Stevens-Johnson Sendromu ve Toksik Epidermal Nekroliz

Ferda BİLGİRa
aİzmir Kâtip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, İmmünoloji ve Alerji Hastalıkları Kliniği, İzmir, TÜRKİYE

Bilgir F. Stevens-Johnson sendromu ve toksik epidermal nekroliz. Çildağ S, editör. İmmünolojik ve Alerjik Deri Hastalıkları. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.57-62.

ÖZET
Stevens-Johnson Sendromu (SJS) ve Toksik Epidermal Nekroliz (TEN) yaşamı tehdit eden mukokutanöz hastalıklardır. SJS/TEN ilaçlara bağlı geç tip hipersensitivite reaksiyonlarıdır. Antikonvülzanlar, sülfonamidler, antibiyotikler, nonsteroid antienflamatuarlar ve kortikosteroidler suçlu ajanlar olarak raporlanmıştır. Belli ilaçlara bağlı hipersensitivite reaksiyonlarında risk artışı spesifik HLA antijenleriyle ilişkilidir. Akut febril hastalık ve deri lezyonlarıyla karekterize prodromal fazı epidermal ayrılma izler. İnsidansı çok düşüktür (0.4-1.2/milyon/yıl). SJS/TEN mortalitesi %5-30 aralığındadır. Kısa ve uzun dönem morbiditeler oldukça yaygındır. Tedavi multidisiplinerdir ve özel bir üniteye nakil, destekleyici bakım, medikal tedavi ve psikolojik desteği içerir.SJS/TEN tedavisinde en çok kullanılanlar kortikosteroidler, immünglobulinler ve siklosporin A’dır.

Anahtar Kelimeler: Stevens-Johnson sendromu; toksik epidermal nekrolizis; ilaç reaksiyonu

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