):3-12. [Crossref]  [PubMed]
  7. Ludvigsson JF, Neovius M, Ye W, Hammarström L. IgA deficiency and risk of cancer: a population-based matched cohort study. J Clin Immunol. 2015;35(2):182-8. [Crossref]  [PubMed]
  8. Erkoçoğlu M, Metin A, Kaya A, Özcan C, Akan A, Civelek E, et al. Allergic and autoimmune disorders in families with selective IgA deficiency. Turk J Med Sci. 2017;47(2):592-8. [Crossref]  [PubMed]
  9. Louis AG, Gupta S. Primary selective IgM deficiency: an ignored immunodeficiency. Clin Rev Allergy Immunol. 2014;46(2):104-11. [Crossref]  [PubMed]
  10. Ni J, Zhang J, Chen Q, Chen Y, Liu J. The epidemiology and clinical features of selective immunoglobulin M deficiency: A single-center study in China. J Clin Lab Anal. 2020;34(7):e23289. [Crossref]  [PubMed]  [PMC]
  11. Caka C, Cimen O, Kahyaoğlu P, Tezcan İ, Cagdas D. Selective IgM deficiency: Follow-up and outcome. Pediatr Allergy Immunol. 2021;32(6):1327-34. [Crossref]  [PubMed]
  12. Janssen LMA, Macken T, Creemers MCW, Pruijt JFM, Eijk JJJ, de Vries E. Truly selective primary IgM deficiency is probably very rare. Clin Exp Immunol. 2018;191(2):203-11. [Crossref]  [PubMed]  [PMC]
  13. Yel L, Ramanuja S, Gupta S. Clinical and immunological features in IgM deficiency. Int Arch Allergy Immunol. 2009;150(3):291-8. [Crossref]  [PubMed]