Skin Cancers

Assist. Prof. Dr. İpek Pınar ARAL

Ankara Bilkent City Hospital, Department of Radiation Oncology, Ankara, Türkiye Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Radiation Oncology, Ankara, Türkiye

ABSTRACT

Nutritional habits play an important role in etiology, prevention and treatment of many diseases such as can- cer. Nutritional science (NSF), the science that studies the relationship between nutrition and diseases, is be- coming increasingly important today. Micronutrients, a component of Nutritional Science (NSF), include trace elements and vitamins. This review summarizes the relationship between micronutrients and skin cancer, the most common cancer type worldwide.

Keywords: Micronutrients; Skin neoplasms; Minerals; Vitamins

Referanslar

  1. Rojas KD, Perez ME, Marchetti MA, Nichols AJ, Penedo FJ, Jaimes N. Skin cancer: Primary, secondary, and tertiary pre- vention. Part II. J Am Acad Dermatol. 2022;87(2):271-288. [Crossref]  [PubMed]
  2. Escudero-Góngora MM, Fernández-Peñas P. Nicotin- amide. New Indications in Dermatology. Actas Dermosi- filiogr. 2016;107(9):777-778. [Crossref]  [PubMed]
  3. Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consen- sus-based interdisciplinary guideline. Eur J Cancer. 2015;51: 1989-2007. [Crossref]  [PubMed]
  4. Frydrych A, Krośniak M, Jurowski K. The Role of Cho- sen Essential Elements (Zn, Cu, Se, Fe, Mn) in Food for Special Medical Purposes (FSMPs) Dedicated to On- cology Patients-Critical Review: State-of-the-Art. Nu- trients. 2023;15(4):1012. [Crossref]  [PubMed]
  5. Lahoda Brodska H, Klempir J, Zavora J, Kohout P. The Role of Micronutrients in Neurological Disorders. Nu- trients. 2023;15(19):4129. [Crossref]  [PubMed]
  6. Reichrath J, Saternus R, Vogt T. Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-mela- noma skin cancer, and beyond. Mol Cell Endocrinol. 2017; 453:96-102. [Crossref]  [PubMed]
  7. Mason RS, Reichrath J. Sunlight vitamin D and skin cancer. Anticancer Agents Med Chem. 2013;13(1):83-97. [Crossref]
  8. Holick M F, Binkley N C, Bischoff-Ferrari H A, Gordon C M, Hanley D A, Heaney R P. et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Me- tab. 2011;96(7):1911-1930. [Crossref]  [PubMed]
  9. Balcı C, Toktaş N. D Vitamini Sentezi, Metabolizmasi ve Sağ- lik Üzerine Etkileri. Gazi Sağlık Bilim Derg.2021;6(1):33-47. [Link]
  10. Holick MF.Vitamin D deficiency. N Engl J Med.2007; 357:266-281. [Crossref]  [PubMed]
  11. Field S, Newton-Bishop JA. Melanoma and vitamin D. Mol Oncol. 2011;5(2):197-214. [Crossref]  [PubMed]
  12. Ben-Shoshan M, Amir S, Dang DT, Dang LH, Weisman Y, Mabjeesh NJ. 1Alpha,25-dihydroxyvitamin D3 (calcitri- ol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. Mol Cancer Ther. 2007; 6(4): 1433-1439. [Crossref]  [PubMed]
  13. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE. 1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res. 2000; 87(3): 214-220. [Crossref]  [PubMed]
  14. Campbell MJ, Elstner E, Holden S, Uskokovic M, Koeffler HP. Inhibition of proliferation of prostate cancer cells by a 19-NOR-hexafluoride vitamin D3 analogue involves the induction of p21WAF1, p27KIP1 and E-cadherin. J Mol En- docrinol. 1997; 19(1): 15-27. [Crossref]  [PubMed]
  15. Lopes N, Carvalho J, Duraes C, Sousa B, Gomes M, Costa JL, et al. 1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation. Anticancer Res. 2012; 32(1): 249-257. [PubMed]
  16. Hsu JW, Yasmin-Karim S, King MR, Wojciechowski JC, Mickelsen D, Blair ML, et al. Suppression of prostate cancer cell rolling and adhesion to endothelium by 1alpha,25-di- hydroxyvitamin D3. Am J Pathol. 2011;178(2): 872-880. [Crossref]  [PubMed]
  17. Lin R. Crosstalk between Vitamin D Metabolism, VDR Signalling, and Innate Immunity. Biomed Res Int. 2016; 2016:1375858. [Crossref]  [PubMed]
  18. Seretis K, Bounas N, Sioka C. The Association of Vitamin D with Non-Melanoma Skin Cancer Risk: An Umbrella Re- view of Systematic Reviews and Meta-Analyses. Medicina (Kaunas). 2023;59(12):2130. [Crossref]  [PubMed]
  19. Reichrath J, Kamradt J, Zhu XH, Kong XF, Tilgen W, Hol- ick MF. Analysis of 1,25-dihydroxyvitamin D (3) receptors (VDR) in basal cell carcinomas. Am J Pathol. 1999; 155 (2): 583-589. [Crossref]  [PubMed]
  20. Mitschele T, Diesel B, Friedrich M, Meineke V, Maas RM, Gartner BC et al. Analysis of the vitamin D system in basal cell carcinomas (BCCs). Lab Invest. 2004: 84 (6); 693-702. [Crossref]  [PubMed]
  21. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015; 93 (5): 349-354. [Crossref]  [PubMed]
  22. Kostner K, Denzer N, Muller CS, Klein R, Tilgen W, Re- ichrath J. The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anti- cancer Res. 2009;29 (9): 3511-3536. [PubMed]
  23. Kostner K, Denzer N, Koreng M, Reichrath S, Graber S, Klein R, et al. Association of genetic variants of the vitamin D receptor (VDR) with cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC): a pilot study in a German population. Anticancer Res.2012; 32 (1): 327-333. [PubMed]
  24. Ramachandran S, Fryer AA, Lovatt T J, Smith AG, Lear JT, Jones PW, et al. Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of in- crease in numbers of basal cell carcinomas as a model sys- tem. Cancer Lett. 2003: 189 (2): 175-181. [Crossref]  [PubMed]
  25. Han J, Colditz GA, Hunter DJ. Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Carcinogen- esis. 2007; 28 (2): 390-397. [Crossref]  [PubMed]
  26. Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, et al. Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and in- duction of vitamin D receptor signaling and differentiation. Mol Cancer Ther. 2011;10(11):2179-2188. [Crossref]  [PubMed]
  27. Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Re- zaee F, Peppelenbosch MP. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol. 2006;4(8):e232. [Crossref]  [PubMed]
  28. Abdelwahab R, Huang R, Potla S, Bhalla S, AlQabandi Y, Nandula SA, et al. The Relationship between Vitamin D and Basal Cell Carcinoma: A Systematic Review. Cureus. 2022;14(9):e29496. [Crossref]  [PubMed]
  29. Caini S, Gnagnarella P, Stanganelli I, Bellerba F, Coco- rocchio E, Queirolo P, et al. Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Re- view and Meta-Analysis on Behalf of the Italian Melano- ma Intergroup. Cancers (Basel). 2021;13(19):4815. [Crossref]  [PubMed]
  30. Mahamat-Saleh Y, Aune D, Schlesinger S. 25-Hydroxyvi- tamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of pro- spective studies. Sci Rep. 2020;10(1):13151. [Crossref]  [PubMed]
  31. Colston K, Colston MJ, Feldman D. 1,25-dihydroxyvita- min D3 and malignant melanoma: The presence of recep- tors and inhibition of cell growth in culture. Endocrinolo- gy. 1981; 108(3): 1083-1086. [Crossref]  [PubMed]
  32. Brożyna AA, Hoffman RM, Slominski AT. Relevance of Vi- tamin D in Melanoma Development, Progression and Therapy. Anticancer Res. 2020 ;40(1):473-489. [Crossref]  [PubMed]
  33. Cattaruzza MS, Pisani D, Fidanza L, Gandini S, Marmo G, Narcisi A, et al. 25-hydroxyvitamin D serum levels and melanoma risk: A case-control study and evidence syn- thesis of clinical epidemiological studies. Eur J Cancer Prev. 2019;28(3):203-211. [Crossref]  [PubMed]
  34. Newton-Bishop JA, Beswick S, Randerson-Moor J, Chang YM, Affleck P, Elliott F, et al. Serum 25-hydroxyvitamin D3 levels are associated with Breslow thickness at presentation and survival from melanoma. J Clin Oncol. 2009: 27(32); 5439-5444. [Crossref]  [PubMed]
  35. Wyatt C, Lucas RM, Hurst C, Kimlin MG. Vitamin D de- ficiency at melanoma diagnosis is associated with high- er Breslow thickness. PLoS One. 2015: 10(5); e0126394. [Crossref]  [PubMed]
  36. Bade B, Zdebik A, Wagenpfeil S, Graber S, Geisel J, Vogt T, et al. Low serum 25-hydroxyvitamin D concentrations are associated with increased risk for melanoma and unfa- vourable prognosis. PLoS One.2014: 9(12); e112863, [Crossref]  [PubMed]
  37. Lim A, Shayan R, Varigos G: High serum vitamin D level correlates with better prognostic indicators in primary mela- noma: A pilot study. Australas J Dermatol. 2018; 59(3): 182-187. [Crossref]  [PubMed]
  38. Saiag P, Aegerter P, Vitoux D, Lebbé C, Wolkenstein P, Dup- in N, et al. Prognostic Value of 25-hydroxyvitamin D3 Levels at Diagnosis and During Follow-up in Melanoma Patients. J Natl Cancer Inst. 2015;107(12):djv264. [Crossref]  [PubMed]
  39. Nürnberg B, Gräber S, Gärtner B, Geisel J, Pföhler C, Schadendorf D, et al. Reduced serum 25-hydroxyvita- min D levels in stage IV melanoma patients. Anticancer Res. 2009;29(9):3669-3674. [PubMed]
  40. Verdin E. NAD+ in aging, metabolism, and neurodegener- ation. Science. 2015;350:1208-1213. [Crossref]  [PubMed]
  41. Gibson BA, Kraus WL. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol. 2012; 13:411-424. [Crossref]  [PubMed]
  42. Escudero-Góngora MM, Fernández-Peñas P. Nicotin-amide: New Indications in Dermatology. Actas Dermosi- filiogr. 2016;107(9):777-778. [Crossref]  [PubMed]
  43. Hyeraci M, Papanikolau ES, Grimaldi M, Ricci F, Pallotta S, Monetta R, et al. Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer. Biomolecules. 2023 Jul 2;13(7):1067. [Crossref]  [PubMed]
  44. Jamison A, Malhotra R. Nicotinamide and Nonmelanoma Skin Cancers. Ophthalmic Plast Reconstr Surg. 2022;38(3):304-305. [Crossref]  [PubMed]
  45. Hunt SV, Jamison A, Malhotra R. Oral nicotinamide for non-melanoma skin cancers: A review. Eye (Lond). 2023;37(5):823-829. [Crossref]  [PubMed]
  46. Sailo BL, Banik K, Padmavathi G, Javadi M, Bordoloi D, Kunnumakkara AB. Tocotrienols: The promising an- alogues of vitamin E for cancer therapeutics. Pharmacol Res. 2018;130:259-272. [Crossref]  [PubMed]
  47. Marzagalli M, Moretti RM, Messi E, Marelli MM, Fon- tana F, Anastasia A, et al. Targeting melanoma stem cells with the Vitamin E derivative -tocotrienol. Sci Rep. 2018;8(1):587. [Crossref]  [PubMed]
  48. McNaughton SA, Marks GC, Green AC. Role of dietary factors in the development of basal cell cancer and squa- mous cell cancer of the skin. Cancer Epidemiol Biomarkers Prev. 2005;14(7):1596-1607. [Crossref]  [PubMed]
  49. Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. [Crossref]  [PubMed]
  50. Pernice C, Murri D, Valli R, Crocetta FM, Iori M, Asti M, et al. Complete response of cutaneous SCC to topical treat- ment with ascorbic acid solution: A case report. Clin Case Rep. 2021;9:1060-1065. [Crossref]  [PubMed]
  51. Holló P, Jókai H, Hársing J, Soós G, Kárpáti S, NémethK. Topically applied ascorbic acid solution for the treat- ment of basal cell carcinoma (BCC). J Am Acad Derma- tol. 2016;75(1):212-213. [Crossref]  [PubMed]
  52. Capponi PC, Murri D, Pernice C. Topical L-Ascorbic Acid Formulation for a Better Management of Non-Melanoma Skin Cancer: Perspective for Treatment Strategies. Phar- maceutics. 202;13(8):1201. [Crossref]  [PubMed]
  53. Jackson MJ. Physiology of zinc: General aspects. Mills CF, editor. Zinc in Human Biology. 1st edition. Spring- er; 1989. p. 1-14. [Crossref]
  54. Rostan EF, DeBuys HV, Madey DL, Pinnell SR. Evidence supporting zinc as an important antioxidant for skin. Int J Dermatol. 2002;41(9):606-611. [Crossref]  [PubMed]
  55. Thompson KG, Kim N. Dietary supplements in derma- tology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. J Am Acad Derma- tol. 2021;84(4):1042-1050. [Crossref]  [PubMed]
  56. Razaghi A, Poorebrahim M, Sarhan D, Björnstedt M. Sele- nium stimulates the antitumour immunity: Insights to future research. Eur J Cancer. 2021;155:256-267. [Crossref]  [PubMed]
  57. Rogoża-Janiszewska E, Malińska K, Baszuk P, Marcin- iak W, Derkacz R, Lener M, et al. Serum Selenium Lev- el and 10-Year Survival after Melanoma. Biomedicines. 2021;9(8):991. [Crossref]  [PubMed]
  58. Pence BC, Delver E, Dunn DM. Effects of dietary selenium on UVB-induced skin carcinogenesis and epidermal antioxi- dant status. J Invest Dermatol. 1994;102(5):759-761. [Crossref]  [PubMed]
  59. Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF Jr, et al. Nutritional Prevention of Cancer Study Group. Selenium supplementation and second- ary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst. 2003;95(19):1477-1481. [Crossref]  [PubMed]
  60. Cassidy PB, Fain HD, Cassidy JP Jr, Tran SM, Moos PJ, Boucher KM, et al. Selenium for the prevention of cutaneous melanoma. Nutrients. 2013;5(3):725-749. [Crossref]  [PubMed]
  61. Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, et al. Selenium for preventing cancer. Co- chrane Database Syst Rev. 2018;1(1):CD005195. [PubMed]
  62. Takahashi N, Saito D, Hasegawa S, Yamasaki M, Imai M. Vitamin A in health care: Suppression of growth and induc- tion of differentiation in cancer cells by vitamin A and its derivatives and their mechanisms of action. Pharmacol Ther. 2022;230:107942. [Crossref]  [PubMed]
  63. Doldo E, Costanza G, Agostinelli S, Tarquini C, Ferlosio A, Arcuri G, et al. Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins. Biomed Res Int. 2015; 2015:624627. [Crossref]  [PubMed]
  64. Wei Q, Matanoski GM, Farmer ER, Strickland P, GrossmanL. Vitamin supplementation and reduced risk of basal cell carcinoma. J Clin Epidemiol. 1994;47:829-836. [Crossref]  [PubMed]
  65. Davies TW, Treasure FP, Welch AA, Day NE. Diet and basal cell skin cancer: results from the EPIC-Norfolk cohort. Br J Dermatol. 2002;146: 1017-1022. [Crossref]  [PubMed]
  66. Hunter DJ, Colditz GA, Stampfer MJ, Rosner B, Willett WC, Speizer FE. Diet and risk of basal cell carcinoma of the skin in a prospective cohort of women. Ann Epide- miol. 1992;2(3):231-239. [Crossref]  [PubMed]
  67. van Dam RM, Huang Z, Giovannucci E, Rimm EB, Hunter DJ, Colditz GA, et al. Diet and basal cell carcino- ma of the skin in a prospective cohort of men. Am J Clin Nutr. 2000;71(1):135-141. [Crossref]  [PubMed]
  68. Breslow RA, Alberg AJ, Helzlsouer KJ, Bush TL, Norkus EP, Morris JS, et al. Serological precursors of cancer: malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, beta- carotene, lycopene, al- pha-tocopherol, and selenium. Cancer Epidemiol Biomark- ers Prev. 1995;4(8):837-842. [PubMed]
  69. Moon TE, Levine N, Cartmel B, Bangert JL, Rodney S, Dong Q, et al. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev. 1997;6(11):949-956. [PubMed]